Hepatitis C core protein impairs insulin downstream signalling and regulatory role of IGFBP-1 expression

2011 ◽  
Vol 19 (1) ◽  
pp. 65-71 ◽  
Author(s):  
M. Alberstein ◽  
T. Zornitzki ◽  
Y. Zick ◽  
H. Knobler
Keyword(s):  
Hepatitis C ◽  
Core Protein ◽  
Regulatory Role

scholarly journals Differential Effects on the Hepatitis C Virus (HCV) Internal Ribosome Entry Site by Vitamin B12 and the HCV Core Protein

2004 ◽  
Vol 78 (21) ◽  
pp. 12075-12081 ◽  
Author(s):  
Dongsheng Li ◽  
William B. Lott ◽  
John Martyn ◽  
Gholamreza Haqshenas ◽  
Eric J. Gowans
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosome Entry Site ◽  
Core Protein ◽  
Vitamin B ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Hcv Core Protein ◽  
Hcv Ires

ABSTRACT To investigate the role of the hepatitis C virus internal ribosome entry site (HCV IRES) domain IV in translation initiation and regulation, two chimeric IRES elements were constructed to contain the reciprocal domain IV in the otherwise HCV and classical swine fever virus IRES elements. This permitted an examination of the role of domain IV in the control of HCV translation. A specific inhibitor of the HCV IRES, vitamin B12, was shown to inhibit translation directed by all IRES elements which contained domain IV from the HCV and the GB virus B IRES elements, whereas the HCV core protein could only suppress translation from the wild-type HCV IRES. Thus, the mechanisms of translation inhibition by vitamin B12 and the core protein differ, and they target different regions of the IRES.

scholarly journals IL-10 plays a central regulatory role in the cytokines induced by hepatitis C virus core protein and polyinosinic acid:polycytodylic acid

2016 ◽  
Vol 38 ◽  
pp. 284-290 ◽  
Author(s):  
Xiaoli Pang ◽  
Zhaoxia Wang ◽  
Naicui Zhai ◽  
Qianqian Zhang ◽  
Hongxiao Song ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Regulatory Role ◽  
Virus Core

Role of Core Protein-Induced Oxidative Stress in the Pathogenesis of Hepatitis C

2003 ◽  
pp. 8-18
Author(s):  
Steven A. Weinman ◽  
Michiari Okuda ◽  
Kui Li ◽  
Lori A. Showalter ◽  
Kazuhiro Otani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepatitis C ◽  
Core Protein

scholarly journals Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction

2009 ◽  
Vol 17 (11) ◽  
pp. 784-793 ◽  
Author(s):  
T. Wang ◽  
R. V. Campbell ◽  
M. K. Yi ◽  
S. M. Lemon ◽  
S. A. Weinman
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mitochondrial Dysfunction ◽  
Core Protein ◽  
Virus Core

scholarly journals Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2

2008 ◽  
Vol 15 (5) ◽  
pp. 346-356 ◽  
Author(s):  
A. J. Pérez-Berná ◽  
A. S. Veiga ◽  
M. A. R. B. Castanho ◽  
J. Villalaín
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Binding ◽  
Lipid Membranes ◽  
Core Protein ◽  
Virus Core

Co-delivery of GM-CSF gene enhances the immune responses of hepatitis C viral core protein-expressing DNA vaccine: Role of dendritic cells

2002 ◽  
Vol 66 (3) ◽  
pp. 320-328 ◽  
Author(s):  
Pu Ou-Yang ◽  
Lih-Hwa Hwang ◽  
Mi-Hua Tao ◽  
Bor-Luen Chiang ◽  
Ding-Shinn Chen
Keyword(s):  
Dendritic Cells ◽  
Hepatitis C ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Core Protein ◽  
Viral Core ◽  
Gm Csf ◽  
Viral Core Protein

Profiles of HCV core protein and viremia in chronic Hepatitis C: possible protective role of core antigen in liver damage

2005 ◽  
Vol 76 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Alessandro Carabaich ◽  
Mariagrazia Ruvoletto ◽  
Elisabetta Bernardinello ◽  
Natascia Tono ◽  
Luisa Cavalletto ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Core Protein ◽  
Protective Role ◽  
Core Antigen ◽  
Hcv Core Protein

Distinct functional role of Hepatitis C virus core protein on NF-κB regulation is linked to genomic variation

2002 ◽  
Vol 87 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Ratna B Ray ◽  
Robert Steele ◽  
Arnab Basu ◽  
Keith Meyer ◽  
Mainak Majumder ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Functional Role ◽  
Core Protein ◽  
Genomic Variation ◽  
Virus Core
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