Plasma Calcitonin Gene-Related Peptide in Diagnosing and Predicting Paediatric Migraine

Cephalalgia ◽  
2009 ◽  
Vol 29 (8) ◽  
pp. 883-890 ◽  
Author(s):  
P-C Fan ◽  
P-H Kuo ◽  
S-H Chang ◽  
W-T Lee ◽  
R-M Wu ◽  
...  
Keyword(s):  
Migraine Headache ◽  
Paired Comparison ◽  
Calcitonin Gene Related Peptide ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Samples ◽  
Related Peptide ◽  
Pediatric Migraine ◽  
Calcitonin Gene ◽  
Headache Patients

To investigate the role of plasma calcitonin gene-related peptide (CGRP) in paediatric migraine, we prospectively collected 134 blood samples during or between attacks from 66 migraine, 33 non-migraine headache (non-migraine) and 22 non-headache patients, aged 4–18 years. Plasma CGRP concentrations were measured by enzyme-linked immunosorbent assay and disability by Pediatric MIgraine Disability ASsessment (PedMIDAS) questionnaire. Migraineurs had higher plasma CGRP levels than non-migraine patients ( P = 0.007). The attack level was higher than the non-attack level in migraine ( P = 0.036), but not in non-migraine, patients. This was also revealed in paired comparison ( n = 9, P = 0.015 vs. n = 4, P = 0.47). Using a threshold of 55.1 pg/ml, the sensitivity of the attack level in predicting migraine was 0.81, and specificity 0.75. The PedMIDAS score tended to be higher in the high CGRP (> 200 pg/ml, n = 7) group than in the low (< 200 pg/ml, n = 33) group (26.07 vs. 19.32, P = 0.16) using Mann–Whitney test. Plasma CGRP is useful for diagnosis in paediatric migraine.

Plasma Changes of Calcitonin Gene-Related Peptide and Substance P in Patients with Dialysis Headache

Cephalalgia ◽  
2006 ◽  
Vol 26 (11) ◽  
pp. 1287-1293 ◽  
Author(s):  
M Alessandri ◽  
L Massanti ◽  
P Geppetti ◽  
G Bellucci ◽  
M Cipriani ◽  
...  
Keyword(s):  
Substance P ◽  
Plasma Concentrations ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Biochemical Factor ◽  
Before And After ◽  
Basal Plasma ◽  
Headache Patients

Little is known of mechanism of dialysis headache (DH). As suggested for migraine, a role for neuropeptides has been investigated. Twenty-four patients under haemodialysis were studied. Twelve of them suffered from DH. The remaining patients were headache free. Blood samples for radioimmunoassay of calcitonin gene-related peptide (CGRP) and substance P (SP) were collected from the arteriovenous fistula before and after dialysis treatment. Basal plasma concentrations of CGRP were found to be higher in headache patients. Dialysis significantly decreased CGRP concentrations in both groups. No difference in basal plasma concentrations of SP was observed between groups. At the end of the treatment plasma SP concentrations were reduced in headache-free patients but increased in headache patients. Elevated plasma concentrations of CGRP in patients with DH could represent a biochemical factor contributing to susceptibility to headache. Because of the disputable role of SP in migraine, the significance of the increase of the peptide in plasma during DH remains to be elucidated.

Role of calcitonin gene-related peptide in energy metabolism

Endocrine ◽  
2017 ◽  
Vol 58 (1) ◽  
pp. 3-13 ◽  
Author(s):  
William Gustavo Lima ◽  
Gleuber Henrique Marques-Oliveira ◽  
Thaís Marques da Silva ◽  
Valéria Ernestânia Chaves
Keyword(s):  
Energy Metabolism ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Role of calcitonin gene-related peptide in gastric hypersensitivity in rats

2006 ◽  
Vol 14 (25) ◽  
pp. 2484
Author(s):  
Fei-Fei Zhang ◽  
Jian-Zhong Mo ◽  
You-Ling Lv ◽  
Sheng-Liang Chen ◽  
Ming Lv ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors

2021 ◽  
Vol 8 ◽  
Author(s):  
Giuseppe Deganutti ◽  
Silvia Atanasio ◽  
Roxana-Maria Rujan ◽  
Patrick M. Sexton ◽  
Denise Wootten ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Ligand Binding ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Approved Drugs ◽  
G Protein Coupled ◽  
Dynamic Docking ◽  
Receptor Family

Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones. An understanding of how agonists bind and activate class B1 GPCRs is fundamental for the development of therapeutic small molecules. We combined supervised molecular dynamics (SuMD) and classic molecular dynamics (cMD) simulations to study the binding of the calcitonin gene-related peptide (CGRP) to the CGRP receptor (CGRPR). We also evaluated the association and dissociation of the antagonist telcagepant from the extracellular domain (ECD) of CGRPR and the water network perturbation upon binding. This study, which represents the first example of dynamic docking of a class B1 GPCR peptide, delivers insights on several aspects of ligand binding to CGRPR, expanding understanding of the role of the ECD and the receptor-activity modifying protein 1 (RAMP1) on agonist selectivity.

Effects of calcitonin gene-related peptide on vascular resistance in rats: role of sex steroids

1999 ◽  
Vol 276 (6) ◽  
pp. H2063-H2068 ◽  
Author(s):  
Michelle Grewal ◽  
Janis Cuevas ◽  
Gautam Chaudhuri ◽  
Lauren Nathan
Keyword(s):  
Sex Steroids ◽  
Perfusion Pressure ◽  
Pressor Response ◽  
Calcitonin Gene Related Peptide ◽  
Ovariectomized Rats ◽  
Synthesis Inhibitor ◽  
Pregnant Rats ◽  
Related Peptide ◽  
Calcitonin Gene

It has been demonstrated in reflex-intact animals that the sensitivity to calcitonin gene-related peptide (CGRP) is increased during pregnancy and that this action is mediated by sex steroids but not by nitric oxide (NO). We assessed the effects of CGRP in the following groups of anesthetized ganglion-blocked rats: 1) pregnant, 2) ovariectomized, and 3) ovariectomized and treated with estradiol and progesterone. Changes in mean arterial pressure (MAP) were assessed after the administration of varying doses of CGRP. Decreases in MAP after CGRP administration were significantly greater in pregnant rats and ovariectomized rats administered sex steroids than in ovariectomized controls. The CGRP antagonist CGRP8–37 produced a pressor response of similar magnitude in both pregnant and ovariectomized rats. We also assessed the effects of CGRP and the modulating role of NO in the isolated uterine vascular bed preparation. CGRP reduced perfusion pressure to a greater degree in ovariectomized animals treated with sex steroids than in ovariectomized animals. This response was attenuated by pretreatment with an NO synthesis inhibitor. CGRP8–37 produced a similar increase in perfusion pressure in both groups. We conclude that 1) the increased vascular sensitivity observed during pregnancy or after treatment with sex steroids is in part mediated by NO, and 2) CGRP8–37 has a vasoconstrictor action of its own.

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