scholarly journals Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery

1996 ◽  
Vol 118 (5) ◽  
pp. 1147-1152 ◽  
Author(s):  
Peter M. Zygmunt ◽  
Gillian Edwards ◽  
Arthur H. Weston ◽  
S. Christopher Davis ◽  
Edward D. Högestätt
Keyword(s):  
Cytochrome P450 ◽  
Hepatic Artery ◽  
P450 Inhibitors

Chemical regulation of abscisic acid catabolism in plants by cytochrome P450 inhibitors

2005 ◽  
Vol 13 (14) ◽  
pp. 4491-4498 ◽  
Author(s):  
Nobutaka Kitahata ◽  
Shigeki Saito ◽  
Yutaka Miyazawa ◽  
Taishi Umezawa ◽  
Yukihisa Shimada ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Abscisic Acid ◽  
Chemical Regulation ◽  
P450 Inhibitors

Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage

2017 ◽  
Vol 46 (7) ◽  
pp. 2165-2173 ◽  
Author(s):  
Ana Zamora ◽  
Catherine A. Denning ◽  
David K. Heidary ◽  
Erin Wachter ◽  
Leona A. Nease ◽  
...  
Keyword(s):  
Dna Damage ◽  
Drug Resistance ◽  
Cytochrome P450 ◽  
Enzyme Inhibition ◽  
Metal Center ◽  
P450 Inhibitors

A light-activated prodrug delivers both a DNA damaging metal center and a cytochrome P450 inhibitor to prevent drug resistance.

Whole-cell amperometric biosensor for screening of cytochrome P450 inhibitors

2016 ◽  
Vol 223 ◽  
pp. 392-399 ◽  
Author(s):  
Tal Yoetz-Kopelman ◽  
Carmit Porat-Ophir ◽  
Yosi Shacham-Diamand ◽  
Amihay Freeman
Keyword(s):  
Cytochrome P450 ◽  
Amperometric Biosensor ◽  
Whole Cell ◽  
P450 Inhibitors

scholarly journals Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein

1996 ◽  
Vol 119 (4) ◽  
pp. 691-701 ◽  
Author(s):  
Gillian Edwards ◽  
Peter M. Zygmunt ◽  
Edward D. Högestätt ◽  
Arthur H. Weston
Keyword(s):  
Cytochrome P450 ◽  
Portal Vein ◽  
Potassium Currents ◽  
Mechanical Activity ◽  
Rat Portal Vein ◽  
P450 Inhibitors

scholarly journals Restarting antidepressant and antipsychotic medication after intentional overdoses: need for evidence-based guidance

2019 ◽  
Vol 9 ◽  
pp. 204512531983688
Author(s):  
Emma Tay ◽  
Andreas Sotiriou ◽  
Garry G. Graham ◽  
Kay Wilhelm ◽  
Leone Snowden ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Adverse Effects ◽  
Antipsychotic Drugs ◽  
Plasma Concentrations ◽  
Pharmacokinetic Data ◽  
Psychoactive Drugs ◽  
Cytochrome P450 Enzymes ◽  
Psychoactive Medication ◽  
Drug Overdoses ◽  
P450 Inhibitors

Intentional drug overdoses with antidepressant and antipsychotic medications are an increasingly common problem. Currently, there is little guidance with regard to reintroduction of these medications after intentional overdoses. We have used published toxicological and pharmacokinetic data to obtain factors which control the recovery from overdoses. From such data, we have proposed guidance regarding their reintroduction, provided there are no adverse effects or contraindications. Tentatively, we suggest that when adverse effects from the overdose are lost, treatment could recommence after a further mean half-life of elimination. Most antidepressant and antipsychotic drugs are metabolized by cytochrome P450 enzymes and, where cytochrome P450 inhibitors are co-ingested, serial plasma concentrations should optimally be obtained in order to assess a suitable time for reintroduction of the psychoactive drugs. We hope the proposals presented will stimulate research and discussion that lead to better guidance for clinicians concerning reintroduction of psychoactive medication after intentional overdose.

σRecognition sites in brain and peripheral tissues Characterization and effects of cytochrome P450 inhibitors

1994 ◽  
Vol 47 (7) ◽  
pp. 1231-1239 ◽  
Author(s):  
Diane L. DeHaven-Hudkins ◽  
Lorraine F. Lanyon ◽  
Felicia Y. Ford-Rice ◽  
Mark A. Ator
Keyword(s):  
Cytochrome P450 ◽  
Peripheral Tissues ◽  
P450 Inhibitors

1,2,3-Thiadiazole:  A Novel Heterocyclic Heme Ligand for the Design of Cytochrome P450 Inhibitors†

Biochemistry ◽  
1997 ◽  
Vol 36 (23) ◽  
pp. 7209-7216 ◽  
Author(s):  
Boga Ramesh Babu ◽  
Alfin D. N. Vaz
Keyword(s):  
Cytochrome P450 ◽  
P450 Inhibitors
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