Serotonin Receptors in the Brain of Rats Treated Chronically with Lithium Administered via the Food or by Intraperitoneal Injections

1992 ◽  
Vol 70 (1) ◽  
pp. 72-74 ◽  
Author(s):  
Helle Johanning ◽  
Erling Mellerup ◽  
Per Plenge
Keyword(s):  
Serotonin Receptors ◽  
The Brain

Substituted N,N-Dimethyl-3-(phenylthio)- and -4-(phenylthio)benzylamines

1992 ◽  
Vol 57 (1) ◽  
pp. 194-203 ◽  
Author(s):  
Karel Šindelář ◽  
Vojtěch Kmoníček ◽  
Marta Hrubantová ◽  
Zdeněk Polívka
Keyword(s):  
Serotonin Receptors ◽  
Hydrobromic Acid ◽  
Antidepressant Activity ◽  
Benzoic Acids ◽  
Lithium Aluminium Hydride ◽  
Acid Chlorides ◽  
Activity Inhibition ◽  
Lithium Aluminium ◽  
The Brain

(Arylthio)benzoic acids IIa - IIe and VIb - VId were transformed via the acid chlorides to the N,N-dimethylamides which were reduced either with diborane "in situ" or with lithium aluminium hydride to N,N-dimethyl-(arylthio)benzylamines Ia - Ie and Vb - Vd. Leuckart reaction of the aldehydes IX and X with dimethylformamide and formic acid afforded directly the amines Va and Ve. Demethylation of the methoxy compounds Ia and Ve with hydrobromic acid resulted in the phenolic amines If and Vf. The most interesting N,N-dimethyl-4-(phenylthio)benzylamine (Va) hydrochloride showed affinity to cholinergic and 5-HT2 serotonin receptors in the rat brain and some properties considered indicative of antidepressant activity (inhibition of serotonin re-uptake in the brain and potentiation of yohimbine toxicity in mice).

Regulation of Serotonin Receptors and Responsiveness in the Brain

1988 ◽  
pp. 319-362 ◽  
Author(s):  
Alan Frazer ◽  
Steve J. Offord ◽  
Irwin Lucki
Keyword(s):  
Serotonin Receptors ◽  
The Brain

Expression Patterns of Serotonin Receptors 1А and 7 in the Brain of Rats with Genetically Determined Fear-Induced Aggressive Behavior or the Lack of Aggression

2020 ◽  
Vol 14 (2) ◽  
pp. 180-186
Author(s):  
T. V. Ilchibaeva ◽  
A. S. Tsybko ◽  
E. M. Kondaurova ◽  
A. I. Kovetskaya ◽  
R. V. Kozhemyakina ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Serotonin Receptors ◽  
Expression Patterns ◽  
Genetically Determined ◽  
The Brain

scholarly journals Clinical potential of psilocybin as a treatment for mental health conditions

2017 ◽  
Vol 7 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Jeremy Daniel ◽  
Margaret Haberman
Keyword(s):  
Mental Health ◽  
Serotonin Receptors ◽  
Alcohol Use Disorder ◽  
Health Conditions ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Tobacco Use Disorder ◽  
Disease States ◽  
Clinical Potential ◽  
The Brain

Abstract Psilocybin, a classic hallucinogen, is a chemical produced by more than 100 species of mushrooms worldwide. It has high affinity for several serotonin receptors, including 5-HT1A, 5-HT2A, and 5-HT2C, located in numerous areas of the brain, including the cerebral cortex and thalamus. With legislation introduced in 1992, more work is being done to further understand the implications of psilocybin use in a number of disease states. Certain mental health disease states and symptoms have been studied, including depressed mood, anxiety disorders, obsessive-compulsive disorder, alcohol use disorder, and tobacco use disorder. This article provides an in-depth review of the study design and results of psilocybin in each of these conditions and discusses the clinical potential for use.

Serotonin receptors in experimental hepatic encephalopathy — Regional changes in the brain

1997 ◽  
Vol 42 (1) ◽  
pp. 106S
Author(s):  
G. Apelqvist ◽  
P.B.F. Bergqvist ◽  
B. Larsson ◽  
M. Bugge ◽  
F. Bengtsson
Keyword(s):  
Hepatic Encephalopathy ◽  
Serotonin Receptors ◽  
The Brain ◽  
Experimental Hepatic Encephalopathy

scholarly journals PROMISING DIRECTIONS FOR THE APPLICATION OF PIPERIDINE DERIVATIVES AS STRUCTURAL COMPONENTS OF NEUROTROPIC DRUGS

2021 ◽  
Vol 20 (2) ◽  
pp. 8-17
Author(s):  
A.A. Vasilyuk ◽  
◽  
V.I. Kozlovsky ◽  
Keyword(s):  
Serotonin Receptors ◽  
Partial Epilepsy ◽  
Structural Components ◽  
Antiepileptic Agent ◽  
Hyperactivity Disorder ◽  
Antipsychotic Activity ◽  
Dopamine And Serotonin Receptors ◽  
Neurotropic Drugs ◽  
New Compounds ◽  
The Brain

Piperidine is one of the most common heterocycles, and its derivatives are found in many pharmacological groups, including neurotropic drugs. These compounds are numerous among analgesics, and, in addition to “classical” promedol, fentanyl and its derivatives, the paper presents the results of studying new compounds with analgesic activity and piperidine cycle. Reviews of such piperidine antipsychotics as haloperidol and risperidone have been considered, and new compounds showing antipsychotic activity through their effects on dopamine and serotonin receptors have been elucidated. The data on the influence of methylphenidate on the brain in case of attention deficit/ hyperactivity disorder (ADHD) have been analyzed, which help to understand the disturbances occurring in this disease. Tiagabine has been considered as an antiepileptic agent reducing the number of seizures in resistant forms of partial epilepsy, as well as the activation of microglia and may be effective in neurodegenerative diseases. The last section is devoted to drugs for the treatment of Alzheimer’s disease (AD), namely donepezil, its modifications, and some new compounds potentially capable of inhibiting AD progression through the inhibition of Aβ42 protein synthesis.

Serotonin Receptors in the Brain following Total Hepatectomy in Rats Treated with Branched-Chain Amino Acids

1989 ◽  
Vol 13 (3) ◽  
pp. 235-239 ◽  
Author(s):  
M. Bugge ◽  
F. Bengtsson ◽  
H. Hall ◽  
I. Wedel ◽  
A. Nobin ◽  
...  
Keyword(s):  
Amino Acids ◽  
Serotonin Receptors ◽  
Branched Chain Amino Acids ◽  
Branched Chain ◽  
The Brain
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