scholarly journals Genome-wide linkage of obstructive sleep apnoea and high-density lipoprotein cholesterol in a Filipino family: bivariate linkage analysis of obstructive sleep apnoea

2010 ◽  
Vol 19 (2) ◽  
pp. 349-357 ◽  
Author(s):  
BRONWYN L. RELF ◽  
EMMA K. LARKIN ◽  
CARINA DE TORRES ◽  
LOUISE A. BAUR ◽  
JOHN CHRISTODOULOU ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
High Density Lipoprotein ◽  
Obstructive Sleep Apnoea ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Sleep Apnoea ◽  
Lipoprotein Cholesterol ◽  
Genome Wide ◽  
Obstructive Sleep ◽  
Bivariate Linkage Analysis

Obstructive sleep apnoea/hypopnea influences high-density lipoprotein cholesterol in the elderly

2009 ◽  
Vol 10 (8) ◽  
pp. 882-886 ◽  
Author(s):  
Frédéric Roche ◽  
Emilia Sforza ◽  
Vincent Pichot ◽  
Delphine Maudoux ◽  
Arnaultd Garcin ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Obstructive Sleep Apnoea ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
The Elderly ◽  
Sleep Apnoea ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Obstructive Sleep

scholarly journals A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

2012 ◽  
Vol 15 (6) ◽  
pp. 691-699 ◽  
Author(s):  
Ida Surakka ◽  
John B. Whitfield ◽  
Markus Perola ◽  
Peter M. Visscher ◽  
Grant W. Montgomery ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Monozygotic Twin ◽  
High Density ◽  
Genome Wide Association ◽  
Lipoprotein Cholesterol ◽  
Genome Wide ◽  
A Genome

Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene–environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10−8). We followed up the association in further genotyped monozygotic twins (N = 1,261), which showed a moderate association for the variant (P = 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P = 4.03 × 10−8).

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