Seasonal variations of urinary albumin creatinine ratio in Japanese subjects with Type 2 diabetes and early nephropathy

2012 ◽  
Vol 29 (4) ◽  
pp. 506-508 ◽  
Author(s):  
Y. Wada ◽  
Y. Hamamoto ◽  
H. Ikeda ◽  
S. Honjo ◽  
Y. Kawasaki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Seasonal Variations ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Japanese Subjects

Low plasma adiponectin levels predict increased urinary albumin/creatinine ratio in type 2 diabetes patients

2011 ◽  
Vol 44 (4) ◽  
pp. 1151-1157 ◽  
Author(s):  
I. Kacso ◽  
A. Lenghel ◽  
C. I. Bondor ◽  
D. Moldovan ◽  
C. Rusu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Plasma Adiponectin ◽  
Diabetes Patients

scholarly journals The Pattern of Plasma Gas-6 elevation among Type II Diabetes Mellitus Patients in Relation to Microalbuminuria using Urinary Albumin Creatinine Ratio

2020 ◽  
pp. 332-339
Author(s):  
AE Emedoh ◽  
Chukwudi Okani ◽  
FM Abbiyesuku
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Experimental Studies ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
College Hospital ◽  
Albumin Creatinine Ratio

Due to the global increase in diabetes, diabetic nephropathy is becoming a significant issue. Diagnosis and treatment in the early stages of nephropathy may avert this considerable complication, and new biomarkers other than microalbuminuria are required to detect diabetic nephropathy earlier in type 2 diabetes mellitus. Moreover, the pathogenesis of complications associated with diabetes as indicated in recent experimental studies showed that growth arrest-specific-6 protein (Gas-6) might have a role. We therefore, embarked on this study to determine the pattern of plasma Gas-6 elevation among type 2 diabetes mellitus patients and to describe any relationship with microalbuminuria using urinary albumin creatinine ratio. This research was a descriptive; a hospital-based cross-sectional study conducted at the Endocrinology Clinic, University College Hospital, Ibadan, Oyo State, Nigeria. We recruited 71 type-2 diabetic participants, and 71 apparently-healthy participants who served as the control. The study showed that the concentrations of Gas-6 protein and UACR in the diabetic participants were all significantly higher than in the healthy control participants (p ˂ 0.001). There was also a positive correlation between Gas-6 protein and UACR value which was statistically significant (rho = 0.41, p = ˂0.001). The sensitivity and specificity of Gas-6 was 75.0% and 19.1% respectively, with a PPV and NPV of 0.68 and 0.25 respectively. In conclusion, Plasma Gas-6protein correlated with microalbuminuria. However, Gas-6 protein alone may be of limited diagnostic value in diabetic nephropathy.

scholarly journals Administration of RAS Inhibitor before the Onset of Diabetic Nephropathy Counteracts the Adverse Effect of Chronic Hyperglycemia and Reduces the Augmentation of Urinary Albumin Excretion: A Retrospective Clinical Study

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Hidenori Hirukawa ◽  
Shinji Kamei ◽  
Tomohiko Kimura ◽  
Atsushi Obata ◽  
Kenji Kohara ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Albumin Excretion ◽  
Chronic Hyperglycemia ◽  
Retrospective Clinical Study ◽  
Japanese Subjects

It is very important to explore how we can reduce urinary albumin excretion which is an independent risk factor for ischemic heart disease. In this study, we retrospectively evaluated the effects of RAS inhibitor therapy on diabetic nephropathy in Japanese subjects whose urinary albumin levels were within normal range. We enrolled 100 subjects with type 2 diabetes who did not take any renin-angiotensin system (RAS) inhibitor. We defined the subjects taking RAS inhibitor for more than 3 years as RAS inhibitor group. RAS inhibitor exerted protective effect on the progression of urinary albumin excretion in subjects with type 2 diabetes without diabetic nephropathy. In addition, RAS inhibitor exerted more protective effects on renal function especially in subjects with poor glycemic control. In conclusion, RAS inhibitor could protect renal function against the deleterious effect of chronic hyperglycemia in Japanese subjects with type 2 diabetes even before the onset of diabetic nephropathy.

scholarly journals MICROALBUMINURIA;

2017 ◽  
Vol 24 (02) ◽  
pp. 221-227
Author(s):  
Ghazanfar Ali Sandhu ◽  
Ghulam Abbas Tahir ◽  
Zaheer Ahmad ◽  
Aqeel Maqsood Anjum
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
T Test ◽  
Losartan Potassium ◽  
P Value ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Significant Difference

Diabetes Mellitus is a rapidly increasing problem which is contributing tochronic illnesses like Cerebrovascular, Cardiovascular, Diabetic Retinopathy and End StageKidney Disease. These dreaded complications can be prevented if treated early. In patientswith diabetes mellitus type 2, microalbuminuria is an independent and strong risk factor forcardiovascular mortality & morbidity and diabetic nephropathy. If diagnosed early, diabeticnephropathy can be treated at this stage. Angiotensin converting enzyme inhibitors (ACEInhibitors) and Angiotensin Receptor Blockers (ARBs) are effective in prevention and treatmentof microalbuminuria. Material & Methods: Study Design: randomized controlled trial. Setting:medical department, allied hospital, Faisalabad. Duration of study: Feb 2013 to July 2013.Sample size: 60 (30 in each group). Sampling technique: Non-probability consecutivesampling. Results: 60 patients were included in the study. 28(46.7%) were males and 32(53.3%)were females. Mean age of study population was 50.15±7.27 years. Albumin creatinine ratio(mcg/mg) at start of study was 193±67.5 in Losartan potassium group and 209.5±72.00 inlisinopril group (independent sample t-test p value=0.302). Albumin creatinine ratio (mcg/mg) at 12 weeks of study was 36.33±54.68 in Losartan potassium group and 72±83.42 inlisinopril group (independent sample t-test p value = 0.056). Paired sample t test applied toboth treatment groups and p value was found to be 0.0001 which is highly significant for bothgroups and shows that both drugs are effective in reducing microalbuminuria in both groups.Microalbuminuria was reduced significantly in 26 patients (86.7%) in Losartan potassiumgroup and 20 patients (66.7%) in lisinopril group (p-value=0.067). Conclusion: It has beenconcluded from this study that lisinopril and Losartan potassium, both significantly reducemicroalbuminuria in type 2 diabetes mellitus and there is no statistically significant difference inefficacy of these two drugs in reducing microalbuminuria in type 2 diabetes mellitus.

scholarly journals Subtle decline in cardiac mechanics is correlated with albuminuria in asymptomatic normotensive patients with type 2 diabetes mellitus: a two-dimensional strain echocardiography study

2020 ◽  
Author(s):  
Sameh Samir Raafat ◽  
Nour Eldin M. Nazmy ◽  
Islam M. Bastawy ◽  
Yasser A. Abdellatif
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Longitudinal Strain ◽  
Systolic Dysfunction ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio

Abstract Background: Type 2 diabetes mellitus (T2DM) insidiously affects the myocardium with subsequent cardiomyopathy, it also pathologically involves the microvascular bed of the kidney reflected by albuminuria. This study aimed to investigate the relation between albuminuria and subclinical left ventricular (LV) systolic dysfunction in asymptomatic normotensive patients with T2DM assessed by two-dimensional (2D) speckle tracking echocardiography.Methods and results Sixty normotensive patients with T2DM, within 5 years of initial diagnosis, receiving conventional oral antidiabetic medications were included and subdivided into 2 subgroups, each including thirty patients according to the presence of albuminuria, together with thirty healthy control subjects all underwent full echocardiographic examination including left ventricular (LV) regional and global longitudinal strain (GLS) measurements. Laboratory tests including serum creatinine, glycated hemoglobin (HbA1C) and albumin creatinine ratio (ACR) were withdrawn for the three groups. There was a significant reduction in average peak systolic LV global longitudinal strain (GLS) in patients with T2DM when compared to control group (-16.18 ± 2.78% versus -18.13 ± 2.86%, P<0.001), however there was no significant difference in average peak systolic LV GLS between both diabetic subgroups (-15.57 ± 2.77% in subgroup with albuminuria versus -16.79 ± 2.70% in subgroup without albuminuria, p=0.077). Moreover, there was a significant correlation between ACR and reduction of GLS in patients with T2DM and albuminuria (r =0.38, P=0.003). However, this correlation was absent in patients with T2DM without albuminuria (r=0.107, P=0.573). Conclusion: Patients with type 2 diabetes mellitus (T2DM) have subclinical LV systolic dysfunction despite normal ejection fraction through reduction of average peak systolic LV GLS that is correlated with albumin creatinine ratio in patients with T2DM and albuminuria.

scholarly journals Effect of Glycosylated Hemoglobin with Microalbuminuria and Albumin Creatinine Ratio in Type 2 Diabetes

2021 ◽  
Vol 15 (7) ◽  
pp. 1974-1977
Author(s):  
Vitasari Indriani ◽  
Wahyu Siswandari ◽  
Andreas . ◽  
Tri Lestari
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Glycated Hemoglobin ◽  
Glycosylated Hemoglobin ◽  
Glycated Albumin ◽  
Diabetes Duration ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Detailed Medical History

Background: Diabetes mellitus has strong correlation with end stage renal disease (ESRD) and responsible for 30-40% of all ESRD cases.This study is focused on assessing the diabetic nephropathy status in patients with type 2 diabetes. Glycated hemoglobin levels over therapeutic targets (>7%) had two times the risk of complications for diabetic nephropathy, ISN recommends the use of microalbuminuria and urinary albumin creatinine ratio (UACR) for early detection of diabetic nephropathy and for monitoring therapy. Objective: This study was conducted to prove the correlation between Glycated Albumin with microalbuminuria and UACR in type 2 diabetes. Methods: Cross sectional study was done in70diabetic type 2 patients who attended PROLANIS program in Primary Health Care from May to November 2018.Detailed medical history including the diabetes duration and relevant clinical examination like FBS, PPBS, HbA1c, urinary creatinineand urinary microalbumin were recorded in each patient.Significance is assessed at 5% level of significance. Results: This study obtained the mean age of the study population was 51.89 ± 6.78 years with female preponderance (51.1%).Mean FBS, PPBS, HbA1c, duration of diabetes, blood pressure, microalbuminuria and urinary creatinine were182.51 ± 74.63 mg/dL, 186.25±26.72 mg/dL, 8.8 ± 1.83%, 9.37±5.96 years, 138.44±14, 13/84.44±19.25 mmHg,30.32±3.2 mg/day and 1.33±0.64 mg/dl respectively.Microalbuminuria (r=0.91, p≤0.05) and UACR (r=0.67, p≤0.05) were positively associated with glycated hemoglobin. Conclusion: It can be concluded that microalbuminuria level and ACR increase in line with the worsening of glycosylated hemoglobin and diabetes duration. Keywords: Albumin Creatinine Ratio; Diabetes; HbA1c; Microalbuminuria

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