Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population

2015 ◽  
Vol 142 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Songyu Cao ◽  
Guohua Yang ◽  
Juan Zhang ◽  
Yunfeng Shen ◽  
Hongxia Ma ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Replication Analysis ◽  
Acute Myeloid

scholarly journals Polymorphisms of the CYR61 gene in patients with acute myeloid leukemia in a Han Chinese population

Medicine ◽  
2018 ◽  
Vol 97 (34) ◽  
pp. e11963 ◽  
Author(s):  
Chang-Chun Niu ◽  
Ya-Fang Wan ◽  
Cheng Yang ◽  
Tian Li ◽  
Pu Liao
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Acute Myeloid

The Activator of Transcription 3 (STAT3) Gene Polymorphisms Are Associated with Treatment Outcomes In Acute Myeloid Leukemia

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4858-4858
Author(s):  
Bao-An Chen ◽  
Yue-jiao Zhong ◽  
Ji-feng Feng ◽  
Lu Cheng ◽  
Yufeng Li ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Conflicts Of Interest ◽  
Strong Relationship ◽  
Cellular Transformation ◽  
Janus Kinase ◽  
Nucleotide Polymorphisms ◽  
Free Survival ◽  
Acute Myeloid

Abstract Abstract 4858 Objectives: In the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway signaling pathway, the STAT3 is one of the most prominent predictable factors for cancer and leukemia. STAT3 activation might promote cellular transformation and therefore have an important role in human tumors. This study was aimed to investigate the relationship between the STAT3 polymorphisms and the treatment responses of AML in the Chinese population. Methods: We tested three single nucleotide polymorphisms (SNPs) with 130 Acute Myeloid Leukemia (AML) patients. Genomic DNA was isolated from peripheral blood and assayed by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF). Results: The results showed there were strong relationship between unfavorable cytogenetic, partial remission (even no remission) and the frequencies of GG genotype in rs9909659 (P=0.01 and 0.03) and the patients less than 45 years old was significant association with GA/AA genotype (P=0.01). But associations were not confirmed about event-free survival and leukemia-free survival in the Chinese population studied. Conclusions: It is clear that the AML patients with GG genotype in rs9909659 are not sensitive to standard chemotherapy method Disclosures: No relevant conflicts of interest to declare.

NBS1 rs1805794G>C polymorphism is associated with decreased risk of acute myeloid leukemia in a Chinese population

2013 ◽  
Vol 40 (5) ◽  
pp. 3749-3756 ◽  
Author(s):  
Na Li ◽  
Yanzhe Xu ◽  
Jian Zheng ◽  
Lan Jiang ◽  
Yonghe You ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Acute Myeloid

Age-Specific Distributions of Cytogenetic Subgroups of Acute Myeloid Leukemia: Data Analysis in a Chinese Population

2013 ◽  
Vol 129 (3) ◽  
pp. 175-181 ◽  
Author(s):  
Long Su ◽  
SuJun Gao ◽  
Wei Li ◽  
YeHui Tan ◽  
Lei Yang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Data Analysis ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Leukemia Data ◽  
Acute Myeloid

Association of Polymorphisms of Cytosine Arabinoside- Metabolizing Enzyme Gene with Therapy Efficacy for Acute Myeloid Leukemia

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4328-4328
Author(s):  
Peipei Xu ◽  
Baoan Chen ◽  
Ran Liu ◽  
Jifeng Feng ◽  
Lu Cheng ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Cytosine Arabinoside ◽  
Chinese Population ◽  
Myeloid Leukemia ◽  
Conflicts Of Interest ◽  
Cytidine Deaminase ◽  
White Blood Count ◽  
Chemotherapy Response ◽  
Nucleotide Polymorphisms ◽  
Acute Myeloid

Abstract Abstract 4328 Background The cytosine arabinoside (Ara-C)-based chemotherapy is the major remedial measure for acute myeloid leukemia (AML). Deoxycytidine kinase (DCK) and cytidine deaminase (CDA) are the key enzymes in the metabolism of Ara-C. Many single nucleotide polymorphisms (SNPs) and haplotypes of DCK and CDA, which contribute to susceptibility to Ara-C, have been identified in Africans and Europeans. However, there has been no report about the relation among three SNPs in DCK (rs115543896, rs72552079, and rs111454937) and two SNPs in CDA (rs2072671 and rs60369023), and their clinical response to Ara-C for a Chinese population. In this study, we aimed to investigate whether these five SNPs are associated with the therapeutic outcomes of Ara-C-based chemotherapy regimens in patients with AML. Methods A total of 151 patients with AML in a Chinese population were enrolled in our study. SNPs genotyping were performed using the MassARRAY system (Sequenom) by means of the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS) method. Results The results illustrated that DCKrs111454937 AA genotype was more frequent in patients with higher platelet count, and A allele frequency was significantly higher in the group £40 years, lower white blood count (WBC) patients group and the group with platelet counts >60′109/L. Meanwhile, both DCKrs72552079 TC (OR=1.225, 95% CI=1.225–9.851, P=0.0192) and CDArs60369023 GA (OR=9.851, 95% CI=1.31–77.93, P=0.0263) significantly improved Ara-C-based chemotherapy response. While DCKrs11554389 AA (OR=0.147, 95% CI=0.027–0.801, P=0.0267) was associated with the decrease of Ara-C-based chemotherapy response. Conclusion It is evident that the DCK and CDA polymorphisms might be the important markers for the AML patients' therapy outcomes in a Chinese population. Disclosures: No relevant conflicts of interest to declare.

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