The Fasting Plasma Insulin Levels in Childhood Measured by Two Antibody Radioimmunoassay

In reply to Dr. Ehrlich's questions, we only wish that life would be as simple as he implied. The association of increased peripheral venous insulin values with islet cell adenoma is by no means universal in adults. In a child with multiple islet cell adenomata (Pediatrics, 39:59, 1967) , fasting plasma insulins as well as those following glucose, tolbutamide, and leucine, were not abnormally elevated. No other studies of peripheral or portal plasma insulin levels in infants or children with islet cell adenoma are known to us.

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Strength training increases insulin action in healthy 50- to 65-yr-old men

Journal of Applied Physiology ◽

10.1152/jappl.1994.77.3.1122 ◽

1994 ◽

Vol 77 (3) ◽

pp. 1122-1127 ◽

Cited By ~ 167

Author(s):

J. P. Miller ◽

R. E. Pratley ◽

A. P. Goldberg ◽

P. Gordon ◽

M. Rubin ◽

...

Keyword(s):

Strength Training ◽

Insulin Action ◽

Plasma Insulin ◽

Insulin Infusion ◽

Glucose Clamp ◽

Oral Glucose ◽

Insulin Levels ◽

Glucose Levels ◽

Fasting Plasma ◽

Plasma Insulin Levels

The insulin resistance associated with aging may be due, in part, to reduced levels of physical activity in the elderly. We hypothesized that strength training increases insulin action in older individuals. To test this hypothesis, 11 healthy men 50–63 yr old [mean 58 +/- 1 (SE) yr] underwent a two-step hyperinsulinemic-euglycemic glucose clamp with concurrent indirect calorimetry and an oral glucose tolerance test (OGTT) before and after 16 wk of strength training. The training program increased overall strength by 47% (P < 0.001). Fat-free mass (FFM; measured by hydrodensitometry) increased (62.4 +/- 2.1 vs. 63.6 +/- 2.1 kg; P < 0.05) and body fat decreased (27.2 +/- 1.8 vs. 25.6 +/- 1.9%; P < 0.001) with training. Fasting plasma glucose levels and glucose levels during the OGTT were not significantly lower after training. In contrast, fasting plasma insulin levels decreased (85 +/- 25 vs. 55 +/- 10 pmol/l; P < 0.05) and insulin levels decreased (P < 0.05, analysis of variance) during the OGTT. Glucose infusion rates during the hyperinsulinemic-euglycemic glucose clamp increased 24% (13.5 +/- 1.7 vs. 16.7 +/- 2.2 mumol.kg FFM-1.min-1; P < 0.05) during the low (20 mU.m-2.min-1) insulin infusion and increased 22% (55.7 +/- 3.3 vs. 67.7 +/- 3.9 mumol.kg FFM-1.min-1; P < 0.05) during the high (100 mU.m-2.min-1) insulin infusion. These increases were accompanied by a 40% increase (n = 7; P < 0.08) in nonoxidative glucose metabolism during the high insulin infusion. These results demonstrate that strength training increases insulin action and lowers plasma insulin levels in middle-aged and older men.

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Plasma Insulin Studies in the Diagnosis of Insulinoma

Scottish Medical Journal ◽

10.1177/003693306901400604 ◽

1969 ◽

Vol 14 (6) ◽

pp. 200-208 ◽

Cited By ~ 2

Author(s):

M. T. McKiddie ◽

K. D. Buchanan ◽

R. J. Abernethy

Keyword(s):

Plasma Insulin ◽

Insulin Response ◽

Insulin Level ◽

Oral Glucose ◽

False Negatives ◽

Insulin Levels ◽

Repeated Sampling ◽

High Insulin ◽

Plasma Insulin Levels ◽

Fasting Plasma Insulin

Plasma insulin levels were measured in 8 patients of whom 5 were surgically proven to have, and 3 had strongly suggestive evidence of, a functioning islet cell tumour. The fasting plasma insulin level was elevated in only 3 patients, despite repeated sampling. The administration of tolbutamide produced an excessive insulin response in 5 of the 8 patients, glucagon produced an excessive insulin response in 4 of 6 patients tested, 1-leucine produced a rise in plasma insulin in 1 of 2 subjects tested and the only subject studied after 50g. oral glucose had a high insulin response. The insulin response was highest after tolbutamide in all but one patient and this would appear to be the single most valuable test. However false negatives may occur and therefore the whole range of tests may have to be performed to establish the diagnosis. Two patients were studied during surgery and in one the insulin content of the tumour was assayed after extraction with acid alcohol. Four patients were studied again after treatment by surgery (2) and diazoxide (2) when normal insulin levels were found.

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Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes: Potential advantage? A randomized cross-over trial

PLoS ONE ◽

10.1371/journal.pone.0212013 ◽

2019 ◽

Vol 14 (3) ◽

pp. e0212013 ◽

Cited By ~ 2

Author(s):

Ulrike Schierloh ◽

Malgorzata E. Wilinska ◽

Ineke M. Pit-ten Cate ◽

Petra Baumann ◽

Roman Hovorka ◽

...

Keyword(s):

Type 1 Diabetes ◽

School Children ◽

Plasma Insulin ◽

Closed Loop ◽

Lower Plasma ◽

Insulin Levels ◽

Plasma Insulin Levels

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Metformin decreases plasma insulin levels and systolic blood pressure in spontaneously hypertensive rats

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1994.267.4.h1250 ◽

1994 ◽

Vol 267 (4) ◽

pp. H1250-H1253 ◽

Cited By ~ 5

Author(s):

S. Verma ◽

S. Bhanot ◽

J. H. McNeill

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

Spontaneously Hypertensive Rats ◽

Plasma Insulin ◽

Metformin Treatment ◽

Hypertensive Rats ◽

Spontaneously Hypertensive ◽

Insulin Levels ◽

Plasma Insulin Levels ◽

Wistar Kyoto

To determine the relationship between hyperinsulinemia and hypertension in spontaneously hypertensive rats (SHR), the antihyperglycemic agent metformin was administered to SHR and their Wistar-Kyoto (WKY) controls, and its effects on plasma insulin levels and blood pressure were examined. Five-week-old rats were started on oral metformin treatment (350 mg.kg-1.day-1, which was gradually increased to 500 mg.kg-1.day-1 over a 2-wk period). Metformin treatment caused sustained decreases in plasma insulin levels in the SHR (27.1 +/- 2.3 vs. untreated SHR 53.5 +/- 2.7 microU/ml, P < 0.001) without having any effect in the WKY (30.7 +/- 2.2 vs. untreated WKY 37.8 +/- 1.6 microU/ml, P > 0.05). The treatment did not affect the plasma glucose levels in any group. Metformin treatment also attenuated the increase in systolic blood pressure in the SHR (157 +/- 6.0 vs. untreated SHR 196 +/- 9.0 mmHg, P < 0.001) but had no effect in the WKY (134 +/- 3 vs. untreated WKY 136 +/- 4 mmHg, P > 0.05). Furthermore, raising plasma insulin levels in the metformin-treated SHR to levels that existed in the untreated SHR reversed the effect of metformin on blood pressure (189 +/- 3 vs. untreated SHR 208 +/- 5.0 mmHg, P > 0.05). These findings suggest that either hyperinsulinemia may contribute toward the increase in blood pressure in the SHR or that the underlying mechanism is closely associated with the expression of both these disorders.

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