scholarly journals The roles of MTRR and MTHFR gene polymorphisms in congenital heart diseases: a meta-analysis

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Aiping Xu ◽  
Weiping Wang ◽  
Xiaolei Jiang
Keyword(s):  
Gene Polymorphisms ◽  
Congenital Heart ◽  
Methylenetetrahydrofolate Reductase ◽  
Heart Diseases ◽  
Meta Analysis ◽  
Mthfr Gene ◽  
Methionine Synthase ◽  
Congenital Heart Diseases ◽  
Methionine Synthase Reductase ◽  
Study Participants

Background: We performed the present study to better elucidate the correlations of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms with the risk of congenital heart diseases (CHD). Methods: Eligible articles were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations of MTHFR and MTRR gene polymorphisms with CHD. Results: A total of 47 eligible studies were finally included in our meta-analysis. Our overall analyses suggested that MTRR rs1801394, MTRR rs1532268, MTHFR rs1801131 and MTHFR rs1801133 polymorphisms were all significantly associated with the risk of CHD in certain genetic models. Further subgroup analyses according to ethnicity of study participants demonstrated that the MTRR rs1801394 polymorphism was significantly correlated with the risk of CHD only in Asians, whereas MTRR rs1532268, MTHFR rs1801133 and MTHFR rs1801131 polymorphisms were significantly correlated with the risk of CHD in both Asians and Caucasians. Conclusions: Our findings indicated that MTRR rs1532268, MTHFR rs1801131 and MTHFR rs1801133 polymorphisms may affect the risk of CHD in Asians and Caucasians, while the MTRR rs1801394 polymorphism may only affect in risk of CHD in Asians.

Correlation between Methylenetetrahydrofolate Reductase Polymorphisms and Hepatocellular Carcinoma: A Meta-Analysis

2019 ◽  
Vol 74 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Hailong Su ◽  
Guo Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Polymorphisms ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Random Effect ◽  
Recessive Model ◽  
Mthfr Gene ◽  
Systematic Research ◽  
The Relationship ◽  
Random Effect Models

Background: The correlation between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and hepatocellular carcinoma (HCC) remains controversial. Objectives: We performed this study to better assess the relationship between MTHFR gene polymorphisms and the likelihood of HCC. Methods: A systematic research of PubMed, Medline, and Embase was performed to retrieve relevant articles. ORs and 95% CIs were calculated. Results: A total of 15 studies with 8,378 participants were analyzed. In overall analyses, a significant association with the likelihood of HCC was detected for the rs1801131 polymorphism with fixed-effect models (FEMs) in recessive comparison (p = 0.002, OR 0.62, 95% CI 0.43–0.82). However, no positive results were detected for the rs1801133 polymorphism in any comparison. Further subgroup analyses revealed that the rs1801131 polymorphism was significantly associated with the likelihood of HCC in Asians with both FEMs (recessive model: p < 0.0001, OR 0.42, 95% CI 0.29–0.62; allele model: p = 0.004, OR 1.20, 95% CI 1.06–1.35) and random-effect models (recessive model: p = 0.002, OR 0.47, 95% CI 0.29–0.75). Nevertheless, we failed to detect any significant correlation between the rs1801133 polymorphism and HCC. Conclusions: Our findings indicated that the rs1801131 polymorphism may serve as a genetic biomarker of HCC in Asians.

scholarly journals Effect of MTHFR A1298C and MTRR A66G genetic mutations on homocysteine levels in the Chinese population: a systematic review and meta-analysis

2017 ◽  
Vol 5 (4) ◽  
pp. 220-229 ◽  
Author(s):  
Jiancheng Wang ◽  
Nengtai Ouyang ◽  
Long Qu ◽  
Tengfei Lin ◽  
Xianglin Zhang ◽  
...  
Keyword(s):  
Chinese Population ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Random Effect ◽  
Mthfr Gene ◽  
Folate Intake ◽  
Folic Acid Fortification ◽  
Mthfr A1298c ◽  
Methionine Synthase Reductase ◽  
Mtrr A66g

AbstractBackground and ObjectivesThe Chinese population typically has inadequate folate intake and no mandatory folic acid fortification. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the two key regulatory enzymes in the folate/homocysteine (Hcy) metabolism. Hcy has been implicated in the pathogenesis of cardiovascular disease. We conducted a meta-analysis to assess whether the MTHFR gene A1298C and the MTRR gene A66G polymorphisms affect Hcy levels in the Chinese population.MethodsThis analysis included 13 studies with Hcy levels reported as one of the study measurements. Summary estimates of weighted mean differences and 95% confidence intervals (CIs) were obtained using random-effect models.ResultsOverall, there were no significant differences in Hcy concentrations between participants with the MTHFR 1298 CC (12 trials,n= 129), AA (n= 2166; β, −0.51 μmol/L; 95%CI: −2.14, 1.11;P= 0.53), or AC genotype (n= 958; β, 0.55 μmol/L; 95%CI: −0.72, 1.82;P= 0.40). Consistently, compared to those with the MTRR 66 GG genotype (6 trials,n= 156), similar Hcy concentrations were found in participants with the AA (n= 832; β, −0.43 μmol/L; 95%CI: −1.04, 0.17;P= 0.16) or AG (n=743; β, −0.57 μmol/L; 95%CI: −1.46, 0.31;P= 0.21) genotype. Similar results were observed for the dominant and recessive models.ConclusionsNeither the MTHFR A1298C polymorphism nor the MTRR A66G polymorphism affects Hcy levels in the Chinese population.

Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases

2005 ◽  
Vol 84 (12) ◽  
pp. 1134-1140 ◽  
Author(s):  
Chien-Nan Lee ◽  
Yi-Ning Su ◽  
Wen-Fang Cheng ◽  
Ming-Tai Lin ◽  
Jou-Kou Wang ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Methylenetetrahydrofolate Reductase ◽  
Heart Diseases ◽  
Congenital Heart Diseases
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