Background:
Thiosemicarbazone, 1,2,3-triazole and their derivatives received great pharmaceutical importance
due to their prominent biological activities. In the present study, the molecular hybrid thiosemicarbazone-1,2,3-triazoles derivatives were synthesized and screened for their antimicrobial activities.
Methods:
A series of thiosemicarbazone clubbed with 1,2,3-triazole derivatives were synthesized via click chemistry approach in good yields. The structures of synthesized compounds were assigned by their spectral data. The in vitro antimicrobial activity was performed by the agar well diffusion method. A molecular docking study was performed to identify the
possible mode of action of synthesized derivatives.
Results:
The compounds 5d, 5h, 5i and 5k have exhibited excellent antimicrobial activities against both antibacterial and
antifungal pathogens. The active thiosemicarbazone-1,2,3-triazole derivatives have shown excellent binding affinity towards
DNA gyrase.
Conclusion:
The molecular hybrid thiosemicarbazone-1,2,3-triazole derivatives were synthesized. The newly synthesized
compounds were evaluated for their antimicrobial activities. Few of the thiosemicarbazone-1,2,3-triazoles derivatives have
exhibited good antimicrobial activities. They have been shown excellent binding affinity towards DNA gyrase.