Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes

Background: We performed the present study to better elucidate the correlations of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms with the risk of congenital heart diseases (CHD). Methods: Eligible articles were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations of MTHFR and MTRR gene polymorphisms with CHD. Results: A total of 47 eligible studies were finally included in our meta-analysis. Our overall analyses suggested that MTRR rs1801394, MTRR rs1532268, MTHFR rs1801131 and MTHFR rs1801133 polymorphisms were all significantly associated with the risk of CHD in certain genetic models. Further subgroup analyses according to ethnicity of study participants demonstrated that the MTRR rs1801394 polymorphism was significantly correlated with the risk of CHD only in Asians, whereas MTRR rs1532268, MTHFR rs1801133 and MTHFR rs1801131 polymorphisms were significantly correlated with the risk of CHD in both Asians and Caucasians. Conclusions: Our findings indicated that MTRR rs1532268, MTHFR rs1801131 and MTHFR rs1801133 polymorphisms may affect the risk of CHD in Asians and Caucasians, while the MTRR rs1801394 polymorphism may only affect in risk of CHD in Asians.

Download Full-text

Impact of Methionine Synthase Gene and Methylenetetrahydrofolate Reductase Gene Polymorphisms on the Risk of Sudden Sensorineural Hearing Loss

Audiology and Neurotology ◽

10.1159/000093957 ◽

2006 ◽

Vol 11 (5) ◽

pp. 287-293 ◽

Cited By ~ 18

Author(s):

Menachem Gross ◽

Gideon Friedman ◽

Ron Eliashar ◽

Nira Koren-Morag ◽

Neta Goldschmidt ◽

...

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Gene Polymorphisms ◽

Methylenetetrahydrofolate Reductase ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Methionine Synthase ◽

Reductase Gene ◽

Methylenetetrahydrofolate Reductase Gene

Download Full-text

Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism

Genes & Nutrition ◽

10.1007/s12263-013-0358-2 ◽

2013 ◽

Vol 8 (6) ◽

pp. 571-580 ◽

Cited By ~ 15

Author(s):

Vikki Ho ◽

Thomas E. Massey ◽

Will D. King

Keyword(s):

Carbon Metabolism ◽

Gene Polymorphisms ◽

Methylenetetrahydrofolate Reductase ◽

Methionine Synthase ◽

Reductase Gene ◽

One Carbon Metabolism ◽

Methylenetetrahydrofolate Reductase Gene

Download Full-text

The role of homocysteine and methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase polymorphisms in the development of cardiovascular diseases and hypertension

Orvosi Hetilap ◽

10.1556/oh.2012.29326 ◽

2012 ◽

Vol 153 (12) ◽

pp. 445-453 ◽

Cited By ~ 4

Author(s):

Krisztina Marosi ◽

Annamária Ágota ◽

Veronika Végh ◽

József Gábor Joó ◽

Zoltán Langmár ◽

...

Keyword(s):

Cardiovascular Diseases ◽

Methylenetetrahydrofolate Reductase ◽

Developed Countries ◽

Methionine Synthase ◽

Gene Variants ◽

Mthfr Polymorphisms ◽

Methionine Synthase Reductase ◽

Reductase Gene ◽

The Developed Countries

Cardiovascular diseases (CVDs) are the leading causes of death in the developed countries. Elevated homocysteine level is as an independent risk factor of CVDs. The C677T and A1298C variants of methylenetetrahydrofolate reductase gene (MTHFR) have been shown to influence folate and homocysteine metabolisms. However, the relationship between MTHFR polymorphisms and hyperhomocysteinemia has not been well established yet. The gene variants were also reported to be associated with CVDs. In addition, the C677T polymorphisms may play a role in the development of hypertension. Recent research evidence has suggested that MTHFR variants might be independently linked to CVDs and hypertension, because of the involvement of the MTHFR enzyme product (5-methyl-tetrahydrofolate /5-MTHF) in the regulation of endothelial functions. Further research is required to investigate the association between gene polymorphisms of folate-metabolizing enzymes and CVDs, and to identify the possible role of the relevant gene variants in the molecular pathogenesis of hyperhomocysteinemia. Orv. Hetil., 2012, 153, 445–453.

Download Full-text