Whole-cell amperometric biosensor for screening of cytochrome P450 inhibitors

2016 ◽  
Vol 223 ◽  
pp. 392-399 ◽  
Author(s):  
Tal Yoetz-Kopelman ◽  
Carmit Porat-Ophir ◽  
Yosi Shacham-Diamand ◽  
Amihay Freeman
Keyword(s):  
Cytochrome P450 ◽  
Amperometric Biosensor ◽  
Whole Cell ◽  
P450 Inhibitors

scholarly journals Characterization of P450 FcpC, the Enzyme Responsible for Bioconversion of Diosgenone to Isonuatigenone in Streptomyces virginiae IBL-14

2009 ◽  
Vol 75 (12) ◽  
pp. 4202-4205 ◽  
Author(s):  
Wei Wang ◽  
Feng-Qing Wang ◽  
Dong-Zhi Wei
Keyword(s):  
Escherichia Coli ◽  
Electron Transfer ◽  
Cytochrome P450 ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Whole Cell ◽  
Electron Transfer Chain ◽  
Streptomyces Virginiae ◽  
Transfer Chain

ABSTRACT A new cytochrome P450 monooxygenase, FcpC, from Streptomyces virginiae IBL-14 has been identified. This enzyme is found to be responsible for the bioconversion of a pyrano-spiro steroid (diosgenone) to a rare nuatigenin-type spiro steroid (isonuatigenone), which is a novel C-25-hydroxylated diosgenone derivative. A whole-cell P450 system was developed for the production of isonuatigenone via the expression of the complete three-component electron transfer chain in an Escherichia coli strain.

Chemical regulation of abscisic acid catabolism in plants by cytochrome P450 inhibitors

2005 ◽  
Vol 13 (14) ◽  
pp. 4491-4498 ◽  
Author(s):  
Nobutaka Kitahata ◽  
Shigeki Saito ◽  
Yutaka Miyazawa ◽  
Taishi Umezawa ◽  
Yukihisa Shimada ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Abscisic Acid ◽  
Chemical Regulation ◽  
P450 Inhibitors

Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage

2017 ◽  
Vol 46 (7) ◽  
pp. 2165-2173 ◽  
Author(s):  
Ana Zamora ◽  
Catherine A. Denning ◽  
David K. Heidary ◽  
Erin Wachter ◽  
Leona A. Nease ◽  
...  
Keyword(s):  
Dna Damage ◽  
Drug Resistance ◽  
Cytochrome P450 ◽  
Enzyme Inhibition ◽  
Metal Center ◽  
P450 Inhibitors

A light-activated prodrug delivers both a DNA damaging metal center and a cytochrome P450 inhibitor to prevent drug resistance.

scholarly journals Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery

1996 ◽  
Vol 118 (5) ◽  
pp. 1147-1152 ◽  
Author(s):  
Peter M. Zygmunt ◽  
Gillian Edwards ◽  
Arthur H. Weston ◽  
S. Christopher Davis ◽  
Edward D. Högestätt
Keyword(s):  
Cytochrome P450 ◽  
Hepatic Artery ◽  
P450 Inhibitors

scholarly journals Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein

1996 ◽  
Vol 119 (4) ◽  
pp. 691-701 ◽  
Author(s):  
Gillian Edwards ◽  
Peter M. Zygmunt ◽  
Edward D. Högestätt ◽  
Arthur H. Weston
Keyword(s):  
Cytochrome P450 ◽  
Portal Vein ◽  
Potassium Currents ◽  
Mechanical Activity ◽  
Rat Portal Vein ◽  
P450 Inhibitors
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