The relationship between the Met allele of the BDNF Val66Met polymorphism and impairments in decision making under ambiguity in patients with obsessive-compulsive disorder

Background: Obsessive-Compulsive Disorder (OCD) is a serious neuropsychiatric disorder. The clinical prominence of the OCD symptoms dimensions and Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism are of significant importance. Objectives: The present study aimed to investigate the symptom dimensions and BDNF val66Met polymorphism genotype in Iranian patients with OCD. Materials and Methods: A total of 83 patients diagnosed with OCD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM5) criteria, and 83 matched controls were included this case-control study. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to investigate symptom dimensions. In addition, BDNF val66Met polymorphism was genotyped using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCRRFLP) method. Results: The obtained data indicated that the most prevalent obsession was contamination (62.6%) and the most prevalent compulsion was cleanliness (69.8%). Furthermore, there was a significant relationship between the genotypes of BDNF val66Met polymorphism in OCD (P<0.01). Besides, carrying the” T” allele confers increased the risk for the presence of OCD [χ2=4.7, P=0.003; OR (95%) 1.93 (1.24-2.99)]. Conclusion: The symptoms dimensions of OCD in the Iranian sample were similar to other populations. Moreover, the findings suggested an association between BDNF val66Met polymorphism genotype and OCD in the explored Iranian sample. The inheritance hypothesis for the TT genotype was the recessive model.

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Do obsessive–compulsive disorder and Tourette syndrome share a common susceptibility gene? An association study of the BDNF Val66Met polymorphism in the Chinese Han population

The World Journal of Biological Psychiatry ◽

10.3109/15622975.2015.1012226 ◽

2015 ◽

Vol 16 (8) ◽

pp. 602-609 ◽

Cited By ~ 10

Author(s):

Shiguo Liu ◽

Jiajia Cui ◽

Zhaoyuan Niu ◽

Mingji Yi ◽

Xinhua Zhang ◽

...

Keyword(s):

Association Study ◽

Obsessive Compulsive Disorder ◽

Tourette Syndrome ◽

Susceptibility Gene ◽

Obsessive Compulsive ◽

Chinese Han ◽

Val66met Polymorphism ◽

Han Population ◽

Compulsive Disorder ◽

Bdnf Val66met Polymorphism

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Meta-analysis of the association of brain-derived neurotrophic factor Val66Met polymorphism with obsessive–compulsive disorder

Acta Neuropsychiatrica ◽

10.1017/neu.2015.38 ◽

2015 ◽

Vol 27 (6) ◽

pp. 327-335 ◽

Cited By ~ 8

Author(s):

Jun Wang ◽

Fuquan Zhang ◽

Wenxian Zhu ◽

Yansong Liu ◽

Zhenhe Zhou

Keyword(s):

Psychiatric Disorders ◽

Obsessive Compulsive Disorder ◽

Neurotrophic Factor ◽

Meta Analysis ◽

Brain Derived Neurotrophic Factor ◽

Genetic Models ◽

Obsessive Compulsive ◽

Val66met Polymorphism ◽

Compulsive Disorder ◽

Bdnf Val66met Polymorphism

ObjectiveBrain-derived neurotrophic factor (BDNF) plays an important role in neural survival and was proposed to be related to psychiatric disorders. Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia. However, studies evaluating its association with obsessive–compulsive disorder (OCD) obtained inconsistent results. The purpose of this study was to derive a more precise estimation of the association between BDNF Val66Met polymorphism and OCD susceptibility by a meta-analysis.MethodWe carried a structured literature search in PubMed, Embase, PsycINFO and Chinese Biomedical Database up to December 2014; and retrieved all eligible case–control studies according to the including criteria. Meta-analysis was performed for four genetic models: allelic model: Met versus Val; additive model: Met/Met versus Val/Val; recessive model: Met/Met versus Val/Val+Val/Met; and dominant model: Val/Met+Met/Met versus Val/Val. Stratified analyses were performed by ethnicity and gender where appropriate.ResultsA total of eight articles with nine studies including 1632 OCD cases and 2417 controls were identified. No significant association was detected in any comparison when the whole data were pooled together or stratified by ethnicity or gender in all four genetic models (p>0.05 for each comparison).ConclusionDespite some limitations, our meta-analysis suggests that no significant association exists between the BDNF Val66Met polymorphism and OCD susceptibility.

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IS BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) VAL66MET POLYMORPHISM ASSOCIATED WITH OBSESSIVE-COMPULSIVE DISORDER? A META-ANALYSIS

Psychiatria Danubina ◽

10.24869/psyd.2019.141 ◽

2019 ◽

Vol 31 (2) ◽

pp. 141-147 ◽

Cited By ~ 2

Author(s):

Shengdong Wang ◽

◽

Shengdong Wang ◽

Xiaohong Xu ◽

Pan Yan ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Neurotrophic Factor ◽

Meta Analysis ◽

Brain Derived Neurotrophic Factor ◽

Obsessive Compulsive ◽

Val66met Polymorphism ◽

Compulsive Disorder ◽

Bdnf Val66met Polymorphism

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Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder

European Psychiatry ◽

10.1016/j.eurpsy.2011.09.005 ◽

2012 ◽

Vol 27 (5) ◽

pp. 386-390 ◽

Cited By ~ 19

Author(s):

M.A. Fullana ◽

P. Alonso ◽

M. Gratacòs ◽

N. Jaurrieta ◽

S. Jiménez-Murcia ◽

...

Keyword(s):

Treatment Response ◽

Obsessive Compulsive Disorder ◽

Behavior Therapy ◽

Cognitive Behavior Therapy ◽

Cognitive Behavior ◽

Obsessive Compulsive ◽

Extinction Learning ◽

Val66met Polymorphism ◽

Compulsive Disorder ◽

Bdnf Val66met Polymorphism

AbstractBackgroundRecent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD).MethodsOne hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed.ResultsAmong 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (P = 0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (P<0.0001) and a lower obsessions severity decrease from pre- to posttreatment (P = 0.046).ConclusionGenetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.

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