scholarly journals Decreased Response of Rat Knee Joint Blood Vessels to Phenylephrine in Chronic Inflammation: Involvement of Nitric Oxide

2000 ◽  
Vol 85 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Mohammad Badavi ◽  
Ali Khoshbaten ◽  
Sohrab Hajizadeh
Keyword(s):  
Nitric Oxide ◽  
Knee Joint ◽  
Blood Vessels ◽  
Chronic Inflammation

In Vivo Spin Trapping of Glyceryl Trinitrate–Derived Nitric Oxide in Rabbit Blood Vessels and Organs

Circulation ◽  
1995 ◽  
Vol 92 (7) ◽  
pp. 1876-1882 ◽  
Author(s):  
Alexander Mülsch ◽  
Peter Mordvintcev ◽  
Eberhard Bassenge ◽  
Frank Jung ◽  
Bernd Clement ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glyceryl Trinitrate ◽  
Blood Vessels ◽  
Spin Trapping ◽  
Rabbit Blood

CGRP modulates nerve-mediated vasoconstriction of rat knee joint blood vessels

1991 ◽  
Vol 34 (2) ◽  
pp. 118 ◽  
Author(s):  
F.Y. Lam ◽  
W.R. Ferrell
Keyword(s):  
Knee Joint ◽  
Blood Vessels

Histological Features of Osteoarthritis in a State of Decompensation

2021 ◽  
Vol 53 ◽  
pp. 51-58
Author(s):  
Timur B. Minasov ◽  
Ekaterina R. Yakupova ◽  
Dilmurod Ruziboev ◽  
Ruslan M. Vakhitov-Kovalevich ◽  
Ruslan F. Khairutdinov ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Blood Vessels ◽  
Subchondral Bone ◽  
Musculoskeletal System ◽  
Hyaline Cartilage ◽  
Material Selection ◽  
Central Zone ◽  
Cartilage Tissue ◽  
Social Significance

Degenerative pathology of the musculoskeletal system is one of the main reasons for decreased mobility in patients of the older age group. Increasing the life expectancy leads to predominance non-epidemic pathology in all developed countries. Therefore, degenerative diseases of musculoskeletal system have not only medical significance but also social significance. Objective is studying the morphological features of synovial environment of the decompensated osteoarthritic (OA) knee joint. Structural features of subchondral bone, hyaline cartilage of the femur and tibia, the articular capsule, menisci and ligamentous apparatus of the knee joint were studied in 64 patients who underwent total knee arthroplasty at the Department of Traumatology and Orthopedics Bashkirian State Medical University in the period from 2015 to 2020. Material selection, preparation of histological samples, staining with hematoxylin-eosin, microscopy was performed. Adaptive signs of articular cartilage of the femoral condyles manifest in the form of cartilage tissue rearrangement, which are most pronounced in the central zone of the cartilage. At the same time, the phenomena of decompensation and significant areas of destruction are noted. Also, the subchondral bone was replaced with connective tissue with subsequent sclerosis. This sclerosis subsequently led to the decompensation of structures of the hyaline cartilage in the deep and middle zones. Destructive and dystrophic processes were noted in the knee joint menisci. Articular cartilage was replaced with granulation tissue with subsequent invasion of blood vessels. Cruciate ligaments in patients with OA show signs of adaptation due to expansion of endothenonium layers between bundles of collagen fibers and an increase in the diameter of blood vessels.

scholarly journals Pengamatan histopatologis pulpa gigi M. nemestrina yang terpapar getah J. curcas

2008 ◽  
Vol 7 (1) ◽  
pp. 19
Author(s):  
Indrya Kirana Mattulada
Keyword(s):  
Red Blood Cells ◽  
Blood Vessels ◽  
Chronic Inflammation ◽  
Blood Cells ◽  
Chronic Condition ◽  
Acute Inflammation ◽  
Anti Inflammation

Tooth pain can be overcame by analgetics oraly or topically applied in the toothcavity. One of the topical analgetic is latex of J. Curcas. The purpose of this study wasto evaluate the anti inflammation effect of the latex of J. Curcas under histopathologicobservation. Twenty two teeth of M. Nemestrina were prepared until perforation,then applied the lyophilized latex of J. Curcas into the cavity and covered bytemporary filling.Eugenol was used as comparison. Evaluation was carried out after3, 6 and 24 hours. Monkeys were euthanized and the teeth were extracted. Antiinflammation effect was evaluated under histopathology observation. The result of thisstudy show red blood cells and acute inflammation were found under 3 and 6 hoursobservation, while odontoblastvacuolization cells and lysis of the blood vessels. Theconclusion was chronic inflammation occured might explain pulp pain relieved due tothe the chronic condition followed

scholarly journals Microvasculature of Anterior Cruciate Ligament by Immunohistochemistry using VE-Cadherin

2020 ◽  
Vol 6 (1) ◽  
pp. 58-61
Author(s):  
Jahira Banu T ◽  
Yogesh Ashok Sontakke
Keyword(s):  
Anterior Cruciate Ligament ◽  
Postoperative Complications ◽  
Knee Joint ◽  
Blood Vessels ◽  
Transmembrane Protein ◽  
Femoral Condyle ◽  
Cruciate Ligament ◽  
Middle Part ◽  
The Past ◽  
Anterior Cruciate

Introduction: The anterior cruciate ligament (ACL) is one of the knee stabilizer and acts to prevent excessive anterior mobility as well as rotational movement. The ACL is extending from the lateral femoral condyle to the anterior intercondylar area of tibia. During excessive movement or abnormal mobility affecting the knee joint, the ACL is under tension and prone for injury. The injured ACL was managed by surgery as it was an option for treatment owing to its poor vascularity. The distribution of the blood vessels within the ACL was not clear and only few studies reported in the past. The present study focused on distribution of blood vessels in the ACL. Subjects and Methods: The ACL microvasculature was assessed using 48 cadaveric ACL tissues using immunohistochemistry. The antibody against the transmembrane protein VE-Cadherin was targeted to study the blood vessels. Results: It was observed that the middle part of the ACL was less vascular compared with the peripheral parts of ACL. Conclusion: The knowledge of the ACL vasculature may help in planning surgeries of ACL to reduce postoperative complications.

scholarly journals Transient Focal Ischemia Increases Endothelial Nitric Oxide Synthase in Cerebral Blood Vessels

Stroke ◽  
2002 ◽  
Vol 33 (11) ◽  
pp. 2704-2710 ◽  
Author(s):  
Roland Veltkamp ◽  
Nishadi Rajapakse ◽  
Greg Robins ◽  
Michelle Puskar ◽  
Katsuyoshi Shimizu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Blood Vessels ◽  
Endothelial Nitric Oxide Synthase ◽  
Focal Ischemia ◽  
Cerebral Blood Vessels ◽  
Transient Focal Ischemia ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation

2020 ◽  
Vol 193 ◽  
pp. 112216 ◽  
Author(s):  
Youzhe Yang ◽  
Zhe Wei ◽  
Alexander Tobias Teichmann ◽  
Frank Heinrich Wieland ◽  
Amu Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Inflammation ◽  
Therapeutic Effect ◽  
No Production

scholarly journals Endothelium and nitric oxide

Medicina ◽  
2008 ◽  
Vol 44 (7) ◽  
pp. 564 ◽  
Author(s):  
Vida Garalienė
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Blood Vessels ◽  
Leukocyte Adhesion ◽  
Endothelial Permeability ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Short Review ◽  
Isosorbide Mononitrate ◽  
Nitric Oxide Donors ◽  
Converting Enzyme Inhibitors

Studied nature of the “blood vessels relaxing factor” derived fromendotheliumthat was identified as nitric oxide caused intensive scientific research on nitric oxide regarding some aspects of its impact on human physiological and pathological processes. The objective of this short review is to discuss widely used (in the clinical practice) direct and indirect donors of nitric oxide and/or other agents, increasing nitric oxide concentration in human body, and their beneficial role for the prevention of atherosclerosis. Under physiological conditions, endotheliumregulates the tone of blood vessels, homeostasis of which is maintained by endotheliumgenerated vasoconstrictors and vasodilators. The most important vasodilator and the main substance produced by the endothelium is nitric oxide. The failure of synthesis and/or the lost of nitric oxide bioavailability is the major feature of endothelial dysfunction and key factor initiating progression of atherosclerosis. The endothelial dysfunction initiates the series of events, which stimulate and aggravate the course of atherosclerosis by increasing endothelial permeability, platelet aggregation, and leukocyte adhesion, and cytokine expression. Further, the review deals with the mechanisms of action of statins, angiotensin-converting enzyme inhibitors, L-arginine, direct nitric oxide donors (nitroglycerin, isosorbide mononitrate and isosorbide dinitrate), and indirect nitric oxide donors (phosphodiesterase-V inhibitors, KATP openers).

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