scholarly journals Serum Withdrawal-Induced Apoptosis in ZrchI Prion Protein (PrP) Gene-Deficient Neuronal Cell Line Is Suppressed by PrP, Independent of Doppel

2007 ◽  
Vol 51 (4) ◽  
pp. 457-466 ◽  
Author(s):  
Takuya Nishimura ◽  
Akikazu Sakudo ◽  
Yoriko Hashiyama ◽  
Akiko Yachi ◽  
Keiichi Saeki ◽  
...  
Keyword(s):  
Cell Line ◽  
Prion Protein ◽  
Neuronal Cell ◽  
Neuronal Cell Line ◽  
Serum Withdrawal ◽  
Induced Apoptosis ◽  
Prp Gene

Protective effects of Orostachys japonicus A. Berger (Crassulaceae) on H2O2-induced apoptosis in GT1-1 mouse hypothalamic neuronal cell line

2000 ◽  
Vol 69 (1) ◽  
pp. 73-78 ◽  
Author(s):  
Yoosik Yoon ◽  
Kyung-Seok Kim ◽  
Seong-Gil Hong ◽  
Bong-Joo Kang ◽  
Mi-Young Lee ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuronal Cell ◽  
Protective Effects ◽  
Neuronal Cell Line ◽  
Induced Apoptosis

scholarly journals Cellular Prion Protein and Caveolin-1 Interaction in a Neuronal Cell Line Precedes Fyn/Erk 1/2 Signal Transduction

2006 ◽  
Vol 2006 ◽  
pp. 1-13 ◽  
Author(s):  
Mattia Toni ◽  
Enzo Spisni ◽  
Cristiana Griffoni ◽  
Spartaco Santi ◽  
Massimo Riccio ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Line ◽  
Prion Protein ◽  
Neuronal Cell ◽  
Cellular Prion Protein ◽  
Glutathione S Transferase ◽  
Neuronal Cell Line ◽  
Caveolin 1 ◽  
Fyn Kinase

It has been reported that cellular prion protein (PrPc) is enriched in caveolae or caveolae-like domains with caveolin-1 (Cav-1) participating to signal transduction events by Fyn kinase recruitment. By using the Glutathione-S-transferase (GST)-fusion proteins assay, we observed that PrPc strongly interacts in vitro with Cav-1. Thus, we ascertained the PrPc caveolar localization in a hypothalamic neuronal cell line (GN11), by confocal microscopy analysis, flotation on density gradient, and coimmunoprecipitation experiments. Following the anti-PrPc antibody-mediated stimulation of live GN11 cells, we observed that PrPc clustered on plasma membrane domains rich in Cav-1 in which Fyn kinase converged to be activated. After these events, a signaling cascade through p42/44 MAP kinase (Erk 1/2) was triggered, suggesting that following translocations from rafts to caveolae or caveolae-like domains PrPc could interact with Cav-1 and induce signal transduction events.

Neurotoxic Prion Protein (PrP) Fragment 106-126 Requires the N-terminal Half of the Hydrophobic Region of PrP in the PrP-Deficient Neuronal Cell Line

2007 ◽  
Vol 14 (1) ◽  
pp. 1-6
Author(s):  
Akikazu Sakudo ◽  
Izuru Nakamura ◽  
Deug-Chan Lee ◽  
Keiichi Saeki ◽  
Kazuyoshi Ikuta ◽  
...  
Keyword(s):  
Cell Line ◽  
Prion Protein ◽  
Neuronal Cell ◽  
Hydrophobic Region ◽  
Neuronal Cell Line

Zinc protects against arsenic-induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity

BioMetals ◽  
2004 ◽  
Vol 17 (6) ◽  
pp. 707-713 ◽  
Author(s):  
Austin Graham Milton ◽  
Peter David Zalewski ◽  
Ranjit Nihal Ratnaike
Keyword(s):  
Cell Line ◽  
Neuronal Cell ◽  
Caspase Activity ◽  
Neuronal Cell Line ◽  
Induced Apoptosis

Changes in cellular prion protein expression, processing and localisation during differentiation of the neuronal cell line CAD 5

2019 ◽  
Vol 112 (1) ◽  
pp. 1-21 ◽  
Author(s):  
Zuzana Fremuntova ◽  
Tibor Mosko ◽  
Jakub Soukup ◽  
Johanka Kucerova ◽  
Marie Kostelanska ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cell Line ◽  
Prion Protein ◽  
Neuronal Cell ◽  
Cellular Prion Protein ◽  
Neuronal Cell Line ◽  
Expression Processing

Involvement of TNF-α in glutamate-induced apoptosis in a differentiated neuronal cell line

2006 ◽  
Vol 1122 (1) ◽  
pp. 201-208 ◽  
Author(s):  
Jiro Kogo ◽  
Yuko Takeba ◽  
Toshio Kumai ◽  
Yasushi Kitaoka ◽  
Naoki Matsumoto ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuronal Cell ◽  
Neuronal Cell Line ◽  
Tnf Α ◽  
Induced Apoptosis

Impairment of superoxide dismutase activation by N-terminally truncated prion protein (PrP) in PrP-deficient neuronal cell line

2003 ◽  
Vol 308 (3) ◽  
pp. 660-667 ◽  
Author(s):  
Akikazu Sakudo ◽  
Deug-chan Lee ◽  
Keiichi Saeki ◽  
Yuko Nakamura ◽  
Keiichi Inoue ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Cell Line ◽  
Prion Protein ◽  
Neuronal Cell ◽  
Neuronal Cell Line

Cellular prion protein suppresses the apoptosis in a neuronal cell line established from type-1 prion protein gene-deficient mice

Prions ◽  
2006 ◽  
pp. 203-203
Author(s):  
Keiichi Saeki ◽  
Takuya Nishimura ◽  
Akikazu Sakudo ◽  
Yoshitsugu Matsumoto ◽  
Takashi Onodera
Keyword(s):  
Cell Line ◽  
Prion Protein ◽  
Protein Gene ◽  
Neuronal Cell ◽  
Cellular Prion Protein ◽  
Prion Protein Gene ◽  
Neuronal Cell Line ◽  
Deficient Mice
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