Secondary intention healing in skin surgery: our own experience and expanded indications in hidradenitis suppurativa, rhinophyma and non-melanoma skin cancers

2012 ◽  
Vol 27 (8) ◽  
pp. 1015-1021 ◽  
Author(s):  
A. Bieniek ◽  
Ł. Matusiak ◽  
I. Chlebicka ◽  
J.C. Szepietowski
Keyword(s):  
Hidradenitis Suppurativa ◽  
Secondary Intention ◽  
Skin Cancers ◽  
Skin Surgery ◽  
Melanoma Skin

scholarly journals PD-1 and beyond to Activate T Cells in Cutaneous Squamous Cell Cancers: The Case for 4-1BB and VISTA Antibodies in Combination Therapy

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3310
Author(s):  
Quentin Wright ◽  
Jazmina L. Gonzalez Cruz ◽  
James W. Wells ◽  
Graham R. Leggatt
Keyword(s):  
Squamous Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Treatment Modalities ◽  
Immune Memory ◽  
Skin Cancers ◽  
Promising Therapeutic Approach ◽  
Localized Disease ◽  
Skin Surgery ◽  
Melanoma Skin

Non-melanoma skin cancers (NMSC) have a higher incidence than all other cancers combined with cutaneous squamous cell carcinoma (cSCC), capable of metastasis, representing approximately 20% of NMSCs. Given the accessibility of the skin, surgery is frequently employed to treat localized disease, although certain localities, the delineation of clear margins, frequency and recurrence of tumors can make these cancers inoperable in a subset of patients. Other treatment modalities, including cryotherapy, are commonly used for individual lesions, with varying success. Immunotherapy, particularly with checkpoint antibodies, is increasingly a promising therapeutic approach in many cancers, offering the potential advantage of immune memory for protection against lesion recurrence. This review addresses a role for PD-1, 4-1BB and VISTA checkpoint antibodies as monotherapies, or in combination as a therapeutic treatment for both early and late-stage cSCC.

scholarly journals KID Syndrome and Hidradenitis Suppurativa: A Rare Association Responding to Surgical Treatment

2020 ◽  
pp. 1-4
Author(s):  
Vincenzo Bettoli ◽  
Riccardo Forconi ◽  
Ilaria Pezzini ◽  
Ruby Martinello ◽  
Valeria Scuderi ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Rare Case ◽  
Hidradenitis Suppurativa ◽  
Skin Involvement ◽  
Cutaneous Infections ◽  
Rare Association ◽  
Secondary Intention ◽  
Skin Cancers ◽  
Auditory Impairment ◽  
Results Of Surgery

<b><i>Background:</i></b> Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis characterized by keratitis, neurosensorial auditory impairment and ichthyosiform skin involvement. Frequent complications of the syndrome are chronic, opportunistic cutaneous infections, and the development of skin cancers. Several cases of association between KID syndrome and other conditions, including hidradenitis suppurativa (HS), are described in the literature. This correlation could be explained by the hyperproliferative state of the epidermis, which occurs in KID syndrome and may favor follicular plugging. <b><i>Objectives:</i></b> The aim of this study was to describe a very rare case of association between KID syndrome and HS and its complex therapeutic management. <b><i>Results:</i></b> The failure of the drugs commonly used in HS and the excellent results of surgery, although difficult to achieve, were experienced. <b><i>Conclusion:</i></b> Despite the technical difficulties related to surgery, namely, cutaneous superinfections, frequent dehisce of the suture, and closure by secondary intention, the authors strongly recommend the surgical approach in these patients.

Skull Base and Intracranial Invasion Patterns and Survival Outcomes of Non-Melanoma Skin Cancers

2016 ◽  
Vol 77 (S 01) ◽  
Author(s):  
Yusuf Dundar ◽  
Richard Cannon ◽  
Marcus Monroe ◽  
Luke Buckman ◽  
Jason Hunt
Keyword(s):  
Skull Base ◽  
Survival Outcomes ◽  
Skin Cancers ◽  
Invasion Patterns ◽  
Melanoma Skin

Investigative Landscape in Advanced Non-Melanoma Skin Cancers

2021 ◽  
Vol 22 (7) ◽  
Author(s):  
Priyanka Reddy ◽  
Min Yao ◽  
Monaliben Patel
Keyword(s):  
Skin Cancers ◽  
Melanoma Skin

Systemic Therapy for Head and Neck Skin Cancers

FACE ◽  
2021 ◽  
pp. 273250162110138
Author(s):  
Rebecca Knackstedt ◽  
Peter Taub ◽  
Gary Rogers ◽  
Brian Gastman
Keyword(s):  
Radiation Therapy ◽  
High Risk ◽  
Head And Neck ◽  
Systemic Therapy ◽  
Malignant Tumors ◽  
Curative Therapy ◽  
Recurrent Tumors ◽  
Skin Cancers ◽  
Systemic Therapies ◽  
Melanoma Skin

The mainstay of curative therapy for head and neck skin cancers relies upon surgery and/or radiation therapy. However, for some aggressive, non-resectable or recurrent tumors, systemic therapy is necessary. Recent emerging classes of drugs have shown to improve survival for high-risk, recurrent, and unresectable variants of these tumors. The goal of this paper is to review options for systemic therapies for head and neck skin cancers including melanoma, non-melanoma skin cancers and other rare and non-malignant tumors.

scholarly journals Comparative Aspects of Melanoma and Non-Melanoma Skin Cancers in Japan

1989 ◽  
Vol 92 (5) ◽  
pp. S204-S209 ◽  
Author(s):  
Shigeo Ikeda ◽  
Yoshio Kiyohara ◽  
Hiromi Mizutani
Keyword(s):  
Skin Cancers ◽  
Melanoma Skin

scholarly journals A Case of Squamous Cell Carcinoma of Skin Subsequent to Subcutaneous Foreign Body

2016 ◽  
Vol 12 (1) ◽  
pp. 53-55
Author(s):  
P Anwar ◽  
S Mubashir ◽  
I Hassa ◽  
T Arif
Keyword(s):  
Squamous Cell Carcinoma ◽  
Foreign Body ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Foreign Bodies ◽  
Transposition Flap ◽  
Skin Cancers ◽  
Flap Closure ◽  
Melanoma Skin

Squamous cell carcinoma (SCC) of the skin is one of the most common non melanoma skin cancers (NMSC), along with basal cell carcinoma (BCC). Besides ultraviolet radiation, the role of exposure to industrial agents, ionizing radiation and areas of chronic inflammation is associated with the development of SCC. SCC may also be associated with foreign bodies. We report a rare case of cutaneous SCC in an elderly Kashmiri female, developing subsequent to subcutaneous non metallic foreign body, which was successfully excised with negative margins, and transposition flap closure. DOI: http://dx.doi.org/10.3126/njdvl.v12i1.10604 Nepal Journal of Dermatology, Venereology & Leprology Vol.12(1) 2014 pp.53-55

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