Role of Chronic Infection and Inflammation in the Gastrointestinal Tract in the Etiology and Pathogenesis of Idiopathic Parkinsonism. Part 3: Predicted Probability and Gradients of Severity of Idiopathic Parkinsonism Based on H. pylori Antibody Profile

Helicobacter ◽  
2005 ◽  
Vol 10 (4) ◽  
pp. 288-297 ◽  
Author(s):  
Clive Weller ◽  
Andre Charlett ◽  
Norman L. Oxlade ◽  
Sylvia M. Dobbs ◽  
R. John Dobbs ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Chronic Infection ◽  
Predicted Probability ◽  
Infection And Inflammation ◽  
Idiopathic Parkinsonism ◽  
Antibody Profile ◽  
H Pylori

scholarly journals Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer

2021 ◽  
Author(s):  
Olga Sokolova ◽  
Michael Naumann
Keyword(s):  
Gastric Cancer ◽  
Chronic Infection ◽  
Cellular Response ◽  
Molecular Signaling ◽  
Cellular Processes ◽  
Gastric Metaplasia ◽  
Infection And Inflammation ◽  
H Pylori ◽  
Substrate Proteins

AbstractInfection with H. pylori induces a strong host cellular response represented by induction of a set of molecular signaling pathways, expression of proinflammatory cytokines and changes in proliferation. Chronic infection and inflammation accompanied by secretory dysfunction can result in the development of gastric metaplasia and gastric cancer. Currently, it has been determined that the regulation of many cellular processes involves ubiquitinylation of molecular effectors. The binding of ubiquitin allows the substrate to undergo a change in function, to interact within multimolecular signaling complexes and/or to be degraded. Dysregulation of the ubiquitinylation machinery contributes to several pathologies, including cancer. It is not understood in detail how H. pylori impacts the ubiquitinylation of host substrate proteins. The aim of this review is to summarize the existing literature in this field, with an emphasis on the role of E3 ubiquitin ligases in host cell homeodynamics, gastric pathophysiology and gastric cancer.

scholarly journals Role of inflammation in gastrointestinal tract in aetiology and pathogenesis of idiopathic parkinsonism

2005 ◽  
Vol 44 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Clive Weller ◽  
Norman Oxlade ◽  
Sylvia M. Dobbs ◽  
R. John Dobbs ◽  
André Charlett ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Idiopathic Parkinsonism

PRE CANCER LESION H. pylori CHRONIC INFECTION

2000 ◽  
Vol 15 (12) ◽  
pp. H29-H29
Author(s):  
Vera D. Yoewono ◽  
E. Krinuhoni ◽  
W Marwoto ◽  
S.O. Sri Widodo
Keyword(s):  
Chronic Infection ◽  
H Pylori ◽  
Cancer Lesion
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