Effect of Chronic Ethanol Consumption on Protective T-Helper 1 and T-Helper 2 Immune Responses Against the Parasites Leishmania major and Strongyloides stercoralis in Mice

2001 ◽  
Vol 25 (4) ◽  
pp. 571-578 ◽  
Author(s):  
Alejandro J. Krolewiecki ◽  
Shalom Leon ◽  
Phillip A. Scott ◽  
Thomas J. Nolan ◽  
Gerhard A. Schad ◽  
...  
Keyword(s):  
Immune Responses ◽  
Leishmania Major ◽  
Strongyloides Stercoralis ◽  
Ethanol Consumption ◽  
Chronic Ethanol ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Chronic Ethanol Consumption

T-HELPER-1 AND T-HELPER-2 IMMUNE RESPONSES IN MICE INFECTED WITH THE INTESTINAL FLUKE NEODIPLOSTOMUM SEOULENSE: THEIR POSSIBLE ROLES IN WORM EXPULSION AND HOST FATALITY

2007 ◽  
Vol 93 (5) ◽  
pp. 1036-1045 ◽  
Author(s):  
Eun-Hee Shin ◽  
Sang-Hyup Lee ◽  
Jae-Lip Kim ◽  
Yun-Kyu Park ◽  
Jong-Yil Chai
Keyword(s):  
Immune Responses ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Worm Expulsion

Chronic Ethanol Consumption Impairs Cellular Immune Responses Against HCV NS5 Protein Due to Dendritic Cell Dysfunction

2007 ◽  
Vol 132 (2) ◽  
pp. 698-708 ◽  
Author(s):  
Costica Aloman ◽  
Stephan Gehring ◽  
Philip Wintermeyer ◽  
Noriyoshi Kuzushita ◽  
Jack R. Wands
Keyword(s):  
Dendritic Cell ◽  
Immune Responses ◽  
Ethanol Consumption ◽  
Chronic Ethanol ◽  
Cell Dysfunction ◽  
Cellular Immune Responses ◽  
Chronic Ethanol Consumption ◽  
Cellular Immune

scholarly journals Induction of T helper 1- and T helper 2-type immune responses duringHaemonchus contortus infection in sheep

Immunology ◽  
2000 ◽  
Vol 99 (3) ◽  
pp. 458-463 ◽  
Author(s):  
H. S. Gill ◽  
K. Altmann ◽  
M. L. Cross ◽  
A. J. Husband
Keyword(s):  
Immune Responses ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2

scholarly journals High Levels of Susceptibility and T Helper 2 Response in MyD88-Deficient Mice Infected with Leishmania major Are Interleukin-4 Dependent

2003 ◽  
Vol 71 (12) ◽  
pp. 7215-7218 ◽  
Author(s):  
Andrea Debus ◽  
Joachim Gläsner ◽  
Martin Röllinghoff ◽  
André Gessner
Keyword(s):  
Knockout Mice ◽  
Leishmania Major ◽  
Parasite Burden ◽  
Interleukin 4 ◽  
Myeloid Differentiation ◽  
Interleukin 12 ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Deficient Mice

ABSTRACT Myeloid differentiation protein 88 (MyD88) is a general adaptor for the signaling cascade through receptors of the Toll/IL-1R family. When infected with Leishmania major parasites, MyD88-deficient mice displayed a dramatically enhanced parasite burden in their tissues similar to that found in susceptible BALB/c mice. In contrast, MyD88 knockout mice did not develop ulcerating lesions despite a lack of interleukin-12 (IL-12) production and a predominant T helper 2 cell response. Blockade of IL-4 produced early (day 1) after infection restored a protective T helper 1 response in MyD88 knockout mice.

scholarly journals Prenatal exposure to bisphenol A up-regulates immune responses, including T helper 1 and T helper 2 responses, in mice

Immunology ◽  
2004 ◽  
Vol 112 (3) ◽  
pp. 489-495 ◽  
Author(s):  
Shin Yoshino ◽  
Kouya Yamaki ◽  
Xiaojuan Li ◽  
Tao Sai ◽  
Rie Yanagisawa ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bisphenol A ◽  
Prenatal Exposure ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2

scholarly journals OX40L–OX40 Signaling in Atopic Dermatitis

2021 ◽  
Vol 10 (12) ◽  
pp. 2578
Author(s):  
Masutaka Furue ◽  
Mihoko Furue
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
Memory T Cells ◽  
Effector Memory ◽  
T Helper ◽  
T Helper 1 ◽  
Therapeutic Success ◽  
T Helper 2 ◽  
Promising Target ◽  
Antigen Presenting

OX40 is one of the co-stimulatory molecules expressed on T cells, and it is engaged by OX40L, primarily expressed on professional antigen-presenting cells such as dendritic cells. The OX40L–OX40 axis is involved in the sustained activation and expansion of effector T and effector memory T cells, but it is not active in naïve and resting memory T cells. Ligation of OX40 by OX40L accelerates both T helper 1 (Th1) and T helper 2 (Th2) effector cell differentiation. Recent therapeutic success in clinical trials highlights the importance of the OX40L–OX40 axis as a promising target for the treatment of atopic dermatitis.

Remission of Alopecia Universalis after 1 Year of Treatment with Dupilumab in a Patient with Severe Atopic Dermatitis

2021 ◽  
pp. 1-4
Author(s):  
Maurizio Romagnuolo ◽  
Mauro Barbareschi ◽  
Simona Tavecchio ◽  
Luisa Angileri ◽  
Silvia Mariel Ferrucci
Keyword(s):  
Atopic Dermatitis ◽  
Skin Disorder ◽  
Human Monoclonal Antibody ◽  
Severe Atopic Dermatitis ◽  
T Helper ◽  
T Helper 1 ◽  
Th2 Response ◽  
Alopecia Universalis ◽  
T Helper 2 ◽  
Relapsing Remitting

Alopecia areata (AA), an autoimmune disease with a relapsing-remitting course, represents the second cause of non­scarring alopecia worldwide and is associated with several comorbidities, notably atopic dermatitis (AD). In particular, AD is related to its more severe forms alopecia totalis (AT) and alopecia universalis (AU) [Nat Rev Dis Primers. 2017;3:17011]. Considering that AA has been classified as T helper 1-driven disease, whereas AD is the prototypical T helper 2 (Th2)-driven skin disorder, recent studies suggest that these forms may underlie a different chemokine expression resulting in a Th2 skewing as a key pathomechanism that could explain this association [JAMA Dermatol. 2015 May;151(5):522–8]. Several reports showed that dupilumab, a fully human monoclonal antibody targeting the interleukin 4α receptor and thus downregulating Th2 response, led to an improvement of AA associated with AD; most of these patients were females with AT or AU, early-onset AD, and atopic comorbidities [Exp Dermatol. 2020 Aug;29(8):726–32]. We report here a case to further support this hypothesis.

Sign in / Sign up

Export Citation Format

Share Document