scholarly journals Determinants of nutritional status and outcome in adults with RCSE: a retrospective cohort study

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhang Yu ◽  
Liu Ling
Keyword(s):  
Status Epilepticus ◽  
Adverse Outcomes ◽  
Convulsive Status Epilepticus ◽  
Common Complication ◽  
West China Hospital ◽  
West China ◽  
Nutritional Characteristics ◽  
Duration Of Hospitalization ◽  
The Relationship ◽  
International League

Abstract Background This study aimed to investigate the association between nutritional characteristics in patients with refractory convulsive status epilepticus. Methods We retrospectively enrolled 73 patients with refractory convulsive status epilepticus over 18 years of age at the West China Hospital between January 2017 and May 2019. All patients met the 2016 International League Against Epilepsy diagnostic criteria for refractory convulsive status epilepticus. A logistic regression model was used to evaluate the association between malnutrition and refractory convulsive status epilepticus. Results Of the 73 patients with refractory convulsive status epilepticus, 33 (45.21 %) suffered from malnutrition during hospitalization, and duration of hospitalization in days (OR = 1.251; 95 % CI,–1.067–1.384; P = 0.007), nasal feeding (OR = 22.623; 95 % CI: 1.091-286.899; P = 0.013), and malnutrition on admission (OR = 30.760; 95 % CI: 1.064–89.797; P = 0.046) were significantly associated with malnutrition in patients with refractory convulsive status epilepticus. Conclusions Malnutrition is a common complication during hospitalization in patients with refractory convulsive status epilepticus. The duration of hospitalization (days), nasal feeding, and malnutrition at admission are associated with malnutrition in patients with refractory convulsive status epilepticus. Further longitudinal studies are needed to identify the relationship between refractory convulsive status epilepticus and adverse outcomes.

scholarly journals Risk factors for malnutrition in refractory convulsive status epilepticus

2020 ◽  
Author(s):  
Yu Zhang ◽  
Deng Chen ◽  
Li-na Zhu ◽  
ling liu
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Status Epilepticus ◽  
Logistic Regression Model ◽  
Adverse Outcomes ◽  
Convulsive Status Epilepticus ◽  
Common Complication ◽  
West China Hospital ◽  
West China ◽  
The Relationship

Abstract Purpose: To study the risk factors and prognosis of malnutrition in patients with refractory convulsive status epilepticus. Methods: A total of 73 patients with refractory convulsive epileptic status in West China Hospital from January 2017 to May 2019 were collected. All patients met the 2016 International Anti-epileptic Alliance diagnostic criteria for refractory convulsive status epilepticus. A logistic regression model was used to evaluate the risk factors of malnutrition in refractory convulsive status epilepticus. Results: Of the 73 patients with refractory convulsive status epilepticus, 33 (45.21%) suffered from malnutrition during hospitalization, and hospitalization days (OR =1.251; 95% CI: 1.067-1.384; P =0.007), nasal feeding (OR =22.623; 95% CI: 1.091-286.899; P =0.013), and malnutrition on admission (OR =30.760; 95% CI: 1.064-89.797; P =0.046) were risk factors for malnutrition in patients with refractory convulsive status epilepticus. Conclusion: Malnutrition is a common complication during hospitalization in patients with refractory convulsive status epilepticus. Hospitalization days, nasal feeding, and malnutrition at admission are risk factors for malnutrition in patients with refractory convulsive status epilepticus. Further longitudinal studies are needed to identify the relationship between refractory convulsive status epilepticus and adverse outcomes.

scholarly journals Updated Cutoff Values of Basal Serum Calcitonin to Discriminate True Medullary Thyroid Cancer from Other Conditions of Hypercalcitoninemia

2021 ◽  
Author(s):  
Qianhui Liu ◽  
Xin Nie ◽  
Yong He ◽  
Guixing Li
Keyword(s):  
Thyroid Carcinoma ◽  
Disease Burden ◽  
Chronic Renal Disease ◽  
Tumor Diameter ◽  
Serum Calcitonin ◽  
West China Hospital ◽  
West China ◽  
Medullary Thyroid ◽  
Cutoff Values ◽  
The Relationship

Abstract Background Calcitonin (Ctn) is a tumor marker of medullary thyroid carcinoma (MTC). However, serum Ctn cutoff values for MTC diagnosis are still under discussion. This study aimed to identify the cutoff values of Ctn and explore the relationship between two tumor markers (Ctn and carcinoembryonic antigen (CEA)) and disease burden. Methods This was a retrospective study conducted in West China Hospital of Sichuan University. We included 61 MTC patients and 235 non-MTC patients with nonspecific elevation of Ctn (> 9.52 pg/mL for males and > 6.40 pg/mL for females) and collected patients’ demographic information, essential serological indicators, cervical ultrasound and pathological reports. Results Unlike MTC, papillary thyroid carcinoma (40.85%), uremia (18.73%), chronic renal disease (10.21%) and inflammation (8.94%) commonly occurred with hypercalcitoninemia. The Ctn cutoff values were 38.24 pg/mL for males and 26.00 pg/mL for females. The Ctn level was found to be positively related to the largest tumor diameter (r = 0.702). Serum Ctn levels were significantly higher in patients with lymph node metastasis than in those without (P < 0.05), but CEA levels did not differ (P > 0.05). Conclusion The best Ctn cutoff values for Chinese people to discriminate MTC from other hypercalcitoninemia conditions are 38.24 pg/mL for males and 26.00 pg/mL for females.

scholarly journals The Intrinsic Differences Between Immune Checkpoint Inhibitor Induced Myocarditis: A Retrospective Analysis of Real-World Data

2022 ◽  
Author(s):  
Yanna Lei ◽  
Xiufeng Zheng ◽  
Qian Huang ◽  
Xiaoying Li ◽  
Meng Qiu ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Medical Records ◽  
Immune Checkpoint Inhibitor ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Real World Data ◽  
West China Hospital ◽  
West China ◽  
Life Threatening ◽  
The Relationship

Abstract Immune-related myocarditis is a severe and even life-threatening immune-related adverse event (irAE) which may also be under-estimated due to the challenge in diagnosis. There have been few reports about the intrinsic difference between patients with immune-associated myocarditis. A retrospective analysis was conducted between March 2019 to June 2020 in West China Hospital and 18 patients with immune-related myocarditis were studied. Cases were classified as mild (n=12) or severe myocarditis (n=6) according to the clinical manifestations and haemodynamic complications. Covariates extracted from medical records were compared in different groups, and factors associated with severe myocarditis were identified. In this retrospective analysis, the median age of the 18 patients was 60 years old. Most cases occur early and approximately after the first or second ICI infusion. The severity of myocarditis may be correlated with lactate dehydrogenase (LDH) (P=0.04) and troponin (P=0.0057). The relationship between troponin and myocarditis was further confirmed in another cohort which including 30 patients. In addition, patients are more likely to develop multi-irAEs, and myositis was the most common second irAE. Those who experience multi-irAEs had significantly higher LDH (P=0.02) as well as myoglobin levels (P=0.02) than did not experience. All patients were treated with steroids timely and the mortality rate was 5.6% in our study. In this study, we explore risk factors for severe myocarditis and we emphasized the importance of a multidisciplinary team in assisting diagnosis and treatment options. It is critical to initiate corticosteroid therapy, regardless of the severity of the myocarditis.

scholarly journals Long-term prognosis and predictors of outcomes after childhood convulsive status epilepticus

2021 ◽  
Vol 36 ◽  
pp. 13-18
Author(s):  
Snehal Surana ◽  
Suresh Pujar
Keyword(s):  
Status Epilepticus ◽  
Febrile Seizures ◽  
Adverse Outcomes ◽  
Mesial Temporal Sclerosis ◽  
Convulsive Status Epilepticus ◽  
Normal Children ◽  
Mortality And Morbidity ◽  
Primary Determinant ◽  
Long Term Prognosis

Objective: Childhood convulsive status epilepticus (CSE) is widely known to be associated with short-term and long-term mortality and morbidity, but the role of CSE itself on adverse outcomes is debatable. The additional effect of CSE characteristics on outcomes after CSE and whether prolonged seizures cause any long-term hippocampal injury which leads to developmental or memory impairment is uncertain. This review provides an overview of long-term prognosis after childhood CSE, highlighting data from recent literature. Findings: In previously normal children, the long-term prognosis after childhood CSE is favorable, with low incidence of epilepsy, motor, and cognitive difficulties. Mesial temporal sclerosis is uncommon in children after prolonged febrile seizures. In children with symptomatic causes and those with pre-existing neurological abnormalities, there is substantial morbidity after childhood CSE. Etiology is the primary determinant of outcome after childhood CSE and the additional effect of CSE characteristics such as seizure duration seems to be less than previously believed.

scholarly journals Impact of co-morbidities on the mortality of patients with status epilepticus and the utility of RCBI score in evaluating the mortality of status epilepticus

2020 ◽  
Author(s):  
Yu Zhang ◽  
Deng Chen ◽  
Li-na Zhu ◽  
ling liu
Keyword(s):  
Status Epilepticus ◽  
Hospital Mortality ◽  
Roc Curve ◽  
Poor Prognosis ◽  
Influential Factors ◽  
Western China ◽  
Convulsive Status Epilepticus ◽  
Roc Curve Analysis ◽  
West China Hospital ◽  
Area Under Roc Curve

Abstract Background: To investigate the influential factors of complications on prognosis of patients with status epilepticus, modify the Complication Burden Index （CBI）into the Rankin CBI（RCBI）, and analyze its practicability in status epilepticus in western China. Method: A total of 396 patients with status epilepticus were studied from December 2016 to January 2019 in West China Hospital. The clinical data were collected, including demographic characteristics, status epilepticus characteristics. Statistical analysis was performed using SPSS 22.0 and MedCalc ROC，and logistic regression was used to analyze the influencing factors of hospitalization death and poor prognosis (GOS scale is 1-3). Results: Of the 396 patients with status epilepticus included in the study, 43 (10.9%) died in hospital and 114 (28.8%) had poor prognosis. Using ROC curve analysis, when RCBI > 3, the area under the ROC curve of hospitalization death was 0.914 , p < 0.0001; When RCBI > 3, the area under ROC curve for poor prognosis was 0.882, p < 0.0001. There were 327 people with convulsive status epilepticus, including 41 deaths. When RCBI>3, the area under the hospital mortality curve was 0.915 (p<0.0001). A total of 100 patients had a poor prognosis. When RCBI>3, the area under the poor prognosis curve was 0.867 (p<0.0001). Conclusions: The hospital mortality rate of patients with status epilepticus is 10.9%. RCBI >3 points had a certain significance for predicting hospitalization death and poor prognosis of status epilepticus. There were no significant differences in RCBI scales for convulsive status epilepticus and non-convulsive status epilepticus.

West China Hospital Back Pain Treatment Measures

2010 ◽  
Author(s):  
Ernest Volinn ◽  
Bangxiang Yang ◽  
Jing He ◽  
Xiaoming Sheng ◽  
Jian Ying ◽  
...  
Keyword(s):  
Back Pain ◽  
Pain Treatment ◽  
West China Hospital ◽  
West China ◽  
Treatment Measures

Organizational Justice enhances Subjective Well-being

2016 ◽  
Vol 3 (3) ◽  
Author(s):  
Ms. Anjali Sahai ◽  
Prof. (Dr). Abha Singh
Keyword(s):  
Organizational Justice ◽  
Satisfaction With Life ◽  
Interactional Justice ◽  
Well Being ◽  
Adverse Outcomes ◽  
Satisfaction With Life Scale ◽  
Subjective Well Being ◽  
Negative Experience ◽  
Life Scale ◽  
The Relationship

Organizational Justice has the potential to create major impact on organizations and employees alike. These include greater commitment, trust, enhanced job performance, more citizenship behaviors and less number of conflicts. It has been reported that employees seem to have a universal concern for Justice that transcends the self and that many are subject to biases at various point of time in their work life. Sometimes these biases lead to adverse outcomes including decreased level of subjective well-being. Subjective well-being is a broad category that includes life satisfaction, positive affect, and low negative affect, such as anger, sadness and fear. Thus to study the relationship between Organizational justice and subjective well-being, a sample of 88 employees working in Private Universities of NCR region were examined. For this purpose, the Organizational Justice scales consisting of Measure of Procedural & Interactional Justice and Distributive Justice Index scale by Moorman, Blakely & Niehoff (1998) and Subjective Wellbeing Scales inclusive of the Satisfaction with Life Scale(SWLS),Scale of Positive and Negative Experience(SPANE) and Flourishing Scale (FS) by Ed Diener (2004)were used. Results indicate significant relationship between the three types of Organizational justice and subjective well-being of employees.

Equity in Telemedicine for Older Adults During the Covid-19 Pandemic (Preprint)

2020 ◽  
Author(s):  
Weihong Kuang ◽  
Guojun Zeng ◽  
Yunbo Nie ◽  
Yan Cai ◽  
Jin Li ◽  
...  
Keyword(s):  
Older Adults ◽  
Paradigm Shift ◽  
Drug Prescription ◽  
Rapid Change ◽  
Policy Makers ◽  
West China Hospital ◽  
West China ◽  
Effective Strategies ◽  
Online Treatment ◽  
Treatment Disparities

UNSTRUCTURED The COVID-19 pandemic spurred unprecedented progress on a paradigm shift to telemedicine to limit exposure to the virus. Telemedicine has many benefits. In the West China Hospital of Sichuan University, we use it to do COVID-19 related tele-educations to health professionals and general population, tele-diagnosis, online treatment and internet-based drug prescription and delivery. However, at our practices, we are noticing that many older adults could not make appointment with doctors due to their difficulty using the internet-based platform. We worried that older adults who need healthcare the most are not well prepared for this rapid change. We need to pay attention to avoid causing treatment disparities for vulnerable older adults 60 years of age and over. Researchers and policy makers should work together to study effective strategies and make proper policies to mitigate barriers older adults face when using telemedicine.

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