Formation of 8-hydroxy-2'-deoxyguanosine in the DNA of cultured human keratinocytes by clinically used doses of narrowband and broadband ultraviolet B and psoralen plus ultraviolet A

2006 ◽  
Vol 97 (2) ◽  
pp. 99-105 ◽  
Author(s):  
Hiroshi Orimo ◽  
Yoshiki Tokura ◽  
Ryosuke Hino ◽  
Hiroshi Kasai
Keyword(s):  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Ultraviolet A

scholarly journals UVB protective effects of Sargassum horneri through the regulation of Nrf2 mediated antioxidant mechanism

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eui Jeong Han ◽  
Seo-Young Kim ◽  
Hee-Jin Han ◽  
Hyun-Soo Kim ◽  
Kil-Nam Kim ◽  
...  
Keyword(s):  
Skin Barrier ◽  
Human Keratinocytes ◽  
Underlying Mechanism ◽  
Ultraviolet B ◽  
Sargassum Horneri ◽  
Cellular Damage ◽  
Protective Effects ◽  
Skin Damage ◽  
Antioxidant Mechanism ◽  
Induced Apoptosis

AbstractThe present study aimed to evaluate the protective effect of a methanol extract of Sargassum horneri (SHM), which contains 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (HTT) and apo-9′-fucoxanthinone, against ultraviolet B (UVB)-induced cellular damage in human keratinocytes and its underlying mechanism. SHM significantly improved cell viability of UVB-exposed human keratinocytes by reducing the generation of intracellular reactive oxygen species (ROS). Moreover, SHM inhibited UVB exposure-induced apoptosis by reducing the formation of apoptotic bodies and the populations of the sub-G1 hypodiploid cells and the early apoptotic cells by modulating the expression of the anti- and pro-apoptotic molecules, Bcl-2 and Bax, respectively. Furthermore, SHM inhibited NF-κB p65 activation by inducing the activation of Nrf2/HO-1 signaling. The cytoprotective and antiapoptotic activities of SHM are abolished by the inhibition of HO-1 signaling. In further study, SHM restored the skin dryness and skin barrier disruption in UVB-exposed human keratinocytes. Based to these results, our study suggests that SHM protects the cells against UVB-induced cellular damages through the Nrf2/HO-1/NF-κB p65 signaling pathway and may be potentially useful for the prevention of UVB-induced skin damage.

A novel apoptosis inducer, apoptosis signal regulating kinase (ASK1), is involved in ultraviolet B-induced apoptosis of cultured human keratinocytes

1998 ◽  
Vol 16 ◽  
pp. S69 ◽  
Author(s):  
Koji Sayama ◽  
Hidenori Ichijo ◽  
Kenshi Yamasaki ◽  
Yashushi Hanakawa ◽  
Yuji Shirakata ◽  
...  
Keyword(s):  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Apoptosis Inducer ◽  
Induced Apoptosis

scholarly journals Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
Frances P. Noonan ◽  
M. Raza Zaidi ◽  
Agnieszka Wolnicka-Glubisz ◽  
Miriam R. Anver ◽  
Jesse Bahn ◽  
...  
Keyword(s):  
Ultraviolet B ◽  
Melanin Pigment ◽  
Ultraviolet A ◽  
Ultraviolet B Radiation

scholarly journals Ultraviolet A-induced Modulation of Bcl-XLby p38 MAPK in Human Keratinocytes

2004 ◽  
Vol 279 (41) ◽  
pp. 42658-42668 ◽  
Author(s):  
Michael A. Bachelor ◽  
G. Timothy Bowden
Keyword(s):  
P38 Mapk ◽  
Human Keratinocytes ◽  
Ultraviolet A
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