Three-dimensional epidermis-like growth of human mesenchymal stem cells on dermal equivalents: contribution to tissue organization by adaptation of myofibroblastic phenotype and function

2008 ◽  
Vol 76 (2) ◽  
pp. 156-167 ◽  
Author(s):  
Rebekka K.M. Schneider ◽  
Sabine Neuss ◽  
Rebekah Stainforth ◽  
Nadja Laddach ◽  
Manfred Bovi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Tissue Organization ◽  
And Function ◽  
Dermal Equivalents

scholarly journals Three-dimensional carbon nanotube scaffolds for long-term maintenance and expansion of human mesenchymal stem cells

2017 ◽  
Vol 105 (7) ◽  
pp. 1927-1939 ◽  
Author(s):  
Gaurav Lalwani ◽  
Michael D'agati ◽  
Anu Gopalan ◽  
Sunny C. Patel ◽  
Yahfi Talukdar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Carbon Nanotube ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Term Maintenance

scholarly journals Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells

Nanoscale ◽  
2013 ◽  
Vol 5 (10) ◽  
pp. 4171 ◽  
Author(s):  
Spencer W. Crowder ◽  
Dhiraj Prasai ◽  
Rutwik Rath ◽  
Daniel A. Balikov ◽  
Hojae Bae ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Graphene Foams

Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells

Blood ◽  
2005 ◽  
Vol 105 (10) ◽  
pp. 4120-4126 ◽  
Author(s):  
Xiao-Xia Jiang ◽  
Yi Zhang ◽  
Bing Liu ◽  
Shuang-Xi Zhang ◽  
Ying Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dendritic Cells ◽  
Human Mesenchymal Stem Cells ◽  
Interleukin 4 ◽  
Human Mscs ◽  
Gm Csf ◽  
Macrophage Colony ◽  
And Function

AbstractMesenchymal stem cells (MSCs), in addition to their multilineage differentiation, have a direct immunosuppressive effect on T-cell proliferation in vitro. However, it is unclear whether they also modulate the immune system by acting on the very first step. In this investigation, we addressed the effects of human MSCs on the differentiation, maturation, and function of dendritic cells (DCs) derived from CD14+ monocytes in vitro. Upon induction with granulocyte-macrophage colony-stimulating factor (GM-CSF) plus interleukin-4 (IL-4), MSC coculture could strongly inhibit the initial differentiation of monocytes to DCs, but this effect is reversible. In particular, such suppression could be recapitulated with no intercellular contact at a higher MSC/monocyte ratio (1:10). Furthermore, mature DCs treated with MSCs were significantly reduced in the expression of CD83, suggesting their skew to immature status. Meanwhile, decreased expression of presentation molecules (HLA-DR and CD1a) and costimulatory molecules (CD80 and CD86) and down-regulated IL-12 secretion were also observed. In consistence, the allostimulatory ability of MSC-treated mature DCs on allogeneic T cells was impaired. In conclusion, our data suggested for the first time that human MSCs could suppress monocyte differentiation into DCs, the most potent antigen-presenting cells (APCs), thus indicating the versatile regulation of MSCs on the ultimate specific immune response.

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