Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population

2011 ◽  
Vol 87 (6) ◽  
pp. 486-493 ◽  
Author(s):  
Jian Zheng ◽  
Suning Chen ◽  
Lan Jiang ◽  
Yonghe You ◽  
Depei Wu ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Genetic Variations ◽  
Cyclooxygenase 2 ◽  
Acute Myeloid

scholarly journals Polymorphisms of the CYR61 gene in patients with acute myeloid leukemia in a Han Chinese population

Medicine ◽  
2018 ◽  
Vol 97 (34) ◽  
pp. e11963 ◽  
Author(s):  
Chang-Chun Niu ◽  
Ya-Fang Wan ◽  
Cheng Yang ◽  
Tian Li ◽  
Pu Liao
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Acute Myeloid

Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population

2015 ◽  
Vol 142 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Songyu Cao ◽  
Guohua Yang ◽  
Juan Zhang ◽  
Yunfeng Shen ◽  
Hongxia Ma ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Replication Analysis ◽  
Acute Myeloid

scholarly journals Re: Cyclooxygenase-2, prostaglandin E2 and acute myeloid leukemia

2010 ◽  
Vol 31 (5) ◽  
pp. 954-954
Author(s):  
M. H. Chien ◽  
M. L. Kuo ◽  
L. H. Wei
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prostaglandin E2 ◽  
Myeloid Leukemia ◽  
Cyclooxygenase 2 ◽  
Acute Myeloid

The Activator of Transcription 3 (STAT3) Gene Polymorphisms Are Associated with Treatment Outcomes In Acute Myeloid Leukemia

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4858-4858
Author(s):  
Bao-An Chen ◽  
Yue-jiao Zhong ◽  
Ji-feng Feng ◽  
Lu Cheng ◽  
Yufeng Li ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Conflicts Of Interest ◽  
Strong Relationship ◽  
Cellular Transformation ◽  
Janus Kinase ◽  
Nucleotide Polymorphisms ◽  
Free Survival ◽  
Acute Myeloid

Abstract Abstract 4858 Objectives: In the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway signaling pathway, the STAT3 is one of the most prominent predictable factors for cancer and leukemia. STAT3 activation might promote cellular transformation and therefore have an important role in human tumors. This study was aimed to investigate the relationship between the STAT3 polymorphisms and the treatment responses of AML in the Chinese population. Methods: We tested three single nucleotide polymorphisms (SNPs) with 130 Acute Myeloid Leukemia (AML) patients. Genomic DNA was isolated from peripheral blood and assayed by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF). Results: The results showed there were strong relationship between unfavorable cytogenetic, partial remission (even no remission) and the frequencies of GG genotype in rs9909659 (P=0.01 and 0.03) and the patients less than 45 years old was significant association with GA/AA genotype (P=0.01). But associations were not confirmed about event-free survival and leukemia-free survival in the Chinese population studied. Conclusions: It is clear that the AML patients with GG genotype in rs9909659 are not sensitive to standard chemotherapy method Disclosures: No relevant conflicts of interest to declare.

NBS1 rs1805794G>C polymorphism is associated with decreased risk of acute myeloid leukemia in a Chinese population

2013 ◽  
Vol 40 (5) ◽  
pp. 3749-3756 ◽  
Author(s):  
Na Li ◽  
Yanzhe Xu ◽  
Jian Zheng ◽  
Lan Jiang ◽  
Yonghe You ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Acute Myeloid
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