Differential gene expression in human brain pericytes induced by amyloid-β protein

2004 ◽  
Vol 30 (3) ◽  
pp. 279-291 ◽  
Author(s):  
A. A. M. Rensink ◽  
I. Otte-Höller ◽  
H. J. ten Donkelaar ◽  
R. M. W. De Waal ◽  
B. Kremer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Brain ◽  
Differential Gene Expression ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Brain Pericytes ◽  
Differential Gene

scholarly journals Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices

2012 ◽  
Vol 287 (10) ◽  
pp. 7436-7445 ◽  
Author(s):  
Adriano Sebollela ◽  
Leo Freitas-Correa ◽  
Fabio F. Oliveira ◽  
Andrea C. Paula-Lima ◽  
Leonardo M. Saraiva ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Brain ◽  
Differential Gene Expression ◽  
Brain Slices ◽  
Amyloid Β ◽  
Adult Human Brain ◽  
Adult Human ◽  
Differential Gene

scholarly journals Rapid Degeneration of Cultured Human Brain Pericytes by Amyloid β Protein

2002 ◽  
Vol 68 (3) ◽  
pp. 1135-1141 ◽  
Author(s):  
Marcel M. Verbeek ◽  
Robert M. W. De Waal ◽  
Janine J. Schipper ◽  
William E. Van Nostrand
Keyword(s):  
Human Brain ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Brain Pericytes

scholarly journals Vascular Genomics of the Human Brain

2002 ◽  
Vol 22 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Eric V. Shusta ◽  
Ruben J. Boado ◽  
Gary W. Mathern ◽  
William M. Pardridge
Keyword(s):  
Gene Expression ◽  
Human Brain ◽  
Differential Gene Expression ◽  
Molecular Transport ◽  
Brain Diseases ◽  
Microvascular Endothelium ◽  
Whole Brain ◽  
Differential Gene ◽  
Brain Microvasculature ◽  
The Brain

The microvasculature of the human brain plays an important role in the development and maintenance of the central nervous system and in the pathogenesis of brain diseases, and is the site of differential gene expression within the brain. However, human brain microvascular-specific genes may not be detected in whole-brain gene microarray because the volume of the brain microvascular endothelium is relatively small (0.1%) compared with the whole brain. Therefore, the differential gene expression within the human brain microvasculature was evaluated using suppression subtractive hybridization with RNA isolated from human brain microvessels. Gene identification was restricted to the first 71 clones that were differentially expressed at the brain microvasculature. Twenty of these were genes encoding proteins with known function that were involved in angiogenesis, neurogenesis, molecular transport, and maintenance of endothelial tight junctions or the cytoskeleton. Eighteen genes coding for proteins of an unknown function were identified, including five genes containing satellite DNA sequences. The results provide the initial outline of the genomics of the human brain microvasculature, and have implications for the identification of both targets for brain-specific drug transport and changes in microvascular gene expression in brain diseases.

scholarly journals Effect of Apolipoprotein E Allele ε4 on the Initial Phase of Amyloid β-Protein Accumulation in the Human Brain

2000 ◽  
Vol 157 (6) ◽  
pp. 2093-2099 ◽  
Author(s):  
Maho Morishima-Kawashima ◽  
Noriko Oshima ◽  
Hiromitsu Ogata ◽  
Haruyasu Yamaguchi ◽  
Masahiro Yoshimura ◽  
...  
Keyword(s):  
Human Brain ◽  
Apolipoprotein E ◽  
Initial Phase ◽  
Amyloid Β ◽  
Protein Accumulation ◽  
Amyloid Β Protein ◽  
Β Protein

Amyloid β Protein and Its 3-kDa Fragment Are Present in the Axoplasm Fraction of the White Matter in Human Brain

1996 ◽  
Vol 223 (1) ◽  
pp. 165-169 ◽  
Author(s):  
Takahiko Tokuda ◽  
Fuyuki Kametani ◽  
Kikuko Tanaka ◽  
Naruhiko Sahara ◽  
Shuichi Ikeda ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein
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