Review article: thrombocytopenia in chronic liver disease and pharmacologic treatment options

2006 ◽  
Vol 23 (8) ◽  
pp. 1055-1065 ◽  
Author(s):  
E. G. GIANNINI
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Treatment Options ◽  
Review Article ◽  
Chronic Liver ◽  
Pharmacologic Treatment

scholarly journals Recent advances in understanding and managing hepatic encephalopathy in chronic liver disease

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 312
Author(s):  
Annarein J. C. Kerbert ◽  
Rajiv Jalan
Keyword(s):  
Liver Disease ◽  
Hepatic Encephalopathy ◽  
Chronic Liver Disease ◽  
Treatment Options ◽  
Review Article ◽  
Routine Clinical Practice ◽  
Chronic Liver ◽  
Recent Advances ◽  
Key Drivers

Hepatic encephalopathy (HE) is a common, severe complication of advanced chronic liver disease (CLD) and has a devastating impact on the patient’s quality of life and prognosis. The neurotoxin ammonia and the presence of systemic and neurological inflammation are considered the key drivers of this neuropsychiatric syndrome. Treatment options available in routine clinical practice are limited, and the development of novel therapies is hampered owing to the complexity and heterogeneity of HE. This review article aims to outline the current understanding of the pathomechanisms of HE and the recent advances in the identification and development of novel therapeutic targets.

Treatment Options for Thrombocytopenia in Patients With Chronic Liver Disease Undergoing a Scheduled Procedure

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sammy Saab ◽  
David Bernstein ◽  
Tarek Hassanein ◽  
Marcelo Kugelmas ◽  
Paul Kwo
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Treatment Options ◽  
Chronic Liver

Liver cirrhosis: Child-Pugh grading of cases seen in Nigeria

2005 ◽  
Vol 35 (3) ◽  
pp. 169-171 ◽  
Author(s):  
D A Ndububa ◽  
O S Ojo ◽  
A O Aladegbaiye ◽  
R A Adebayo ◽  
V A Adetiloye ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Treatment Options ◽  
Diagnostic Procedures ◽  
Chronic Liver ◽  
Surgical Interventions ◽  
B Virus ◽  
Time Of Presentation

Child-Pugh grading is an important determinant of treatment options, surgical interventions and prognosis in chronic liver disease. Sixty-four liver cirrhosis patients (49 men, 15 women) seen at Ile-Ife, Nigeria were graded according to the Child-Pugh parameters. Only one (1.6%) was in Class A, while 21 (32.8%) and 42 (65.6%) were in Classes B and C, respectively. Thirty-four either had coagulopathy or were already in encephalopathy at the time of presentation. Hepatitis B virus-associated disease was present in 64% of the patients. Most Nigerian cirrhosis patients present with very advanced disease; they are thus poor-risk candidates for diagnostic procedures and surgery. Efforts should be intensified at making the diagnosis at a much earlier stage and universal immunization with the hepatitis B vaccine should be commenced to reduce the incidence of HBV-related chronic liver disease in Nigeria.

scholarly journals Management of Pruritus in Chronic Liver Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Angeline Bhalerao ◽  
Gurdeep S. Mannu
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Treatment Options ◽  
Database Systems ◽  
Chronic Liver ◽  
Cholestatic Liver Disease ◽  
Common Symptom ◽  
Medical Treatments ◽  
Mesh Terms ◽  
Opioid Receptor Antagonists

Background.There continues to be uncertainty on the ideal treatment of pruritus in chronic liver disease. The aim of this study was to gather the latest information on the evidence-based management of pruritus in chronic liver disease.Methodology.A literature search for pruritus in chronic liver disease was conducted using Pubmed and Embase database systems using the MeSH terms “pruritus,” “chronic liver disease,” “cholestatic liver disease,” and “treatment.”Results.The current understanding of the pathophysiology of pruritus is described in addition to detailing research into contemporary treatment options of the condition. These medical treatments range from bile salts, rifampicin, and opioid receptor antagonists to antihistamines.Conclusion.The burden of pruritus in liver disease patients persists and, although it is a common symptom, it can be difficult to manage. In recent years there has been greater study into the etiology and treatment of the condition. Nonetheless, pruritus remains poorly understood and many patients continue to suffer, reiterating the need for further research to improve our understanding of the etiology and treatment for the condition.

scholarly journals Review article: blood platelet number and function in chronic liver disease and cirrhosis

2008 ◽  
Vol 27 (11) ◽  
pp. 1017-1029 ◽  
Author(s):  
P. WITTERS ◽  
K. FRESON ◽  
C. VERSLYPE ◽  
K. PEERLINCK ◽  
M. HOYLAERTS ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Blood Platelet ◽  
Review Article ◽  
Chronic Liver ◽  
Platelet Number ◽  
And Function

Liver Disease in Pregnancy

2015 ◽  
Author(s):  
Matthew S Chang ◽  
Anna E. Rutherford
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Viral Hepatitis ◽  
Chronic Liver Disease ◽  
Hyperemesis Gravidarum ◽  
Treatment Options ◽  
Chronic Liver ◽  
Biliary Disease ◽  
Elevated Liver Enzymes ◽  
In Pregnancy

Liver disease in pregnancy can be unique to pregnancy or coincidental to pregnancy, or pregnancy can occur in women with chronic liver disease, cirrhosis, or portal hypertension. The gestational age of the pregnancy can help determine the diagnosis. Liver disease occurring during pregnancy has the potential to be life threatening to mother and fetus, and any elevation in liver tests should be investigated. Disorders unique to pregnancy include hyperemesis gravidarum; intrahepatic cholestasis of pregnancy; preeclampsia/eclampsia; hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome; and acute fatty liver of pregnancy. Liver diseases coincidental to pregnancy include acute viral hepatitis, gallstones/biliary disease, and thrombosis such as Budd-Chiari syndrome/hepatic vein thrombosis. Pregnant women may have chronic liver disease or cirrhosis from all of the same etiologies as nonpregnant women, most commonly chronic viral hepatitis. Treatment options may differ during pregnancy because of the potential risks to the fetus. Women who have cirrhosis or portal hypertension or who are post liver transplantation should be managed in conjunction with a hepatologist.  This review contains 4 figures, 6 tables and 40 references Key words: acute liver failure, delivery, trimester  

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