Type III apparatus of Pseudomonas aeruginosa as a tool to diagnose pulmonary infection in cystic fibrosis patients

Apmis ◽  
2012 ◽  
Vol 120 (8) ◽  
pp. 622-627 ◽  
Author(s):  
Aline C. Cruz ◽  
Bianca C. Neves ◽  
Laurinda Y. S. Higa ◽  
Tânia Folescu ◽  
Elizabeth A. Marques ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Pulmonary Infection ◽  
Type Iii

scholarly journals EPS4.02 Porphyromonas, a candidate biomarker for detection of Pseudomonas aeruginosa pulmonary infection in cystic fibrosis

2018 ◽  
Vol 17 ◽  
pp. S43 ◽  
Author(s):  
C.-A. Guilloux ◽  
G. Marenne ◽  
S. Mondot ◽  
C. Lamoureux ◽  
L. Billard ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Pulmonary Infection

scholarly journals Pseudomonas aeruginosa bacteremia and prostatitis in a patient with cystic fibrosis

2013 ◽  
Vol 7 (1-2) ◽  
pp. 1
Author(s):  
Anju Anand ◽  
Elizabeth Tullis ◽  
Anne Stephenson ◽  
J. Curtis Nickel ◽  
Michael J. Leveridge
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Lower Urinary Tract ◽  
Pulmonary Infection ◽  
Respiratory Infections ◽  
Bacterial Prostatitis ◽  
Systemic Dissemination ◽  
Microbial Etiology ◽  
Acute Bacterial Prostatitis ◽  
Lower Urinary

Patients with cystic fibrosis (CF) commonly suffer chronic respiratory infections, although systemic dissemination is relatively rare. Acute bacterial prostatitis presents dramatically and is believed to be mostly caused by local migration (with or without instrumentation) of the lower urinary tract and presents with a predictable microbial etiology. We report a case of a 26-year-old man presenting with acute Pseudomonas aeruginosa bacterial prostatitis due to hematogenous propagation from a chronic pulmonary infection.

scholarly journals Expression of ExsA in trans Confers Type III Secretion System-Dependent Cytotoxicity on Noncytotoxic Pseudomonas aeruginosa Cystic Fibrosis Isolates

2001 ◽  
Vol 69 (1) ◽  
pp. 538-542 ◽  
Author(s):  
Denis Dacheux ◽  
Ina Attree ◽  
Bertrand Toussaint
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Transcriptional Activation ◽  
Type Iii Secretion ◽  
Ex Vivo ◽  
Type Iii Secretion System ◽  
Secretion System ◽  
Type Iii ◽  
In Trans

ABSTRACT Twelve Pseudomonas aeruginosa cystic fibrosis isolates that are not able to exert a type III secretion system (TTSS)-dependent cytotoxicity towards phagocytes have been further studied. The strains, although possessing TTSS genes and exsA, which encodes a positive regulator of the TTSS regulon, showed no transcriptional activation of the exsCBA regulatory operon. The expression of exsA in trans restored the in vitro secretion of TTSS proteins and ex vivo cytotoxicity.

scholarly journals Sera from Adult Patients with Cystic Fibrosis Contain Antibodies to Pseudomonas aeruginosa Type III Apparatus

2001 ◽  
Vol 69 (2) ◽  
pp. 1185-1188 ◽  
Author(s):  
Joel Moss ◽  
Mary E. Ehrmantraut ◽  
Bruce D. Banwart ◽  
Dara W. Frank ◽  
Joseph T. Barbieri
Keyword(s):  
Cystic Fibrosis ◽  
Immune Response ◽  
Pseudomonas Aeruginosa ◽  
Adult Patients ◽  
Eukaryotic Cells ◽  
Type Iii

ABSTRACT Expression of type III proteins of Pseudomonas aeruginosa in patients with cystic fibrosis (CF) was investigated by measuring the immune response against components of the type III pathway. Twenty-three of the 33 sera contained antibodies against PcrV, a protein involved in translocation of type III cytotoxins into eukaryotic cells, and 11 of 33 had antibodies against ExoS, while most CF sera contained antibodies against PopB and PopD, components of the type III apparatus. These data indicate that P. aeruginosacommonly expresses components of the type III translocation apparatus in adult CF patients.

scholarly journals 64 Chronic pulmonary infection with Pseudomonas aeruginosa in relation to F508del mutation in patients with cystic fibrosis

2016 ◽  
Vol 15 ◽  
pp. S67-S68
Author(s):  
S. Sciuca ◽  
L. Balanetchi ◽  
C. Grigore ◽  
O. Dimitrova ◽  
A. Cotoman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Pulmonary Infection

scholarly journals Alginate synthesis by Pseudomonas aeruginosa: a key pathogenic factor in chronic pulmonary infections of cystic fibrosis patients.

1991 ◽  
Vol 4 (2) ◽  
pp. 191-206 ◽  
Author(s):  
T B May ◽  
D Shinabarger ◽  
R Maharaj ◽  
J Kato ◽  
L Chu ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Biosynthetic Pathway ◽  
Pulmonary Infection ◽  
Regulatory Mechanism ◽  
Regulatory Proteins ◽  
Host Immune System ◽  
Pathogenic Factor ◽  
Pulmonary Infections

Pulmonary infection by mucoid, alginate-producing Pseudomonas aeruginosa is the leading cause of mortality among patients suffering from cystic fibrosis. Alginate-producing P. aeruginosa is uniquely associated with the environment of the cystic fibrosis-affected lung, where alginate is believed to increase resistance to both the host immune system and antibiotic therapy. Recent evidence indicates that P. aeruginosa is most resistant to antibiotics when the infecting cells are present as a biofilm, as they appear to be in the lungs of cystic fibrosis patients. Inhibition of the protective alginate barrier with nontoxic compounds targeted against alginate biosynthetic and regulatory proteins may prove useful in eradicating P. aeruginosa from this environment. Our research has dealt with elucidating the biosynthetic pathway and regulatory mechanism(s) responsible for alginate synthesis by P. aeruginosa. This review summarizes reports on the role of alginate in cystic fibrosis-associated pulmonary infections caused by P. aeruginosa and provides details about the biosynthesis and regulation of this exopolysaccharide.

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