Adverse outcomes following convulsive status epilepticus in children: Relationship with hippocampal injury

Abstract Purpose: To study the risk factors and prognosis of malnutrition in patients with refractory convulsive status epilepticus. Methods: A total of 73 patients with refractory convulsive epileptic status in West China Hospital from January 2017 to May 2019 were collected. All patients met the 2016 International Anti-epileptic Alliance diagnostic criteria for refractory convulsive status epilepticus. A logistic regression model was used to evaluate the risk factors of malnutrition in refractory convulsive status epilepticus. Results: Of the 73 patients with refractory convulsive status epilepticus, 33 (45.21%) suffered from malnutrition during hospitalization, and hospitalization days (OR =1.251; 95% CI: 1.067-1.384; P =0.007), nasal feeding (OR =22.623; 95% CI: 1.091-286.899; P =0.013), and malnutrition on admission (OR =30.760; 95% CI: 1.064-89.797; P =0.046) were risk factors for malnutrition in patients with refractory convulsive status epilepticus. Conclusion: Malnutrition is a common complication during hospitalization in patients with refractory convulsive status epilepticus. Hospitalization days, nasal feeding, and malnutrition at admission are risk factors for malnutrition in patients with refractory convulsive status epilepticus. Further longitudinal studies are needed to identify the relationship between refractory convulsive status epilepticus and adverse outcomes.

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Long-term prognosis and predictors of outcomes after childhood convulsive status epilepticus

Karnataka Pediatric Journal ◽

10.25259/kpj_39_2020 ◽

2021 ◽

Vol 36 ◽

pp. 13-18

Author(s):

Snehal Surana ◽

Suresh Pujar

Keyword(s):

Status Epilepticus ◽

Febrile Seizures ◽

Adverse Outcomes ◽

Mesial Temporal Sclerosis ◽

Convulsive Status Epilepticus ◽

Normal Children ◽

Mortality And Morbidity ◽

Primary Determinant ◽

Long Term Prognosis

Objective: Childhood convulsive status epilepticus (CSE) is widely known to be associated with short-term and long-term mortality and morbidity, but the role of CSE itself on adverse outcomes is debatable. The additional effect of CSE characteristics on outcomes after CSE and whether prolonged seizures cause any long-term hippocampal injury which leads to developmental or memory impairment is uncertain. This review provides an overview of long-term prognosis after childhood CSE, highlighting data from recent literature. Findings: In previously normal children, the long-term prognosis after childhood CSE is favorable, with low incidence of epilepsy, motor, and cognitive difficulties. Mesial temporal sclerosis is uncommon in children after prolonged febrile seizures. In children with symptomatic causes and those with pre-existing neurological abnormalities, there is substantial morbidity after childhood CSE. Etiology is the primary determinant of outcome after childhood CSE and the additional effect of CSE characteristics such as seizure duration seems to be less than previously believed.

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Determinants of nutritional status and outcome in adults with RCSE: a retrospective cohort study

BMC Neurology ◽

10.1186/s12883-021-02373-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zhang Yu ◽

Liu Ling

Keyword(s):

Status Epilepticus ◽

Adverse Outcomes ◽

Convulsive Status Epilepticus ◽

Common Complication ◽

West China Hospital ◽

West China ◽

Nutritional Characteristics ◽

Duration Of Hospitalization ◽

The Relationship ◽

International League

Abstract Background This study aimed to investigate the association between nutritional characteristics in patients with refractory convulsive status epilepticus. Methods We retrospectively enrolled 73 patients with refractory convulsive status epilepticus over 18 years of age at the West China Hospital between January 2017 and May 2019. All patients met the 2016 International League Against Epilepsy diagnostic criteria for refractory convulsive status epilepticus. A logistic regression model was used to evaluate the association between malnutrition and refractory convulsive status epilepticus. Results Of the 73 patients with refractory convulsive status epilepticus, 33 (45.21 %) suffered from malnutrition during hospitalization, and duration of hospitalization in days (OR = 1.251; 95 % CI,–1.067–1.384; P = 0.007), nasal feeding (OR = 22.623; 95 % CI: 1.091-286.899; P = 0.013), and malnutrition on admission (OR = 30.760; 95 % CI: 1.064–89.797; P = 0.046) were significantly associated with malnutrition in patients with refractory convulsive status epilepticus. Conclusions Malnutrition is a common complication during hospitalization in patients with refractory convulsive status epilepticus. The duration of hospitalization (days), nasal feeding, and malnutrition at admission are associated with malnutrition in patients with refractory convulsive status epilepticus. Further longitudinal studies are needed to identify the relationship between refractory convulsive status epilepticus and adverse outcomes.

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Faculty Opinions recommendation of Treatment gap for convulsive status epilepticus in resource-poor countries.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733939146.793551336 ◽

2018 ◽

Author(s):

Richard FM Chin

Keyword(s):

Status Epilepticus ◽

Convulsive Status Epilepticus ◽

Treatment Gap ◽

Poor Countries ◽

Resource Poor

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G171(P) Aetiological profile and immediate outcome predictors of paediatric convulsive status epilepticus: an indian perspective

10.1136/archdischild-2019-rcpch.166 ◽

2019 ◽

Author(s):

R Shriyan ◽

KC Aggarwal ◽

R Gupta

Keyword(s):

Status Epilepticus ◽

Convulsive Status Epilepticus ◽

Outcome Predictors ◽

Indian Perspective

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Continuous EEG monitoring in the follow-up of convulsive status epilepticus patients: A proposal and preliminary validation of an EEG-based seizure build-up score (EaSiBUSSEs)

Neurophysiologie Clinique ◽

10.1016/j.neucli.2021.01.006 ◽

2021 ◽

Author(s):

Aurélie Hanin ◽

Sophie Demeret ◽

Vi-Huong Nguyen-Michel ◽

Virginie Lambrecq ◽

Vincent Navarro

Keyword(s):

Status Epilepticus ◽

Convulsive Status Epilepticus ◽

Eeg Monitoring ◽

Preliminary Validation ◽

Continuous Eeg ◽

Continuous Eeg Monitoring

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Emergency management of the paediatric patient with convulsive status epilepticus

Paediatrics & Child Health ◽

10.1093/pch/pxaa127 ◽

2021 ◽

Vol 26 (1) ◽

pp. 50-57

Author(s):

Kyle C McKenzie ◽

Cecil D Hahn ◽

Jeremy N Friedman

Keyword(s):

Clinical Practice ◽

Status Epilepticus ◽

Emergency Management ◽

Treatment Algorithm ◽

Position Statement ◽

Convulsive Status Epilepticus ◽

Pharmacological Management ◽

The Past ◽

New Treatment ◽

New Evidence

Abstract This guideline addresses the emergency management of convulsive status epilepticus (CSE) in children and infants older than 1 month of age. It replaces a previous position statement from 2011, and includes a new treatment algorithm and table of recommended medications based on new evidence and reflecting the evolution of clinical practice over the past several years. This statement emphasizes the importance of timely pharmacological management of CSE, and includes some guidance for diagnostic approach and supportive care.

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Salzburg Criteria, A Useful Tool in Non-Convulsive Status Epilepticus Diagnosis: A Retrospective Study

Clinical EEG and Neuroscience ◽

10.1177/1550059421991710 ◽

2021 ◽

pp. 155005942199171

Author(s):

Adriana Gómez Domínguez ◽

Raidili C. Mateo Montero ◽

Alba Díaz Cid ◽

Antonio J. P. Mazarro ◽

Ignacio R. Bailly-Bailliere ◽

...

Keyword(s):

Retrospective Study ◽

Status Epilepticus ◽

Prospective Studies ◽

Correct Diagnosis ◽

Original Description ◽

Neurological Deficits ◽

Convulsive Status Epilepticus ◽

Poor Outcome

Introduction. Non-convulsive status epilepticus (NCSE) has been traditionally a challenging electroencephalographic (EEG) diagnosis. For this reason, Salzburg consensus criteria (SCC) have been proposed to facilitate correct diagnosis. Methods. We retrospectively reanalyzed 41 cases referred to our department (from 2016 to 2018) under the suspicion of NCSE. In this study, we compared the original description (standard criteria) versus the updated description (SCC) of the same EEG. Results. Originally, 15 patients were diagnosed as NCSE (37%) and 26 patients as no NCSE (63%), using the standard criteria. Then, we analyzed EEGs according to the SCC, which led to the following results: 9 patients fulfilled the criteria for definite NCSE (22%), 20 patients were diagnosed as possible NCSE (49%) and 12 patients were diagnosed as no NCSE (29%). Subsequently, when we analyze the outcome of possible NCSE cases, we note that 50% of these patients presented mild-poor outcome (neurological deficits, deceased). Indeed, we observed worse outcomes in patients previously diagnosed as no NCSE and untreated, specifically post-anoxic cases. Conclusions. Salzburg criteria seem to be a useful tool to support NCSE diagnosis, introducing the category of possible NCSE. In our study, we observed that it contributes to improving the prognosis and management of the patients. However, more prospective studies are needed to demonstrate the accuracy of SCC.

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