Long-Term Results with a Slow-Release Gonadotrophin-Releasing Hormone Agonist in Central Precocious Puberty

1991 ◽  
Vol 80 (s372) ◽  
pp. 39-45 ◽  
Author(s):  
W. OOSTDUK ◽  
S. L. S. DROP ◽  
R. J. H. ODINK ◽  
R. HÜMMELINK ◽  
C. J. PARTSCH ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Slow Release ◽  
Central Precocious Puberty ◽  
Long Term Results ◽  
Releasing Hormone ◽  
Gonadotrophin Releasing Hormone

Long-Term Results of GnRH Analogue (Buserelin) Treatment in Girls with Central Precocious Puberty

1985 ◽  
Vol 74 (6) ◽  
pp. 945-949 ◽  
Author(s):  
R. BRAUNER ◽  
E. THIBAUD ◽  
P. BISCHOF ◽  
PC. SIZONENKO ◽  
R. RAPPAPORT
Keyword(s):  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Long Term Results ◽  
Gnrh Analogue ◽  
Buserelin Treatment

Use of a new drug delivery formulation of the gonadotrophin-releasing hormone analogue Deslorelin for reversible long-term contraception in male dogs

2003 ◽  
Vol 15 (6) ◽  
pp. 317 ◽  
Author(s):  
A. Junaidi ◽  
P. E. Williamson ◽  
J. M. Cummins ◽  
G. B. Martin ◽  
M. A. Blackberry ◽  
...  
Keyword(s):  
Slow Release ◽  
Semen Quality ◽  
Animal Health ◽  
Plasma Concentrations ◽  
Testicular Volume ◽  
Releasing Hormone ◽  
Detectable Range ◽  
Effect Of Treatment ◽  
Gonadotrophin Releasing Hormone

In the present study, we tested the effect of treatment with a slow-release implant containing the gonadotrophin-releasing hormone agonist DeslorelinTM (Peptech Animal Health Australia, North Ryde, NSW, Australia) on pituitary and testicular function in mature male dogs. Four dogs were treated with Deslorelin (6-mg implant) and four were used as controls (blank implant). In control dogs, there were no significant changes over the 12 months of the study in plasma concentrations of luteinising hormone (LH) or testosterone, or in testicular volume, semen output or semen quality. In Deslorelin-treated dogs, plasma concentrations of LH and testosterone were undetectable after 21 and 27 days, testicular volume fell to 35% of pretreatment values after 14 weeks and no ejaculates could be obtained after 6 weeks. Concentrations returned to the detectable range for testosterone after 44 weeks and for LH after 51 weeks and both were within the normal range after 52 weeks. Semen characteristics had recovered completely by 60 weeks after implantation. At this time, the testes and prostate glands were similar histologically to those of control dogs. We conclude that a single slow-release implant containing 6 mg Deslorelin has potential as a long-term, reversible antifertility agent for male dogs.

scholarly journals Final height in central precocious puberty after long term treatment with a slow release GnRH agonist.

1996 ◽  
Vol 75 (4) ◽  
pp. 292-297 ◽  
Author(s):  
W Oostdijk ◽  
B Rikken ◽  
S Schreuder ◽  
B Otten ◽  
R Odink ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Gnrh Agonist ◽  
Slow Release ◽  
Final Height ◽  
Central Precocious Puberty ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Central Precocious Puberty – Management and Long-term Outcomes

2015 ◽  
Vol 11 (1) ◽  
pp. 45 ◽  
Author(s):  
Juliane Léger ◽  
◽  
◽  
Keyword(s):  
Precocious Puberty ◽  
Standard Treatment ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Long Term Outcomes ◽  
Releasing Hormone ◽  
Hypothalamic Lesions ◽  
Gonadotropic Axis

Central precocious puberty (CPP) results from premature re-activation of the gonadotropic axis. CPP is much more common in girls than in boys and is idiopathic in most cases. In boys, precocious puberty is more likely to be linked to hypothalamic lesions (≈40%). Recent studies have implicated the inactivation ofMKRN3gene in ‘idiopathic’ CPP. Gonadotropin-releasing hormone agonists are the standard treatment for progressive CPP.

Treatment of children with central precocious puberty by a slow-release gonadotropin-releasing hormone agonist

1990 ◽  
Vol 149 (5) ◽  
pp. 308-313 ◽  
Author(s):  
W. Oostdijk ◽  
R. Hümmelink ◽  
R. J. H. Odink ◽  
C. J. Partsch ◽  
S. L. S. Drop ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Slow Release ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Agonist
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