Statin use is associated with lower inflammation and erythropoietin responsiveness index in hemodialysis patients

Background/Aims: The objective of this study is to evaluate the relation between sclerostin, arterial stiffness, and cardiovascular events (CVE) in hemodialysis patients (HD). Methods: Sclerostin level and carotid-femoral pulse wave velocity (PWV) in 97 HD patients and sclerostin level in 40 controls were measured. Results: Sclerostin level was significantly higher in patients than in controls. Sclerostin associated positively with age, male gender, cardiovascular disease, statin use, BMI, and PWV while negatively with alkaline phosphatase, parathormone (PTH), Kt/V, cinacalcet and vitamin D use in univariable correlation analyses. Sclerostin associated positively with male gender and statin use but negatively with PTH in multivariate regression analyses. During observation, 30 fatal or nonfatal CVEs were observed. While univariate correlation analysis showed a positive association between PWV and sclerostin, there was no relation between the two in multivariate regression analysis. Conclusion: Further studies are needed to understand the role of sclerostin in predicting PWV changes in HD patients.

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Quantitative Assessment of HCV Load in Chronic Hemodialysis Patients

Infection Control and Hospital Epidemiology ◽

10.1017/s0195941700070004 ◽

1999 ◽

Vol 20 (02) ◽

pp. 123

Author(s):

Gina Pugliese ◽

Martin S. Favero

Keyword(s):

Quantitative Assessment ◽

Hemodialysis Patients ◽

Chronic Hemodialysis

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A cost effective decision analysis model comparing two strategies for maintaining hepalitis B immunity in hemodialysis patients

Gastroenterology ◽

10.1016/s0016-5085(01)82763-3 ◽

2001 ◽

Vol 120 (5) ◽

pp. A556-A556

Author(s):

S WESTON ◽

S SAAB ◽

D LY ◽

M BREZINA ◽

H YEE ◽

...

Keyword(s):

Decision Analysis ◽

Cost Effective ◽

Hemodialysis Patients ◽

Decision Analysis Model ◽

Analysis Model ◽

Effective Decision

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Statin Use Tied to Fewer Relapses in Prostate Ca

Internal Medicine News ◽

10.1016/s1097-8690(08)70273-7 ◽

2008 ◽

Vol 41 (5) ◽

pp. 35

Author(s):

JANE SALODOF MACNEIL

Keyword(s):

Statin Use

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Statin Use Linked to Reduced Incidence of RA

Internal Medicine News ◽

10.1016/s1097-8690(10)70026-3 ◽

2010 ◽

Vol 43 (1) ◽

pp. 28

Author(s):

MITCHEL L. ZOLER

Keyword(s):

Statin Use

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Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000604 ◽

2019 ◽

pp. 1-7

Author(s):

Hadeer Zakaria ◽

Tarek M. Mostafa ◽

Gamal A. El-Azab ◽

Nagy AH Sayed-Ahmed

Keyword(s):

Fatty Acids ◽

Vitamin E ◽

Fish Oil ◽

Wheat Germ ◽

Hemodialysis Patients ◽

Nutritional Indices ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Wheat Germ Oil ◽

Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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