Etiopathogenic role of HLA-B27 alleles in ankylosing spondylitis

2005 ◽  
Vol 8 (3) ◽  
pp. 146-153 ◽  
Author(s):  
Nurullah AKKOC ◽  
Muhammad Asim KHAN
Keyword(s):  
Ankylosing Spondylitis ◽  
Hla B27

Enteric Microorganisms in Rheumatoid Diseases: Causative Agents and Possible Mechanisms

1985 ◽  
Vol 48 (6) ◽  
pp. 538-545 ◽  
Author(s):  
DOUGLAS L. ARCHER
Keyword(s):  
Immune Response ◽  
Ankylosing Spondylitis ◽  
Molecular Mechanisms ◽  
Enteric Pathogens ◽  
Gastrointestinal Illness ◽  
Hla B27 ◽  
Causative Agents ◽  
Related Individuals ◽  
Rheumatoid Diseases

The role of foodborne enteric pathogens in the development of three seronegative spondarthropathies (ankylosing spondylitis, Reiter's disease and reactive arthritis) is discussed. Although the prevalence of the HLA-B27 antigen in blood-related individuals suggests a genetic predisposition to these diseases, exogenous environmental factors are also indicated. A clinical profile is given to clarify certain relationships of the seronegative arthropathies. Evidence of the involvement of enteric pathogens in the onset of these conditions following gastrointestinal illness is considered along with the interactions of general and molecular mechanisms of the disease processes and the immune response.

HLA-B27 in the Greek Cypriot population: Distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27—related diseases. The possible protective role of B*2707

2004 ◽  
Vol 65 (12) ◽  
pp. 1451-1454 ◽  
Author(s):  
Agathi Varnavidou-Nicolaidou ◽  
Katerina Karpasitou ◽  
Dora Georgiou ◽  
Galatia Stylianou ◽  
Avgousta Kokkofitou ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Population Distribution ◽  
Protective Role ◽  
Hla B27 ◽  
Greek Cypriot

scholarly journals Role of HLA-B27 in the pathogenesis of ankylosing spondylitis

2017 ◽  
Vol 15 (4) ◽  
pp. 1943-1951 ◽  
Author(s):  
Bin Chen ◽  
Jia Li ◽  
Chongru He ◽  
Dahe Li ◽  
Wenwen Tong ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Hla B27

scholarly journals A review of the pathogenesis of ankylosing spondylitis

2008 ◽  
Vol 24 (1) ◽  
pp. E2 ◽  
Author(s):  
Elias Dakwar ◽  
Jaypal Reddy ◽  
Fernando L. Vale ◽  
Juan S. Uribe
Keyword(s):  
Ankylosing Spondylitis ◽  
Strong Association ◽  
Critical Role ◽  
Axial Skeleton ◽  
Causative Role ◽  
Hla B27 ◽  
Pathogenic Role ◽  
The Past ◽  
New Findings

✓ Ankylosing spondylitis (AS) is a chronic, progressive inflammatory rheumatic disease involving primarily the sacroiliac joints and the axial skeleton. The main clinical features are back pain and progressive stiffness of the spine. Oligoarthritis of the hips and shoulders, enthesopathy, and anterior uveitis are common, and involvement of the heart and lungs is rare. The current understanding of the pathogenesis of this disorder is limited. Despite the strong association between human leukocyte antigen B27 (HLA-B27) and susceptibility to AS reported over the past 30 years, the exact pathogenic role of HLA-B27 in AS and other spondyloarthropathies has yet to be determined. The authors present a review of the literature pertaining to the pathogenesis of AS over the past several decades. Ankylosing spondylitis is a polygenic disorder, with HLA-B27 playing a critical causative role in its pathogenesis. Animal studies of the immunobiology of HLA-B27 have provided significant insight into the pathogenic role of HLA-B27. The search for the antigenic peptide to support the “arthritogenic peptide” hypothesis has been disappointing. Over the past decade there has been increasing interest in the critical role of the misfolding and unfolded protein response of the heavy chain HLA-B27 in the modulation of the inflammatory response. Although there have been significant new findings in the understanding of the pathogenesis of AS, the exact mechanisms have yet to be identified. There is considerable optimism that additional susceptibility genes, predisposing factors, and regulators of the inflammatory process will be identified that will provide avenues for future treatment.

scholarly journals Do KIR genes impact the susceptibility to ankylosing spondylitis in Polish patients?

2019 ◽  
Vol 73 ◽  
pp. 310-315
Author(s):  
Edyta Majorczyk ◽  
Aleksandra Zoń-Giebel ◽  
Arkadiusz Chlebicki ◽  
Izabela Nowak ◽  
Piotr Wiland ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Inflammatory Arthritis ◽  
Gene Frequency ◽  
Killer Cell ◽  
Hla B27 ◽  
Chronic Inflammatory Arthritis ◽  
Kir Genes ◽  
Genes Encoding ◽  
Kir Gene

Aim: Ankylosing spondylitis (AS), a chronic inflammatory arthritis, is strongly associated with HLA-B27 gene worldwide. Among immunocyte receptors reacting with HLA-B27 are killer cell immunoglobulin-like receptors (KIRs ), particularly KIR3DL1 and KIR3DL2. The KIR family includes both activating and inhibitory receptors. These may be expressed on NK cells and subtypes of T cells, which via activating/inhibitory signals regulate the activity of immunocompetent cells and potentially have an impact on inflammation and autoimmunity occurrence. However, reports on the role of KIRs in AS are controversial. Material/Methods: We examined the possible associations of KIR genes in 192 patients diagnosed with AS compared with 191 control individuals. KIR genes were typed using PCR-SSP method. Results: No single KIR gene frequency was found to differ between patients and controls. Nevertheless, the genotypes containing three genes encoding activating KIRs, as well as those characterized by ratios of activating to inhibitory KIRs close to 1:2 (0.5–0.6) were significantly less frequent in AS than in controls. On the contrary, higher ratios (0.67–1.67) were more frequent in AS in comparison to controls. Conclusions: Our results suggest a protective effect of the presence of 3 (but not more) genes encoding activating KIRs, and of a ratio of activating to inhibitory KIRs close to 1:2 (0.5–0.6) but not higher. On the other hand, higher activating to inhibitory KIR ratios seem to predispose to AS. This suggests a very narrow window for optimal ratio of activating to inhibitory KIRs.

Prologue: 2009 Joint Meeting of Spondyloarthritis Research and Therapy Network (SPARTAN) and International Genetics of Ankylosing Spondylitis (IGAS)

2010 ◽  
Vol 37 (12) ◽  
pp. 2604-2605 ◽  
Author(s):  
JOHN D. REVEILLE ◽  
DANIEL O. CLEGG
Keyword(s):  
Ankylosing Spondylitis ◽  
Joint Meeting ◽  
Hla B27 ◽  
International Meeting ◽  
Collaborative Groups ◽  
The World ◽  
Working Together ◽  
Pan American ◽  
Physician Scientists

In July 2009, a 3-day conference was held in Houston, Texas, USA, by members of several groups: the Spondyloarthritis Research and Therapy Network (SPARTAN); the International Genetics of Ankylosing Spondylitis (IGAS); and interested members of the Pan American League of Associations of Rheumatology (PANLAR). The purpose of this meeting was to bring together physician scientists, clinicians, and educators from around the world who are working together to improve their understanding of spondyloarthritis (SpA). In addition to the annual educational and Fellows sessions for SPARTAN members, the conference included a one-day international meeting dedicated to the role of HLA-B27, along with a series of sessions that summarized advances among various collaborative groups and defined opportunities for future genetic initiatives. This supplement provides a review of the SPARTAN and IGAS meetings.

scholarly journals The role of HLA-B27 molecules in the pathogenesis of ankylosing spondylitis

Reumatismo ◽  
2011 ◽  
Vol 54 (3) ◽  
Author(s):  
A. Cauli ◽  
G. Dessole ◽  
P.P. Nurchis ◽  
A. Vacca ◽  
A. Mameli ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Hla B27
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