scholarly journals Involvement of the 3′-untranslated region of the brain-derived neurotrophic factor gene in activity-dependent mRNA stabilization

2010 ◽  
Vol 115 (5) ◽  
pp. 1222-1233 ◽  
Author(s):  
Mamoru Fukuchi ◽  
Masaaki Tsuda
Keyword(s):  
Neurotrophic Factor ◽  
Untranslated Region ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Gene ◽  
Mrna Stabilization ◽  
Activity Dependent ◽  
The Brain

Brain-Derived Neurotrophic Factor Systemic Response in the Periodontium, Trigeminal Nucleus Caudalis, and Hippocampus Induced by Occlusal Trauma

2021 ◽  
Vol 17 (7) ◽  
pp. 1371-1379
Author(s):  
Di Liu ◽  
Ying Li ◽  
Jiechen Liu ◽  
Zhiyuan Shen ◽  
Fengying Wang ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Systemic Response ◽  
Periodontal Tissue ◽  
Trigeminal Nucleus ◽  
Bdnf Gene ◽  
Dental Tissue ◽  
Injury And Repair ◽  
Activity Dependent ◽  
The Brain

Occlusal trauma (OT), by causing periodontal tissue damage, can activate and enhance the activity of the peripheral and central nervous system (CNS) neuropeptides. The brain-derived neurotrophic factor (BDNF) gene is activity-dependent and exhibits marked alterations, characterized by protection against injury and repair. Our results show the possible molecular mechanism through which noxious environmental stimuli induce alterations in BDNF activity in the local periodontal tissue, the primary sensory neurons-Vc, and the hippocampus, suggesting systemic impairment. BDNF serves a more positive and enduring trauma protection and repair function in Vc compared to that in local dental tissue.

Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder

2010 ◽  
Vol 125 (1-3) ◽  
pp. 345-349 ◽  
Author(s):  
Georgina M. Hosang ◽  
Rudolf Uher ◽  
Robert Keers ◽  
Sarah Cohen-Woods ◽  
Ian Craig ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Life Events ◽  
Neurotrophic Factor ◽  
Stressful Life Events ◽  
Brain Derived Neurotrophic Factor ◽  
Stressful Life ◽  
Factor Gene ◽  
The Brain

Prophylactic Lithium Response and Polymorphism of the Brain-Derived Neurotrophic Factor Gene

2005 ◽  
Vol 38 (4) ◽  
pp. 166-170 ◽  
Author(s):  
J. K. Rybakowski ◽  
A. Suwalska ◽  
M. Skibinska ◽  
A. Szczepankiewicz ◽  
A. Leszczynska-Rodziewicz ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Gene ◽  
Lithium Response ◽  
The Brain

Observed parenting behaviors interact with a polymorphism of the brain-derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous–unemotional behaviors at age 3 years

2013 ◽  
Vol 25 (4pt1) ◽  
pp. 903-917 ◽  
Author(s):  
Michael T. Willoughby ◽  
Roger Mills-Koonce ◽  
Cathi B. Propper ◽  
Daniel A. Waschbusch
Keyword(s):  
Child Health ◽  
Disruptive Behavior ◽  
Neurotrophic Factor ◽  
Parenting Behaviors ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Gene ◽  
Callous Unemotional ◽  
Oppositional Defiant ◽  
Health And Development ◽  
The Brain

AbstractUsing the Durham Child Health and Development Study, this study (N = 171) tested whether observed parenting behaviors in infancy (6 and 12 months) and toddlerhood/preschool (24 and 36 months) interacted with a child polymorphism of the brain-derived neurotrophic factor gene to predict oppositional defiant disorder (ODD) and callous–unemotional (CU) behaviors at age 3 years. Child genotype interacted with observed harsh and intrusive (but not sensitive) parenting to predict ODD and CU behaviors. Harsh–intrusive parenting was more strongly associated with ODD and CU for children with a methionine allele of the brain-derived neurotrophic factor gene. CU behaviors were uniquely predicted by harsh–intrusive parenting in infancy, whereas ODD behaviors were predicted by harsh–intrusive parenting in both infancy and toddlerhood/preschool. The results are discussed from the perspective of the contributions of caregiving behaviors as contributing to distinct aspects of early onset disruptive behavior.

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