The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain

2007 ◽  
Vol 25 (12) ◽  
pp. 3561-3569 ◽  
Author(s):  
Elizabeth A. Matthews ◽  
Lucy A. Bee ◽  
Gary J. Stephens ◽  
Anthony H. Dickenson
Keyword(s):  
Neuropathic Pain ◽  
Calcium Channel ◽  
Dorsal Horn ◽  
Rat Model ◽  
Calcium Channel Antagonist ◽  
Neuronal Responses ◽  
Chronic Neuropathic Pain

scholarly journals Wen-Luo-Tong Prevents Glial Activation and Nociceptive Sensitization in a Rat Model of Oxaliplatin-Induced Neuropathic Pain

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Bo Deng ◽  
Liqun Jia ◽  
Lin Pan ◽  
Aiping Song ◽  
Yuanyuan Wang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Horn ◽  
Rat Model ◽  
Spinal Dorsal Horn ◽  
Glial Activation ◽  
Painful Neuropathy ◽  
Chronic Neuropathic Pain ◽  
Excitatory Neurotransmitter ◽  
Nociceptive Sensitization ◽  
Spinal Dorsal

One of the main dose-limiting complications of the chemotherapeutic agent oxaliplatin (OXL) is painful neuropathy. Glial activation and nociceptive sensitization may be responsible for the mechanism of neuropathic pain. The Traditional Chinese Medicine (TCM) Wen-luo-tong (WLT) has been widely used in China to treat chemotherapy induced neuropathic pain. However, there is no study on the effects of WLT on spinal glial activation induced by OXL. In this study, a rat model of OXL-induced chronic neuropathic pain was established and WLT was administrated. Pain behavioral tests and morphometric examination of dorsal root ganglia (DRG) were conducted. Glial fibrillary acidic protein (GFAP) immunostaining was performed, glial activation was evaluated, and the excitatory neurotransmitter substance P (SP) and glial-derived proinflammatory cytokine tumor necrosis factor-α(TNF-α) were analyzed. WLT treatment alleviated OXL-induced mechanical allodynia and mechanical hyperalgesia. Changes in the somatic, nuclear, and nucleolar areas of neurons in DRG were prevented. In the spinal dorsal horn, hypertrophy and activation of GFAP-positive astrocytes were averted, and the level of GFAP mRNA decreased significantly. Additionally, TNF-αmRNA and protein levels decreased. Collectively, these results indicate that WLT reversed both glial activation in the spinal dorsal horn and nociceptive sensitization during OXL-induced chronic neuropathic pain in rats.

Activation of Astrocytes and Microglia in the C3–T4 Dorsal Horn by Lower Trunk Avulsion in a Rat Model of Neuropathic Pain

2013 ◽  
Vol 38 (5) ◽  
pp. 841-846 ◽  
Author(s):  
Ryutaro Iwasaki ◽  
Yusuke Matsuura ◽  
Seiji Ohtori ◽  
Takane Suzuki ◽  
Kazuki Kuniyoshi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Horn ◽  
Rat Model ◽  
Lower Trunk

Expression of spinal cord microRNAs in a rat model of chronic neuropathic pain

2012 ◽  
Vol 506 (2) ◽  
pp. 281-286 ◽  
Author(s):  
Timo Brandenburger ◽  
Mirco Castoldi ◽  
Maike Brendel ◽  
Hilbert Grievink ◽  
Lukas Schlösser ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Rat Model ◽  
Chronic Neuropathic Pain

scholarly journals A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation

2021 ◽  
Vol 17 ◽  
pp. 174480692110439
Author(s):  
Lonne Heijmans ◽  
Martijn R Mons ◽  
Elbert A Joosten
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Neuropathic Pain ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Serotonergic System ◽  
Chronic Neuropathic Pain ◽  
Spinal Dorsal ◽  
Important Target ◽  
Serotonergic Modulation

Chronic neuropathic pain is a debilitating ordeal for patients worldwide and pharmacological treatment efficacy is still limited. As many pharmacological interventions for neuropathic pain often fail, insights into the underlying mechanism and role of identified receptors is of utmost importance. An important target for improving treatment of neuropathic pain is the descending serotonergic system as these projections modulate nociceptive signaling in the dorsal horn. Also with use of last resort treatments like spinal cord stimulation (SCS), the descending serotonergic projections are known to be involved in the pain relieving effect. This systematic review summarizes the involvement of the serotonergic system on nociceptive modulation in the healthy adult rodent and the chronic neuropathic rodent and summarizes all available literature on the serotonergic system in the SCS-treated neuropathic rodent. Medline, Embase and Pubmed databases were used in the search for articles. Descending serotonergic modulation of nociceptive signaling in spinal dorsal horn in normal adult rat is mainly inhibitory and mediated by 5-HT1a, 5-HT1b, 5-HT2c, 5-HT3 and 5-HT4 receptors. Upon injury and in the neuropathic rat, this descending serotonergic modulation becomes facilitatory via activation of the 5-HT2a, 5-HT2b and 5-HT3 receptors. Analgesia due to neuromodulatory intervention like SCS restores the inhibitory function of the descending serotonergic system and involves 5-HT2, 5-HT3 and 5-HT4 receptors. The results of this systematic review provide insights and suggestions for further pharmacological and or neuromodulatory treatment of neuropathic pain based on targeting selected serotonergic receptors related to descending modulation of nociceptive signaling in spinal dorsal horn. With the novel developed SCS paradigms, the descending serotonergic system will be an important target for mechanism-based stimulation induced analgesia.

Sign in / Sign up

Export Citation Format

Share Document