Cutaneous Pain Elicited in Man by Thermal Radiation: Dependence of the Threshold Intensity on Stimulation Time, Skin Temperature and Analgesics

2009 ◽  
Vol 10 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Per Otto Andrell
1962 ◽  
Vol 17 (4) ◽  
pp. 693-696 ◽  
Author(s):  
Leon C. Greene ◽  
James D. Hardy

Cutaneous pain thresholds were determined on blackened skin of foreheads and forearms of human subjects over areas of 16 cm2 by recording skin temperature during exposure to thermal radiation for periods up to 50 min. Intensity of stimulus was controlled by the subject so that threshold pain was maintained throughout the exposure. After the initial period of adjustment by the subject, radiation intensity was generally maintained constant although skin temperature for the pain threshold decreased from 44.9 C to 43.8 C. By using an intensity as low as 22 mcal/cm2/sec, threshold pain was evoked in 29 min at a skin temperature of 42.2 C. In both groups, once pain had been established it did not disappear. It is inferred from these observations that thermal pain does not adapt for near-threshold stimulation in the period between onset of pain at 30 sec and termination of stimulation. Submitted on December 26, 1961


1965 ◽  
Vol 20 (5) ◽  
pp. 1006-1013 ◽  
Author(s):  
J. A. J. Stolwijk ◽  
J. D. Hardy

Radiometric measurements have been made of the skin temperature changes occurring during irradiation of the body by high-intensity thermal radiation with square-wave pulses. A quartz lamp bank provided a source of color temperature of 2,650 K and a uniform (± 5%) irradiance of 0.16 cal/sec per cm2 over areas of 40 x 30 cm. A spring-operated focal-plane shutter controlled exposure times from 2–120 sec with a rise time of 0.01 sec. The radiometer, mounted between the quartz lamps so as to view the skin from normal incidence, had a 96% response time of 0.1 sec and a precision of ± 0.1 C. When corrections were made to allow for the far infrared radiation reflected from the skin, the radiometer gave accurate measurements of skin temperature during the periods of irradiation. Experimental values of skin temperature rise were compared with those calculated by the finite differences method for various skin layers using the best available values for optical and thermal properties of each skin layer. During the initial 10–15 sec of irradiation, theoretical and experimental values were in agreement, indicating passive response of the skin to thermal radiation. Subcutaneous temperatures, calculated from surface temperature data, indicated a high degree of penetration of the radiation 0.2–0.4 mm below the skin surface. mathematical model; infrared reflection by the skin; radiometric measurement of skin temperatures Submitted on September 2, 1964


1959 ◽  
Vol 14 (3) ◽  
pp. 373-382 ◽  
Author(s):  
Alice M. Stoll ◽  
Leon C. Greene

Sites on the volar surfaces of the forearms of human subjects were blackened with India ink and exposed to thermal irradiances of from 50 to 400 mcal/cm2 sec. The exposure time and skin temperature at which threshold pain occurred, and which produced minimal blistering within 24 hours, were noted. The thermal inertia (k⍴c) of the skin was shown to vary directly with the level of irradiance. The receptors effective in mediating the pain sensation were calculated to be at a depth of approximately 200 μ and to have a threshold of approximately 43.2℃. Tissue damage rates with respect to temperature were derived empirically so that damage integrated over the time for which skin temperature was elevated over the pain threshold was equated to unity. The substitution of the ratio of these rates with respect to temperature for the stimulus ratio, in the prediction of the observed discriminable steps in pain sensation intensity, yielded faithful reproduction of the just noticeable differences observed for pain through the range of this sensation. Submitted on September 17, 1958


1962 ◽  
Vol 17 (6) ◽  
pp. 1009-1012 ◽  
Author(s):  
Charles E. Rice ◽  
D. R. Kenshalo

Five cats were trained to give a leg-lift response in order to turn off a thermal radiation source. The minimum duration of thermal radiation that would consistently evoke a leg-lift response was taken to be the noxious threshold. The mean calculated skin temperature for the five experimental cats, at threshold, was 52.6 ± 0.35 C. This is compared to a mean calculated skin temperature of 44.5 ± 0.13 C for human subjects under identical conditions of stimulation. Submitted on June 4, 1962


Science ◽  
1951 ◽  
Vol 114 (2954) ◽  
pp. 149-150 ◽  
Author(s):  
J. D. Hardy ◽  
H. Goodell ◽  
H. G. Wolff

1957 ◽  
Vol 189 (1) ◽  
pp. 1-5 ◽  
Author(s):  
J. D. Hardy ◽  
A. M. Stoll ◽  
D. Cunningham ◽  
W. M. Benson ◽  
L. Greene

Using the method of rapid measurement of skin temperature during exposure to known amounts of thermal radiation, the ‘thermal inertia’ or kpc product ( k = thermal conductivity, p = density, c = specific heat) was measured for the rat skin. An average kpc value of 84 ± 18 x 10–5 cal2/cm4/sec/°C2 was obtained for the lightly anesthetized animal. This value was independent of the intensity of the radiation, the method of exposing the skin; i.e., shaving, clipping, or depilating, and anesthesia. Administration of 200 mg/kg of azapetine phosphate, a potent adrenolytic agent, was accompanied by a marked drop in skin temperature (4–5°C), but no statistically significant change was observed in the kpc values when compared with the controls. Unanesthetized animals were exposed to high intensity thermal radiation and the animals' reactions observed. Two reactions could be identified, the skin twitch and the escape or withdrawal reactions, occurring at average skin temperatures of 45–46°C and 51–52°C, respectively. A possible correspondence of these reactions to those previously observed to occur in man at these temperatures; i.e., pain threshold and wince threshold, was noted.


Author(s):  
Yoshihito Kurazumi ◽  
Kenta Fukagawa ◽  
Tomonori Sakoi ◽  
Ariya Aruninta ◽  
Ken Yamashita

Depending on human body conditions and environmental conditions, it is sometimes difficult to conduct subject experiments. In such cases, it is effective to use a thermal manikin. There are few studies that investigate the effect of the non-uniform and asymmetric outdoor thermal environment on the mean skin temperature. The purpose of this study is to clarify the influence of the non-uniform and asymmetric thermal radiation of short-wavelength solar radiation in an outdoor environment on the calculation of the mean skin temperature. The skin temperature of the front of the coronal surface, which was facing the sun and where the body received direct short-wavelength solar radiation, and the skin temperature of the rear of the coronal surface, which was in the shadow and did not receive direct short-wavelength solar radiation were respectively measured. The feet, upper arm, forearm, hand and lower leg, which are susceptible to short-wavelength solar radiation in a standing posture, had a noticeable difference in skin temperature between sites in the sun and in shade. The mean skin temperature of sites facing the sun was significantly higher than the mean skin temperature of those in the shade.


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