Serotonin transporter function, but not expression, is dependent on brain-derived neurotrophic factor (BDNF): in vivo studies in BDNF-deficient mice

2007 ◽  
Vol 101 (3) ◽  
pp. 641-651 ◽  
Author(s):  
L. C. Daws ◽  
J. L. Munn ◽  
M. F. Valdez ◽  
T. Frosto-Burke ◽  
J. G. Hensler
Keyword(s):  
Serotonin Transporter ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
In Vivo Studies ◽  
Deficient Mice

scholarly journals Interferon beta-1a induces expression of brain-derived neurotrophic factor in human T lymphocytes in vitro and not in vivo

2020 ◽  
Vol 15 (1) ◽  
pp. FNL38 ◽  
Author(s):  
Zarlascht Karmand ◽  
Hans-Peter Hartung ◽  
Oliver Neuhaus
Keyword(s):  
T Cell ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Peripheral Blood Lymphocytes ◽  
T Cell Proliferation ◽  
Bdnf Expression ◽  
Healthy Donors

Aim: To detect IFN β-1a-induced expression of brain-derived neurotrophic factor (BDNF) to undermine the hypothesis of IFN β-1a-associated neuroprotection in multiple sclerosis (MS). Methods: The influence of IFN β-1a on in vitro activated peripheral blood lymphocytes from healthy donors was tested. Proliferation analyses were made to detect T-cell growth. BDNF expression was measured by standard ELISA. To assess the influence of IFN β-1a on BDNF expression in vivo, BDNF serum levels of MS patients treated with IFN β-1a were compared with those of untreated patients. Results: IFN β-1a inhibited T-cell proliferation dose dependently. It induced BDNF expression at middle concentrations. MS patients treated with IFN β-1a exhibited significantly lower BDNF serum levels than untreated patients. Conclusion: IFN β-1a may promote neuroprotection by inducing BDNF expression, but its importance in vivo remains open.

Striatum brain-derived neurotrophic factor levels are decreased in dystrophin-deficient mice

2009 ◽  
Vol 459 (2) ◽  
pp. 66-68 ◽  
Author(s):  
Clarissa M. Comim ◽  
Lisiane Tuon ◽  
Laura Stertz ◽  
Mariz Vainzof ◽  
Flávio Kapczinski ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Deficient Mice

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

Neuron ◽  
1993 ◽  
Vol 10 (3) ◽  
pp. 359-367 ◽  
Author(s):  
Vassilis E. Koliatsos ◽  
Richard E. Clatterbuck ◽  
John W. Winslow ◽  
Michelle H. Cayouette ◽  
Donald L. Prices
Keyword(s):  
Motor Neurons ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Trophic Factor
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