Increased risk of nontuberculous mycobacterial infection in asthmatic patients using long-term inhaled corticosteroid therapy

Respirology ◽  
2011 ◽  
Vol 17 (1) ◽  
pp. 185-190 ◽  
Author(s):  
MASAYUKI HOJO ◽  
MOTOYASU IIKURA ◽  
SATOSHI HIRANO ◽  
HARUHITO SUGIYAMA ◽  
NOBUYUKI KOBAYASHI ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Mycobacterial Infection ◽  
Inhaled Corticosteroid ◽  
Asthmatic Patients ◽  
Increased Risk ◽  
Nontuberculous Mycobacterial Infection

Mortality and Prognostic Factors of Nontuberculous Mycobacterial Infection in Korea: A Population-based Comparative Study

2020 ◽  
Author(s):  
Hyewon Lee ◽  
Woojae Myung ◽  
Eun-Mi Lee ◽  
Hyekyeong Kim ◽  
Byung Woo Jhun
Keyword(s):  
General Population ◽  
Multivariable Analysis ◽  
Mycobacterial Infection ◽  
Population Based ◽  
Cumulative Survival ◽  
Survival Probabilities ◽  
International Classification Of Disease ◽  
Nontuberculous Mycobacterial Infection ◽  
Korean National Health Insurance

Abstract Background Population-based studies on the mortality burden of nontuberculous mycobacteria (NTM) infection are lacking. We compared the long-term mortality of NTM-infected patients with tuberculosis (TB)-patients and the general population, and investigated mortality-associated factors. Methods We analyzed nationwide-data from the Korean National Health Insurance and Korea-Statistical Office between 2002 and 2017. NTM infection was identified using the International Classification of Disease, Tenth Revision code, with one-to-one matching to TB patients and general population controls. Results A total of 530 401 individuals were analyzed, including 183 267 with NTM infections; 166 666 with TB; and 180 468 controls. The overall 6-, 10-, and 14-year cumulative survival probabilities in the NTM group were 86.3%, 80.8%, and 77.1%, respectively, which were significantly lower than those of the TB or control groups (log-rank P < .0001). In cases of NTM and TB coinfection, the overall 6-, 10-, and 14-year cumulative survival probabilities were 75.1%, 65.4%, and 57.0%, respectively. Multivariable analysis indicated that old age, male gender, province, and various respiratory or nonrespiratory comorbidities were significantly associated with mortality of NTM infection. The use of a macrolide (more than 1 year) negatively correlated with mortality of NTM infection (adjusted hazard ratio [aHR] 0.61, 95% confidence interval [CI] .53–.71), regardless of azithromycin (aHR 0.60, 95% CI .43–.85) or clarithromycin use (aHR 0.63, 95% CI .53–.75). Conclusions NTM-infected patients had poor prognosis when compared to TB patients or the general population, especially for NTM and TB coinfection. NTM mortality was associated with certain demographic characteristics, but long-term use of macrolides may provide survival benefits.

Bone ultrasonometric features and growth hormone secretion in asthmatic patients during chronic inhaled corticosteroid therapy

Bone ◽  
2006 ◽  
Vol 38 (1) ◽  
pp. 119-124 ◽  
Author(s):  
Mario Malerba ◽  
Simonetta Bossoni ◽  
Alessandro Radaeli ◽  
Erica Mori ◽  
Giuseppe Romanelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Corticosteroid Therapy ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Inhaled Corticosteroid ◽  
Asthmatic Patients

Salmeterol Powder Provides Significantly Better Benefit Than Montelukast in Asthmatic Patients Receiving Concomitant Inhaled Corticosteroid Therapy

CHEST Journal ◽  
2001 ◽  
Vol 120 (2) ◽  
pp. 423-430 ◽  
Author(s):  
James E. Fish ◽  
Elliot Israel ◽  
John J. Murray ◽  
Amanda Emmett ◽  
Rebecca Boone ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Inhaled Corticosteroid ◽  
Asthmatic Patients

Osteonecrosis 15 years after femoral neck fracture and long-term low-dose inhaled corticosteroid therapy

2004 ◽  
Vol 71 (3) ◽  
pp. 237-239 ◽  
Author(s):  
Kai Kisielinski ◽  
Christopher Niedhart ◽  
Ulrich Schneider ◽  
Fritz-Uwe Niethard
Keyword(s):  
Femoral Neck ◽  
Femoral Neck Fracture ◽  
Corticosteroid Therapy ◽  
Low Dose ◽  
Inhaled Corticosteroid ◽  
Neck Fracture

scholarly journals AB0742 PREVALENCE AND RISK FACTORS OF OSTEOPOROSIS IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1400.1-1400
Author(s):  
H. Bettaieb ◽  
H. Ferjani ◽  
K. Maatallah ◽  
H. Boussaa ◽  
D. Kaffel ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Disease Activity ◽  
Corticosteroid Therapy ◽  
Disease Activity Score ◽  
Disease Duration ◽  
Activity Score ◽  
Diagnosis Delay ◽  
Targeted Interventions ◽  
Increased Risk

Background:Childhood rheumatic diseases are associated with reduced Bone mass and increased risk of fractures (1). Several factors may interact to determine osteoporosis other than direct bone detrimental effects of the disease or its treatment.Objectives:In this work, we aimed to investigate the prevalence of bone loss in patients with JIA and to determine the relative factors associated with osteoporosis during this chronic disease.Methods:A retrospective monocentric study was carried out on JIA patients (ILAR criteria).Dual-energy x-ray absorptiometry (DEXA) was used to determine bone status. Disease activity was evaluated by JADAS10 (Juvenile Arthritis Disease Activity Score) in poly and oligoarticular subtypes and by BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) in arthritis related enthesitis form. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were noted. The data were analyzed using the SPSS statistical package. A p value < 0.05 was considered significant.Results:The sample included 40 JIA (25 male and 15 female) with a mean age at disease onset of 11.3 ± 3.6 years. The median disease duration was 90 months [7-408].The median JIA diagnosis delay was 8 months [1-108]. The JIA subgroups were in decreasing order of frequency: Enthesitis-related Arthritis (n=27), Polyarticular RF- (n=4), Polyarticular RF+ (n=1), Oligoarticular (n=4), Systemic (n=2), Psoriatic Arthritis (n=1) and Undifferentiated (n=1). Median ESR and CRP were 29 mm/hour [2-98] and 14.5 mg/l [0-70] respectively. Median BASDAI score was 4.3 [1-9.7]. Median JADAS10 score was 1[1-21].Overall, 45% of patients had osteoporosis, 27.5% had osteopenia, and 27.5 % had normal bone densitometry. None of the patients had a history of vertebral or peripheral fractures.Thirty per cent of patients (n=12) were on long term corticosteroid therapy with a mean dose of 6.6 ± 2.8 mg/day. Only 12.5% (n=5) of them had a regular physical activity.Osteoporosis was associated with age at JIA onset (p=0.005), disease duration (p=0.001), ESR (p=0.08), CRP (p=0.04), BASDAI score (p=0.017) and sedentarily (p=0.026). Osteopenia was only associated with corticosteroid therapy (p=0.01). Neither osteoporosis (p=0.37) nor Osteopenia (p=0.25) was associated with disease activity score.Conclusion:In our study, osteoporosis was a common feature during JIA. A long term corticosteroid therapy and sedentarily seem to be correlated with more impaired bone abnormalities. Hence, targeted interventions are urgently required to preserve bone health during JIA.References:[1]McDonagh JE. Osteoporosis in juvenile idiopathic arthritis. Curr Opin Rheumatol. 2001;13(5):399-404.Disclosure of Interests:None declared

Sign in / Sign up

Export Citation Format

Share Document