Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator?monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease

Yael Avramovich-Tirosh; Tamar Amit; Orit Bar-Am; Hailin Zheng; Mati Fridkin; Moussa B. H. Youdim

doi:10.1111/j.1471-4159.2006.04258.x

Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator?monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2006.04258.x ◽

2007 ◽

Vol 100 (2) ◽

pp. 490-502 ◽

Cited By ~ 87

Author(s):

Yael Avramovich-Tirosh ◽

Tamar Amit ◽

Orit Bar-Am ◽

Hailin Zheng ◽

Mati Fridkin ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Therapeutic Targets ◽

Iron Chelator ◽

Oxidase Inhibitor ◽

The Novel ◽

Inhibitor Drug

Download Full-text

Brain catalase in the streptozotocin-rat model of sporadic Alzheimer’s disease treated with the iron chelator–monoamine oxidase inhibitor, M30

Journal of Neural Transmission ◽

10.1007/s00702-014-1307-y ◽

2014 ◽

Vol 122 (4) ◽

pp. 559-564 ◽

Cited By ~ 10

Author(s):

E. Sofic ◽

M. Salkovic-Petrisic ◽

I. Tahirovic ◽

A. Sapcanin ◽

S. Mandel ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Rat Model ◽

Monoamine Oxidase Inhibitor ◽

Iron Chelator ◽

Oxidase Inhibitor ◽

Sporadic Alzheimer’S Disease ◽

Streptozotocin Rat Model

Download Full-text

Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer’s disease

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.04.009 ◽

2015 ◽

Vol 23 (13) ◽

pp. 3722-3729 ◽

Cited By ~ 26

Author(s):

Shishun Xie ◽

Jie Chen ◽

Xiruo Li ◽

Tao Su ◽

Yali Wang ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Oxidase Inhibitor ◽

Metal Chelator

Download Full-text

Restoration of Nigrostriatal Dopamine Neurons in Post-MPTP Treatment by the Novel Multifunctional Brain-Permeable Iron Chelator-Monoamine Oxidase Inhibitor Drug, M30

Neurotoxicity Research ◽

10.1007/s12640-009-9070-9 ◽

2009 ◽

Vol 17 (1) ◽

pp. 15-27 ◽

Cited By ~ 47

Author(s):

Shunit Gal ◽

Hailin Zheng ◽

Mati Fridkin ◽

Moussa B. H. Youdim

Keyword(s):

Monoamine Oxidase Inhibitor ◽

Iron Chelator ◽

Oxidase Inhibitor ◽

Dopamine Neurons ◽

The Novel ◽

Nigrostriatal Dopamine ◽

Mptp Treatment ◽

Inhibitor Drug ◽

Nigrostriatal Dopamine Neurons ◽

Permeable Iron

Download Full-text

Analysis of the serum isatin, an endogenous monoamine oxidase inhibitor, in aging and Alzheimer's disease

Journal of the Neurological Sciences ◽

10.1016/j.jns.2017.08.654 ◽

2017 ◽

Vol 381 ◽

pp. 228-229

Author(s):

N. Hamaue ◽

A. Ogata ◽

S. Tsuchida ◽

T. Aoki

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Oxidase Inhibitor

Download Full-text

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2005.03341.x ◽

2005 ◽

Vol 95 (1) ◽

pp. 79-88 ◽

Cited By ~ 140

Author(s):

Shunit Gal ◽

Hailin Zheng ◽

Mati Fridkin ◽

Moussa B. H. Youdim

Keyword(s):

Monoamine Oxidase ◽

Neurodegenerative Diseases ◽

Monoamine Oxidase Inhibitor ◽

Iron Chelator ◽

Oxidase Inhibitor ◽

Dopamine Depletion ◽

Monoamine Oxidase Inhibition ◽

Oxidase Inhibition ◽

Striatal Dopamine Depletion

Download Full-text

The Novel Multi-Target Iron Chelator, M30 Modulates HIF-1α-Related Glycolytic Genes and Insulin Signaling Pathway in the Frontal Cortex of APP/PS1 Alzheimer’s Disease Mice

Current Alzheimer Research ◽

10.2174/1567205010666131212112529 ◽

2014 ◽

Vol 11 (2) ◽

pp. 119-127 ◽

Cited By ~ 14

Author(s):

Danit Mechlovich ◽

Tamar Amit ◽

Orit Bar-Am ◽

Silvia Mandel ◽

Moussa Youdim ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Frontal Cortex ◽

Signaling Pathway ◽

Insulin Signaling ◽

Iron Chelator ◽

Insulin Signaling Pathway ◽

The Novel

Download Full-text

The neurochemical and behavioral effects of the novel cholinesterase-monoamine oxidase inhibitor, ladostigil, in response to L -dopa and L -tryptophan, in rats

British Journal of Pharmacology ◽

10.1038/sj.bjp.0706355 ◽

2005 ◽

Vol 146 (4) ◽

pp. 553-560 ◽

Cited By ~ 18

Author(s):

Yotam Sagi ◽

Noam Driguès ◽

Moussa B H Youdim

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Oxidase Inhibitor ◽

Behavioral Effects ◽

The Novel

Download Full-text

The Novel Cholinesterase–Monoamine Oxidase Inhibitor and Antioxidant, Ladostigil, Confers Neuroprotection in Neuroblastoma Cells and Aged Rats

Journal of Molecular Neuroscience ◽

10.1007/s12031-008-9139-6 ◽

2008 ◽

Vol 37 (2) ◽

pp. 135-145 ◽

Cited By ~ 41

Author(s):

Orit Bar-Am ◽

Orly Weinreb ◽

Tamar Amit ◽

Moussa B. H. Youdim

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Neuroblastoma Cells ◽

Oxidase Inhibitor ◽

The Novel ◽

Aged Rats

Download Full-text

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2005.03340.x ◽

2005 ◽

Vol 95 (1) ◽

pp. 68-78 ◽

Cited By ~ 148

Author(s):

Hailin Zheng ◽

Shunit Gal ◽

Lev M. Weiner ◽

Orit Bar-Am ◽

Abraham Warshawsky ◽

...

Keyword(s):

Antioxidant Activity ◽

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Lipid Peroxide ◽

Iron Chelator ◽

Oxidase Inhibitor ◽

Monoamine Oxidase Inhibition ◽

Peroxide Formation ◽

Oxidase Inhibition

Download Full-text

Faculty Opinions recommendation of Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718010574.793476741 ◽

2013 ◽

Author(s):

Laetitia Davidovic

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Early Diagnosis ◽

Human Brain ◽

Therapeutic Targets

Download Full-text