Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population

2007 ◽  
Vol 19 (6) ◽  
pp. 344-350 ◽  
Author(s):  
Hsin-An Chang ◽  
Ru-Band Lu ◽  
Wei-Wen Lin ◽  
Chuan-Chia Chang ◽  
Chih-Lun Chen ◽  
...  
Keyword(s):  
Chinese Population ◽  
Han Chinese ◽  
Psychotic Symptoms ◽  
Positive Symptoms ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Han Chinese Population ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
Dopamine D3

Background:The Ser9Gly polymorphism in dopamine D3 receptor gene (DRD3) was considered an important factor in the pathogenesis of schizophrenia. Allele and genotype frequencies of this polymorphism were studied in different ethnic groups of schizophrenic patients. However, the results have been inconclusive.Objective:To determine whether the DRD3 Ser9Gly polymorphism is associated with schizophrenia or influences its psychopathological symptoms in Han Chinese population.Method:We recruited 256 schizophrenic patients and 285 normal controls matched for gender, age and ethnicity. Pretreatment psychotic symptoms were evaluated with the Positive and Negative Symptom Scale (PANSS) in 128 acutely exacerbated schizophrenic in-patients. Genotyping of Ser9Gly polymorphism was performed with a polymerase chain reaction restriction fragment length polymorphism method and reconfirmed by a direct sequencing technique.Results:No significant difference was found between either patients with schizophrenia or with more homogeneous schizophrenic subgroups and healthy controls in genotype distributions and allele frequencies for the DRD3 Ser9Gly polymorphism. Similarly, DRD3 Ser9Gly genotype differences failed to reach significance in PANSS global, positive, negative and general symptoms scores. There is a trend (P = 0.064) towards higher PANSS positive symptoms scores in subjects carrying the Gly/Gly genotype.Conclusion:This study does not support the role of DRD3 Ser9Gly polymorphism in increasing genetic risk for schizophrenia in Han Chinese population. Still, there is a possibility that the DRD3 Ser9Gly variant may reflect genetic variation of severity of positive symptoms in acutely exacerbated schizophrenia. Further studies are warranted to investigate the effect of the DRD3 Ser9Gly polymorphism in relation to longer time course of schizophrenia, including treatment response to antipsychotics.

scholarly journals Risk Factors for Gastric Cancer-Associated Thrombotic Diseases in a Han Chinese Population

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Bo Song ◽  
Yamei Wang ◽  
Xiuzhi Zhu ◽  
Li Zhang ◽  
Hui Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Chinese Population ◽  
Han Chinese ◽  
Preventive Strategy ◽  
Diabetes Surgery ◽  
Han Chinese Population ◽  
Related Data ◽  
Significant Difference ◽  
Thrombotic Diseases

The aim of the present work was to investigate the risk factors for gastric cancer- (GC-) associated thrombotic diseases in a Han Chinese population. A total of 333 patients diagnosed with GC, 68 with thrombotic diseases included in the case group and the remaining 265 in the control group, were enrolled. The relevant data for the participants, including general information (gender, age, smoking, and drinking), comorbidities (diabetes, hypertension, and anemia), tumor-related data (tumor site, histology, degree of differentiation, and clinical stage), and treatment-related data (surgery, chemotherapy, hormones, transfusion, and peripherally inserted central venous catheter (PICC)), were collected. Statistically significant factors derived from univariate analyses were then subjected to multivariate logistic regression analyses. The results demonstrate a statistically significant difference in age, diabetes, hypertension, histology, surgery, chemotherapy, and PICC ( P < 0.05 ), compared with control. Age, diabetes, surgery, and PICC serve as independent risk factors for GC-associated thrombotic diseases ( P < 0.05 ). The present work demonstrates that GC-associated thrombotic diseases are significantly associated with age, diabetes, surgery, and PICC, suggesting a potential target for early detection and preventive strategy for GC patients with thrombophilia.

scholarly journals Homozygosity for the Gly-9 variant of the dopamine D3 receptor and risk for tardive dyskinesia in schizophrenic patients

2000 ◽  
Vol 3 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Roger Løvlie ◽  
Ann K. Daly ◽  
Richard Blennerhassett ◽  
Nicol Ferrier ◽  
Vidar M. Steen
Keyword(s):  
Tardive Dyskinesia ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Schizophrenic Patients ◽  
Dopamine D3

scholarly journals Association of Polymorphisms of the Receptor for Advanced Glycation Endproducts Gene with Schizophrenia in a Han Chinese Population

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jiawu Fu ◽  
Xiang Zuo ◽  
Jingwen Yin ◽  
Xudong Luo ◽  
Zheng Li ◽  
...  
Keyword(s):  
Chinese Population ◽  
Advanced Glycation Endproducts ◽  
Han Chinese ◽  
Immunoglobulin Superfamily ◽  
Psychotic Symptoms ◽  
Nucleotide Polymorphisms ◽  
Advanced Glycation ◽  
Han Chinese Population ◽  
Glycation Endproducts ◽  
Inflammatory Damage

Receptor for Advanced Glycation Endproducts (RAGE) is a member of the immunoglobulin superfamily that binds diverse ligands involved in the development of inflammatory damage and diverse chronic diseases including schizophrenia. Here, three single-nucleotide polymorphisms (SNPs) (G82S, -374T/A, and -429T/C) in the RAGE gene were genotyped in 923 patients with schizophrenia and 874 healthy-matched controls in a Han Chinese population using the SNaPshot technique. Additionally, we investigated the association among aforementioned SNPs with the clinical psychotic symptoms of the patients and neurocognitive function. Our study demonstrated that the frequencies of the TC + CC genotypes and the C allele in the -429T/C polymorphism were significantly lower in the patients compared with the controls (p=0.031 and p=0.034, resp.). However, the significant effect disappeared when using Bonferroni correction (p=0.093 and p=0.102, resp.). And there were no significant differences in the genotype and allele frequencies between the patients and the controls for G82S and -374T/A polymorphisms. Additionally, the -429T/C C allele carriers had marginally higher Symbol coding scores than the subjects with the TT genotypes [p=0.031 and p (corr) = 0.093]. Our data indicate that the RAGE -429T/C polymorphism may be associated with the susceptibility of schizophrenia.

scholarly journals Ser9Gly dopamine D3 receptor polymorphism and spontaneous dyskinesia in never-medicated schizophrenic patients

2000 ◽  
Vol 6 (1) ◽  
pp. 6-7 ◽  
Author(s):  
R Løvlie ◽  
R Thara ◽  
R Padmavathi ◽  
V M Steen ◽  
R G McCreadie
Keyword(s):  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Schizophrenic Patients ◽  
Dopamine D3 ◽  
Receptor Polymorphism

Association ofNKAPL,TSPAN18, andMPC2gene variants with schizophrenia based on new data and a meta-analysis in Han Chinese

2016 ◽  
Vol 29 (2) ◽  
pp. 87-94 ◽  
Author(s):  
Zhen Li ◽  
Tingting Shen ◽  
Ran Xin ◽  
Baoyun Liang ◽  
Juan Jiang ◽  
...  
Keyword(s):  
Chinese Population ◽  
Association Studies ◽  
Meta Analysis ◽  
Han Chinese ◽  
Genome Wide Association Studies ◽  
Han Chinese Population ◽  
Genotype Frequencies ◽  
Genome Wide ◽  
Significant Difference ◽  
High Heritability

BackgroundSchizophrenia (SZ) is suggested to be a complex polygenetic disorder with high heritability. Genome-wide association studies have found that the rs1635, rs11038167, and rs10489202 polymorphisms are associated with SZ in Han Chinese. However, results of validation studies are inconsistent. This study aimed to test the association between theNKAPLrs1635,TSPAN18rs11038167, andMPC2rs10489202 polymorphisms and SZ in a Chinese population.MethodsThis study contained 700 unrelated SZ patients (300 Zhuang and 400 Han) and 700 gender- and age-matched controls (300 Zhuang and 400 Han). The polymorphisms inTSPAN18(rs11038167),NKAPL(rs1635), andMPC2(rs10489202) were genotyped using the Sequenom MassARRAY method. Statistical analyses were performed with PLINK program and SPSS l6.0 for Windows. STATA11.1 was used for meta-analysis.ResultsNo statistically significant difference was found in different allele and genotype frequencies of rs1635, rs11038167, and rs10489202 between SZ cases and controls of Zhuang and Han ethnicities and the total samples (allp>0.05). Further meta-analysis suggested that single-nucleotide polymorphism rs10489202 was significantly associated with SZ in a Han Chinese population (pOR=0.002).ConclusionsOur case–control study failed to validate the significant association ofNKAPLrs1635,TSPAN18rs11038167, andMPC2rs10489202 polymorphisms with SZ susceptibility in the southern Zhuang or Han Chinese population. However, meta-analysis showed a significant association betweenMPC2variant rs10489202 and SZ susceptibility in Han Chinese.

Polymorphisms in the dopamine D3 receptor gene and improvement in positive symptoms of schizophrenia

2003 ◽  
Vol 60 (1) ◽  
pp. 90-91
Author(s):  
S. Staddon ◽  
M.J. Arranz ◽  
P. Buckland ◽  
S. Osborne ◽  
I. Mata ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Positive Symptoms ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Dopamine D3
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