scholarly journals Positive association between MET allele (BDNF Val66Met polymorphism) and obsessive-compulsive disorder

2010 ◽  
Vol 32 (3) ◽  
pp. 323-324 ◽  
Author(s):  
Felipe Filardi da Rocha ◽  
Leandro Malloy-Diniz ◽  
Naira Vassalo Lage ◽  
Humberto Corrêa
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Positive Association ◽  
Obsessive Compulsive ◽  
Val66met Polymorphism ◽  
Compulsive Disorder ◽  
Bdnf Val66met Polymorphism

scholarly journals Symptom Dimensions and Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Obsessive-compulsive Disorder

2020 ◽  
Vol 6 (2) ◽  
pp. 84-93
Author(s):  
Shahrzad Hoveyda ◽  
◽  
Javad Khalatbari ◽  
Javid Peymani ◽  
Hasan Ahadi ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Recessive Model ◽  
Obsessive Compulsive ◽  
Val66met Polymorphism ◽  
Symptom Dimensions ◽  
Compulsive Disorder ◽  
Diagnostic And Statistical Manual ◽  
Bdnf Val66met Polymorphism

Background: Obsessive-Compulsive Disorder (OCD) is a serious neuropsychiatric disorder. The clinical prominence of the OCD symptoms dimensions and Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism are of significant importance. Objectives: The present study aimed to investigate the symptom dimensions and BDNF val66Met polymorphism genotype in Iranian patients with OCD. Materials and Methods: A total of 83 patients diagnosed with OCD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM5) criteria, and 83 matched controls were included this case-control study. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to investigate symptom dimensions. In addition, BDNF val66Met polymorphism was genotyped using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCRRFLP) method. Results: The obtained data indicated that the most prevalent obsession was contamination (62.6%) and the most prevalent compulsion was cleanliness (69.8%). Furthermore, there was a significant relationship between the genotypes of BDNF val66Met polymorphism in OCD (P<0.01). Besides, carrying the” T” allele confers increased the risk for the presence of OCD [χ2=4.7, P=0.003; OR (95%) 1.93 (1.24-2.99)]. Conclusion: The symptoms dimensions of OCD in the Iranian sample were similar to other populations. Moreover, the findings suggested an association between BDNF val66Met polymorphism genotype and OCD in the explored Iranian sample. The inheritance hypothesis for the TT genotype was the recessive model.

Meta-analysis of the association of brain-derived neurotrophic factor Val66Met polymorphism with obsessive–compulsive disorder

2015 ◽  
Vol 27 (6) ◽  
pp. 327-335 ◽  
Author(s):  
Jun Wang ◽  
Fuquan Zhang ◽  
Wenxian Zhu ◽  
Yansong Liu ◽  
Zhenhe Zhou
Keyword(s):  
Psychiatric Disorders ◽  
Obsessive Compulsive Disorder ◽  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Genetic Models ◽  
Obsessive Compulsive ◽  
Val66met Polymorphism ◽  
Compulsive Disorder ◽  
Bdnf Val66met Polymorphism

ObjectiveBrain-derived neurotrophic factor (BDNF) plays an important role in neural survival and was proposed to be related to psychiatric disorders. Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia. However, studies evaluating its association with obsessive–compulsive disorder (OCD) obtained inconsistent results. The purpose of this study was to derive a more precise estimation of the association between BDNF Val66Met polymorphism and OCD susceptibility by a meta-analysis.MethodWe carried a structured literature search in PubMed, Embase, PsycINFO and Chinese Biomedical Database up to December 2014; and retrieved all eligible case–control studies according to the including criteria. Meta-analysis was performed for four genetic models: allelic model: Met versus Val; additive model: Met/Met versus Val/Val; recessive model: Met/Met versus Val/Val+Val/Met; and dominant model: Val/Met+Met/Met versus Val/Val. Stratified analyses were performed by ethnicity and gender where appropriate.ResultsA total of eight articles with nine studies including 1632 OCD cases and 2417 controls were identified. No significant association was detected in any comparison when the whole data were pooled together or stratified by ethnicity or gender in all four genetic models (p>0.05 for each comparison).ConclusionDespite some limitations, our meta-analysis suggests that no significant association exists between the BDNF Val66Met polymorphism and OCD susceptibility.

Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder

2012 ◽  
Vol 27 (5) ◽  
pp. 386-390 ◽  
Author(s):  
M.A. Fullana ◽  
P. Alonso ◽  
M. Gratacòs ◽  
N. Jaurrieta ◽  
S. Jiménez-Murcia ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Behavior Therapy ◽  
Cognitive Behavior Therapy ◽  
Cognitive Behavior ◽  
Obsessive Compulsive ◽  
Extinction Learning ◽  
Val66met Polymorphism ◽  
Compulsive Disorder ◽  
Bdnf Val66met Polymorphism

AbstractBackgroundRecent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD).MethodsOne hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed.ResultsAmong 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (P = 0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (P<0.0001) and a lower obsessions severity decrease from pre- to posttreatment (P = 0.046).ConclusionGenetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.

Impact of brain-derived neurotrophic factor Val66Met polymorphism and response to escitalopram or paroxetine in obsessive–compulsive disorder

CNS Spectrums ◽  
2021 ◽  
pp. 1-7
Author(s):  
Ghina Harika-Germaneau ◽  
Nicolas Langbour ◽  
Sylvie Patri ◽  
Marcello Solinas ◽  
Armand Chatard ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Response To Treatment ◽  
Obsessive Compulsive ◽  
Val66met Polymorphism ◽  
Symptom Dimensions ◽  
Compulsive Disorder ◽  
Symptom Dimension ◽  
The Impact

Abstract Objective Obsessive–compulsive disorder (OCD) is a severe psychiatric disorder characterized by its heterogeneous nature and by different dimensions of obsessive–compulsive (OC) symptoms. Serotonin reuptake inhibitors (SRIs) are used to treat OCD, but up to 40% to 60% of patients do not show a significant improvement with these medications. In this study, we aimed to test the impact of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the efficacy of antidepressants in OCD overall, and in relation to the different OC dimensions. Methods In a 6-month prospective treatment study, 69 Caucasian OCD patients were treated with escitalopram for 24 weeks or with escitalopram for 12 weeks followed by paroxetine for an additional 12-week period. Patients were genotyped and assessed for treatment response. The main clinical outcomes were improvement of the Yale-Brown Obsessive–Compulsive Scale score and in different OC symptom dimension scores. Results The Val/Val group comprised 43 (62%) patients, the Val/Met and Met/Met group comprised 26 (38%) patients. Forty-two patients were classified as responders at 12 weeks and 38 at 24 weeks; no significant association was found between BDNF Val66Met and SRIs response at 12 and 24 weeks. In analyses of the different OC symptom dimensions, the Met allele was associated with a slightly reduced score in the aggressive/checking dimension at 6 months (P = .048). Conclusions Our findings do not support the usefulness of BDNF Val66Met genotyping to predict overall response to treatment with SRIs in OCD; they did however suggest a better outcome at 6 months for the aggressive/checking symptom dimension for patients carrying the Met allele.

Hypogyrification in obsessive-compulsive disorder

2016 ◽  
Vol 47 (6) ◽  
pp. 1053-1061 ◽  
Author(s):  
O. G. Rus ◽  
T. J. Reess ◽  
G. Wagner ◽  
M. Zaudig ◽  
C. Zimmer ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Symptom Severity ◽  
Healthy Subjects ◽  
Age Of Onset ◽  
Positive Association ◽  
Cortical Folding ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Co Morbidity ◽  
Gyrification Index

BackgroundPrevious studies hypothesized that neurodevelopmental risk factors may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Cortical folding has been shown to be a reliable indicator for normal and altered neurodevelopment, but in OCD it has barely been investigated up to now. The present study investigates whether alterations in gyrification are detectable in OCD and, if so, how these are associated with clinical characteristics.MethodWe compared the local Gyrification Index (lGI) between 75 OCD patients and 75 matched healthy subjects across the whole brain. In addition, for those regions exhibiting an altered lGI in patients we explored a potential relationship to symptom severity, age of onset, and influence of medication.ResultsOCD patients had a significantly decreased lGI in right parietal, precentral but also insula, temporal, pars triangularis and rostral middle frontal regions compared to healthy subjects. A positive association with age of onset was found but no association with symptom severity. There was no effect of co-morbidity or medication.ConclusionsThe reduced gyrification found in OCD confirms previous findings in other psychiatric disorders and suggests that alterations may already occur during early stages of brain development. Our findings support the idea that altered cortical folding might represent a trait characteristic of the disorder although longitudinal studies are needed to clarify the trajectory of this morphological measure in OCD.

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