Impaired autoregulation of cerebral blood flow in long-term Type I (insulin-dependent) diabetic patients with nephropathy and retinopathy

2008 ◽  
Vol 6 (6) ◽  
pp. 549-559 ◽  
Author(s):  
J. Kastrup ◽  
S. Rørsgaard ◽  
H.-H. Parving ◽  
N. A. Lassen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Diabetic Patients ◽  
Type I ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Term Type

Decreased distensibility of resistance vessels of the skin in type 1 (insulin-dependent) diabetic patients with microangiopathy

1987 ◽  
Vol 72 (1) ◽  
pp. 123-130 ◽  
Author(s):  
J. Kastrup ◽  
T. Nørgaard ◽  
H.-H. Parving ◽  
N. A. Lassen
Keyword(s):  
Blood Flow ◽  
Inverse Correlation ◽  
Diabetic Patients ◽  
Resistance Vessels ◽  
Head Up Tilt ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Type 1 Diabetic Patients ◽  
Term Type

1. The distensibility of the resistance vessels of the skin at the dorsum of the foot was determined in 11 long-term type 1 (insulin-dependent) diabetic patients with nephropathy and retinopathy, nine short-term type 1 diabetic patients without clinical microangiopathy and in nine healthy non-diabetic subjects. 2. Blood flow was measured by the local 133Xexenon washout technique in a vascular bed locally paralysed by the injection of histamine. Blood flow was measured before, during and after a 40 mmHg increase of the vascular transmural pressure, induced by head-up tilt. 3. The mean increase in blood flow during headup tilt was only 24% in diabetic subjects with and 48% in diabetic patients without clinical microangiopathy, compared with 79% in normal non-diabetic subjects (P < 0.0005 and P < 0.05, respectively). 4. An inverse correlation between microvascular distensibility and degree of hyalinosis of the terminal arterioles in biopsies from the skin was demonstrated (r = − 0.57, P < 0.001). 5. Our results suggest that terminal arteriolar hyalinosis reduces the microvascular distensibility and probably increases the minimal vascular resistance, thereby impeding hyperaemic responses.

Regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetic patients

1995 ◽  
Vol 16 (1) ◽  
pp. 10-16 ◽  
Author(s):  
B. KEYMEULEN ◽  
A. JACOBS ◽  
K. DE METZ ◽  
C. DE SADELEER ◽  
A. BOSSUYT ◽  
...  
Keyword(s):  
Cerebral Hypoperfusion ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Term Type

scholarly journals Cerebral blood flow increases during insulin-induced hypoglycaemia in Type 1 (insulin-dependent) diabetic patients and control subjects

Diabetologia ◽  
1987 ◽  
Vol 30 (5) ◽  
pp. 305-309 ◽  
Author(s):  
H. A. W. Neil ◽  
E. A. M. Gale ◽  
S. J. C. Hamilton ◽  
I. Lopez-Espinoza ◽  
R. Kaura ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Diabetic Patients ◽  
Control Subjects ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
And Control

Long-term treatment with simvastatin in hypercholesterolemic non-insulin-dependent diabetic patients

1992 ◽  
Vol 52 (2) ◽  
pp. 221-229 ◽  
Author(s):  
S. Zambon ◽  
A. Lapolla ◽  
G. Sartore ◽  
C. Gherardingher ◽  
A. Cortella ◽  
...  
Keyword(s):  
Term Treatment ◽  
Diabetic Patients ◽  
Long Term Treatment ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic
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