An in vitro study of the use of chelating agents in cleaning nickel-contaminated human skin: an alternative approach to preventing nickel allergic contact dermatitis

1998 ◽  
Vol 39 (4) ◽  
pp. 171-181 ◽  
Author(s):  
J. Healy ◽  
S. Johnson ◽  
M. C. Little ◽  
S. Mac Neil
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Human Skin ◽  
Chelating Agents ◽  
In Vitro Study ◽  
Vitro Study ◽  
Alternative Approach ◽  
Allergic Contact

Red Grape Polyphenol Oral Administration improves Immune Response in Women Affected by Nickel-Mediated Allergic Contact Dermatitis

2020 ◽  
Vol 20 ◽  
Author(s):  
Thea Magrone ◽  
Emilio Jirillo ◽  
Manrico Magrone ◽  
Matteo Antonio Russo ◽  
Paolo Romita ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Oral Administration ◽  
Allergic Contact Dermatitis ◽  
Laboratory Data ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Red Grape ◽  
Allergic Contact ◽  
Drop Outs

Background: Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia cultivar), to peripheral lymphomonocytes from patients affected by allergic contact dermatitis (ACD) to nickel (Ni) could reduce release of pro-inflammatory cytokines and nitric oxide (NO), while increasing levels of interleukin (IL)-10, an anti-inflammatory cytokine. Objective: To assess whether an intervention with oral administration of polyphenols leads to a reduction of peripheral biomarkers in ACD patients. Method: At T0, 25 patients affected by ACD to Ni were orally administered with 300 mg polyphenols prodie extracted from seeds of red grape (Nero di Troia cultivar) (NATUR-OX®) for 3 months (T1). Other 25 patients affected by ACD to Ni received placebo only for the same period of time. Serum biomarkers were analyzed at T0 and T1. In both groups seven drop outs were recorded. Result: At T1 in comparison to T0, in treated patients, values of IFN-γ, IL-4, IL-17, PTX3 and NO decreased, while IL-10 levels increased when compared with T0 values. Conversely, in placebo-treated patients no modifications of biomarkers were evaluated at T1. Conclusion: Present laboratory data rely on the anti-oxidant, anti-inflammatory and anti-allergic properties of polyphenols.

scholarly journals Gene Expression Time Course in the Human Skin during Elicitation of Allergic Contact Dermatitis

2007 ◽  
Vol 127 (11) ◽  
pp. 2585-2595 ◽  
Author(s):  
Malene B. Pedersen ◽  
Lone Skov ◽  
Torkil Menné ◽  
Jeanne D. Johansen ◽  
Jørgen Olsen
Keyword(s):  
Gene Expression ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Human Skin ◽  
Time Course ◽  
Allergic Contact ◽  
Expression Time

In vitro study of ethosome penetration in human skin and hypertrophic scar tissue

2012 ◽  
Vol 8 (6) ◽  
pp. 1026-1033 ◽  
Author(s):  
Zhen Zhang ◽  
Yan Wo ◽  
Yixin Zhang ◽  
Danru Wang ◽  
Rong He ◽  
...  
Keyword(s):  
Human Skin ◽  
Hypertrophic Scar ◽  
In Vitro Study ◽  
Scar Tissue ◽  
Vitro Study ◽  
Hypertrophic Scar Tissue

New Treatment of Wound Healing With Allogenic Acellular Human Skin Graft: Preclinical Assessment and In Vitro Study

2020 ◽  
Vol 52 (7) ◽  
pp. 2204-2207
Author(s):  
M. Nita ◽  
J. Pliszczyński ◽  
C. Kowalewski ◽  
K. Woźniak ◽  
A. Eljaszewicz ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Skin Graft ◽  
In Vitro Study ◽  
Vitro Study ◽  
New Treatment

Spatial variation of acoustic parameters in human skin: an in vitro study between 22 and 45 MHz

2002 ◽  
Vol 28 (5) ◽  
pp. 599-615 ◽  
Author(s):  
Matthias Lebertre ◽  
Frédéric Ossant ◽  
Loı̈c Vaillant ◽  
Stéphane Diridollou ◽  
Frédéric Patat
Keyword(s):  
Spatial Variation ◽  
Human Skin ◽  
In Vitro Study ◽  
Vitro Study ◽  
Acoustic Parameters
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