Organ transplant recipients and skin cancer: assessment of risk factors with focus on sun exposure

Background: Organ transplant recipients (OTRs) are at an increased risk of developing a de novo malignant neoplasm compared to the general population. The primary contributor to skin cancer in all patients is sun exposure. Objective: In this study, we aim to ascertain both OTR skin cancer awareness and photoprotection practices. Methods: A questionnaire-based study of Saskatchewan transplant recipients. Results: Nearly all respondents were aware that sun exposure is the best-known cause of skin cancer and that as an OTR, they are at increased risk of skin cancer (99.3% and 90.5%, respectively). Approximately half of respondents reported wearing a hat regularly, sun avoidance between 10 am and 3 pm, or wearing sunscreen regularly (53.7%, 33.1%, and 47.9%, respectively). Conclusion: Many OTRs are not engaging in photoprotection. Further intervention, which may include access to a dermatologist, is necessary to ensure ORTs do not experience undue morbidity and mortality secondary to skin cancer.

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Faculty Opinions recommendation of Incidence of and risk factors for skin cancer in organ transplant recipients in the united states.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727219497.793539332 ◽

2017 ◽

Author(s):

David Leffell

Keyword(s):

United States ◽

Risk Factors ◽

Skin Cancer ◽

Organ Transplant ◽

The United States ◽

Transplant Recipients ◽

Organ Transplant Recipients

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Skin Cancer Development in Solid Organ Transplant Recipients in Switzerland (Swiss Transplant Cohort Study)

Dermatology ◽

10.1159/000510685 ◽

2020 ◽

pp. 1-11

Author(s):

Nadja Angela Stenz ◽

Susanne Stampf ◽

Andreas W. Arnold ◽

Antonio Cozzio ◽

Michael Dickenmann ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Skin Cancer ◽

Cell Carcinoma ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Organ Transplant Recipients ◽

Solid Organ Transplant Recipients

Importance: Skin cancer, in particular squamous cell carcinoma, is the most frequent malignancy among solid organ transplant recipients with a higher incidence compared to the general population. Objective: To determine the skin cancer incidence in organ transplant recipients in Switzerland and to assess the impact of immunosuppressants and other risk factors. Design: Prospective cohort study of solid organ transplant recipients in Switzerland enrolled in the Swiss Transplant Cohort Study from 2008 to 2013. Participants: 2,192 solid organ transplant recipients. Materials and Methods: Occurrence of first and subsequent squamous cell carcinoma, basal cell carcinoma, melanoma and other skin cancers after transplantation extracted from the Swiss Transplant Cohort Study database and validated by medical record review. Incidence rates were calculated for skin cancer overall and subgroups. The effect of risk factors on the occurrence of first skin cancer and recurrent skin cancer was calculated by the Cox proportional hazard model. Results: In 2,192 organ transplant recipients, 136 (6.2%) developed 335 cases of skin cancer during a median follow-up of 32.4 months, with squamous cell carcinoma as the most frequent one. 79.4% of skin cancer patients were male. Risk factors for first and recurrent skin cancer were age at transplantation, male sex, skin cancer before transplantation and previous transplantation. For a first skin cancer, the number of immunosuppressive drugs was a risk factor as well. Conclusions and Relevance: Skin cancer following solid organ transplantation in Switzerland is greatly increased with risk factors: age at transplantation, male sex, skin cancer before transplantation, previous transplantation and number of immunosuppressive drugs.

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