Correlation Between Regional Specificity of Antisperm Antibodies to the Spermatozoan Surface and Complement-Mediated Sperm Immobilization

1982 ◽  
Vol 2 (4) ◽  
pp. 222-224 ◽  
Author(s):  
R.A. BRONSON ◽  
G.W. COOPER ◽  
D.L. ROSENFELD
Keyword(s):  
Antisperm Antibodies ◽  
Regional Specificity ◽  
Sperm Immobilization

scholarly journals Human sperm carbohydrate antigens defined by an antisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum.

1988 ◽  
Vol 168 (1) ◽  
pp. 343-356 ◽  
Author(s):  
Y Tsuji ◽  
H Clausen ◽  
E Nudelman ◽  
T Kaizu ◽  
S Hakomori ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Human Monoclonal Antibody ◽  
Human Sperm ◽  
Infertile Woman ◽  
Antisperm Antibodies ◽  
Infertile Women ◽  
Epitope Structure ◽  
Sperm Immobilization ◽  
Sperm Antigen

The epitope structure of the human sperm antigen reacting with antibodies present in sera of infertile women has been studied using mAb H6-3C4, which produces immobilization of human sperm in the presence of complement. Another antibody, NUH2, which also induces human sperm immobilization, was used to substantiate the presence of a receptor on sperm involved in susceptibility to immobilization. Both antibodies defined type 2 chain polylactosamine structure. H6-3C4 is directed to internally located repetitive N-acetyllactosamine, i.e., sialyl-i, i, or fucosyl-i. NUH2 defines binary alpha 2----3 sialyl type 2 chain, i.e., sialyl-I. Thus, the presence of antibodies in the sera of infertile women directed to sperm lactosaminoglycan or lactosaminolipid could be the basis for infertility in these cases.

1218: Organ Sparing Surgery in Small Testicular Tumors does not Lead to Development of Antisperm Antibodies

2007 ◽  
Vol 177 (4S) ◽  
pp. 401-401
Author(s):  
Nicolai Leonhartsberger ◽  
Thomas Akkad ◽  
Christian Gozzi ◽  
Georg Bartsch ◽  
Hannes Steiner
Keyword(s):  
Antisperm Antibodies ◽  
Testicular Tumors ◽  
Organ Sparing

Analysis method ofrecruitment needs for the regional economy: Occupational section

2017 ◽  
pp. 142-149 ◽  
Author(s):  
E. Pitukhin ◽  
S. Shabaeva ◽  
I. Stepus ◽  
D. Moroz
Keyword(s):  
Cluster Analysis ◽  
Labor Market ◽  
Comparative Analysis ◽  
Regional Economy ◽  
Dimensional Space ◽  
Analysis Method ◽  
Scalar Form ◽  
Regional Labor Market ◽  
Regional Labor ◽  
Regional Specificity

The paper deals with comparative analysis of occupations in the regional labor market. Occupation is treated as a multi-dimensional space of characte- ristics, whereas a scalar form of a characteristic makes it possible to carry out a comparative analysis of occupations. Using cluster analysis of a pilot region indicators five meaningfully interpretable clusters of occupations were identified, reflecting their regional specificity.

scholarly journals Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming

2021 ◽  
Vol 7 (15) ◽  
pp. eabe8978
Author(s):  
Álvaro Herrero-Navarro ◽  
Lorenzo Puche-Aroca ◽  
Verónica Moreno-Juan ◽  
Alejandro Sempere-Ferràndez ◽  
Ana Espinosa ◽  
...  
Keyword(s):  
Molecular Diversity ◽  
Regional Identity ◽  
Brain Regions ◽  
Molecular Signature ◽  
Specific Gene ◽  
Thalamic Nuclei ◽  
Brain Repair ◽  
Cell Diversity ◽  
Regional Specificity ◽  
Epigenetic Signatures

Neural cell diversity is essential to endow distinct brain regions with specific functions. During development, progenitors within these regions are characterized by specific gene expression programs, contributing to the generation of diversity in postmitotic neurons and astrocytes. While the region-specific molecular diversity of neurons and astrocytes is increasingly understood, whether these cells share region-specific programs remains unknown. Here, we show that in the neocortex and thalamus, neurons and astrocytes express shared region-specific transcriptional and epigenetic signatures. These signatures not only distinguish cells across these two brain regions but are also detected across substructures within regions, such as distinct thalamic nuclei, where clonal analysis reveals the existence of common nucleus-specific progenitors for neurons and astrocytes. Consistent with their shared molecular signature, regional specificity is maintained following astrocyte-to-neuron reprogramming. A detailed understanding of these regional-specific signatures may thus inform strategies for future cell-based brain repair.

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