Cost-effectiveness of prion filtration of red blood cells to reduce the risk of transfusion-transmitted variant Creutzfeldt-Jakob disease in the Republic of Ireland

Transfusion ◽  
2012 ◽  
Vol 52 (11) ◽  
pp. 2285-2293 ◽  
Author(s):  
Conor Teljeur ◽  
Martin Flattery ◽  
Patricia Harrington ◽  
Michelle O'Neill ◽  
Patrick S. Moran ◽  
...  
2020 ◽  
Vol 25 (5) ◽  
pp. 421-440
Author(s):  
Geraldine Shaw

Background The national clinical programmes (NCPs) were established in 2010 to achieve three objectives, namely: improve quality, access and cost effectiveness. Limited research exists on their implementation in the Republic of Ireland (ROI). This qualitative study identified key stakeholders’ perceptions on (a) implementation thus far, and (b) conditions perceived necessary for implementation in acute hospitals. Aims The overall aim of this research was to undertake an in-depth study to explore from the perspectives of key stakeholders, their perceptions on implementation of the national clinical programmes, thus far, in relation to three overarching objectives (to improve quality, access, cost effectiveness) and what are the conditions necessary for their implementation in the Republic of Ireland's acute hospitals. Methods Twenty participants were interviewed using face-to-face audio-recorded semi-structured interviews. Transcribed data were coded and analysed, and a number of themes emerged from the dataset relating to the study aims. Results Implementation was perceived as being inconsistent. Outcomes were identified as: best practice guidelines, models of care, protocols, pathways; education & training; new services; improved discharges; improved patient outcomes; reduced length of stay; timely access; reduced waiting lists; cost effectiveness and other intangible outcomes. Sixteen conditions, under four themes, were perceived necessary for implementation, namely: Governance – structure, audit & monitoring, senior management support, accountability, and clear objectives and expectations; Communication – visible face-to-face engagement, internal awareness, and external awareness; Leadership – programme level, national level, hospital level, and professional level; Resources – budget, staff, information technology, training, skills, and competency. Conclusions This study adds to the existing limited body of knowledge on implementation of the NCPs in the acute hospitals in the ROI while contributing to the wider international literature in this area. The study provides hitherto unreported knowledge on the conditions that are perceived necessary for implementation. Novel in the ROI context is the perceived necessity to condense the number of NCPs, placing greater emphasis on (a) the need to structurally integrate the NCPs across the continuum of care, and (b) the importance of communication through visible face-to-face engagement. This study concludes that significant progress has been made by the NCPs towards meeting the objectives, albeit to varying degrees. There is a strong perception that the NCPs should remain, and that addressing the conditions perceived necessary for implementation in the areas of governance, communications, leadership and resources by both top-down senior health officials and bottom-up front-line hospital staff would significantly enhance the ability of the NCPs to meet objectives and implementation. It provides the ROI health services with valuable information to inform future reform, strategic planning and NCP implementation.


2016 ◽  
Vol 18 (3) ◽  
pp. 321-335
Author(s):  
Paddy Gillespie ◽  
Edel Murphy ◽  
Susan M. Smith ◽  
Margaret E. Cupples ◽  
Molly Byrne ◽  
...  

2017 ◽  
Vol 187 (2) ◽  
pp. 515-520 ◽  
Author(s):  
F. M. Brett ◽  
S. Looby ◽  
A. Chalissery ◽  
D. Chen ◽  
C. Heaney ◽  
...  

Diabetologia ◽  
2015 ◽  
Vol 59 (3) ◽  
pp. 436-444 ◽  
Author(s):  
Andriy Danyliv ◽  
Paddy Gillespie ◽  
Ciaran O’Neill ◽  
Marie Tierney ◽  
Angela O’Dea ◽  
...  

Transfusion ◽  
2014 ◽  
Vol 54 (9) ◽  
pp. 2194-2201 ◽  
Author(s):  
Hong Yang ◽  
Luisa Gregori ◽  
David M. Asher ◽  
Jay S. Epstein ◽  
Steven A. Anderson

2003 ◽  
Vol 7 (2) ◽  
Author(s):  
A M Molesworth

The end of 2002 has seen a total of 129 definitive or probable cases of variant Creutzfeldt-Jakob disease (vCJD) reported in the United Kingdom (UK)[1]. Elsewhere numbers remain small, with 8 cases in Europe (6 in France, 1 in Italy, and 1 in the Republic of Ireland) and a further 2 cases in North America (Canada and the United States).


2015 ◽  
Vol 96 (3) ◽  
pp. 437-440
Author(s):  
V M Belopukhov ◽  
R G Turaev ◽  
E E Bel’skaya ◽  
R S Gadyl’shina ◽  
N S Gimatdinova

Aim. To study the peculiarities of AB0, Rh and Kell blood group distribution in donors of the Republic of Tatarstan in detail.Methods. Blood samples of 180 279 donors of blood components (erythrocytes, platelets, serum) donated form 2008 to 2014 both in hospital and mobile settings were analyzed. The material for the study was the blood donors of blood components (red blood cells, plasma and platelets) for the period 2008-2014, the city, donated blood, both in stationary and in exit conditions. Typing erythrocyte antigens for AB0, Rh and Kell systems was performed using «Scangel» gel technology by «Hemos SP II» and IH-1000 immunohematologic analyzers using the diagnostic card produced by «Bio-Rad laboratories», as well as by microtray method on «Galileo Neo» automated scanner, and on plate by anti-A, anti-B, anti-AB, anti-A1, anti-C, anti-Cw, anti-c, anti-D, anti-E anti-e and anti-Kell monoclonal reagents produced by «LLC Gematolog» (Moscow), LLC «Mediklon» (St. Petersburg), «ImuMed» (Germany). AB0 blood group was also determined by the cross method using own-produced AB0 standard isohemagglutinating sera and AB0 standard red blood cells. Rhesus blood group was also determined by own-produced universal a-D, a-DC reagent, used to identify Du gel cards produced by «Bio-Rad laboratories», «Grifols» were used for Du detection. Statistical analysis was performed and the data were obtained using the automated information system for Transfusions management, installed in the Republican Blood Centre in 2008.Results. Analysis of AB0 system blood groups distribution in the Republic of Tatarstan showed that blood group 0 (I) was the most common - 33.7%, 31.1% donors had A (II) blood group, 23.7% donors - B (III) group, 11.5% - AB0 (IV) group. Anti-A1 irregular agglutinin was found in 5 (0.57%) out of 878 donors with A2 (II) group, and in 53 (12.4%) of 428 A2B (IV) donors. The shares of Rh (D)-positive and Rh (D)-negative donors (87.4 and 12.6%, respectively), was revealed. Rh-positive donors included donors having antigen phenotypes C, E, and Du.Conclusion. Formation and completion of a serologically tested donor’s database in the Republic of Tatarstan is required to compile the gene geographic map of the region.


Author(s):  
Kosuke Ueda ◽  
Hiroto Washida ◽  
Nakazo Watari

IntroductionHemoglobin crystals in the red blood cells were electronmicroscopically reported by Fawcett in the cat myocardium. In the human, Lessin revealed crystal-containing cells in the periphral blood of hemoglobin C disease patients. We found the hemoglobin crystals and its agglutination in the erythrocytes in the renal cortex of the human renal lithiasis, and these patients had no hematological abnormalities or other diseases out of the renal lithiasis. Hemoglobin crystals in the human erythrocytes were confirmed to be the first case in the kidney.Material and MethodsTen cases of the human renal biopsies were performed on the operations of the seven pyelolithotomies and three ureterolithotomies. The each specimens were primarily fixed in cacodylate buffered 3. 0% glutaraldehyde and post fixed in osmic acid, dehydrated in graded concentrations of ethanol, and then embedded in Epon 812. Ultrathin sections, cut on LKB microtome, were doubly stained with uranyl acetate and lead citrate.


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