Role of natriuretic hormones in the diagnosis of patent ductus arteriosus in newborn infants

Background: Patent ductus arteriosus (PDA) is a common cause of morbidity and mortality among premature infants that affects more than 40% of them. PDA treatment includes medical and surgical treatment. Most drugs used to block PDA are cyclooxygenase inhibitors (ibuprofen and indomethacin). The role of paracetamol as an alternative therapy in PDA ligation has been considered in recent years due to the potential side effects of cyclooxygenase inhibitors.Methods: Patients in the first group were treated with intravenous paracetamol at a dose of 15 mg/kg every 6 hours for three days and the second group was treated with intravenous ibuprofen at a daily dose of 10 mg/kg daily and 5 mg/kg for the second and third days. At the end of the treatment period (day 3), they underwent echocardiography again. If the echocardiographic findings indicated no closure of the arterial duct, patients were treated with the aforementioned drug for another period and rechecked at the end of the third day, and at each stage required information was collected.Results: Arterial duct closure in paracetamol group was 96.7% and in ibuprofen group was 100%. The effects of both paracetamol and ibuprofen were similar in terms of renal parameters but in terms of effects on liver parameters. The effect of paracetamol on all liver parameters except aspartate transaminase (AST) was significant, but ibuprofen was able to affect only bilirubin among liver parameters and had no significant effect on both AST and alanine aminotransferase, parameters.Conclusions: Results showed that both paracetamol and ibuprofen are effective in treating of PDA and had similar impact.

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Role of Transcatheter patent ductus arteriosus closure in extremely low birth weight infants

Catheterization and Cardiovascular Interventions ◽

10.1002/ccd.27808 ◽

2018 ◽

Vol 93 (1) ◽

pp. 89-96 ◽

Cited By ~ 22

Author(s):

Shyam Sathanandam ◽

Kaitlin Balduf ◽

Sandeep Chilakala ◽

Kristen Washington ◽

Kimberly Allen ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Patent Ductus Arteriosus ◽

Ductus Arteriosus ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants ◽

Patent Ductus Arteriosus Closure ◽

Patent Ductus

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Cardiovascular instability after patent ductus arteriosus ligation in preterm infants: the role of hydrocortisone

Journal of Perinatology ◽

10.1038/jp.2011.166 ◽

2011 ◽

Vol 32 (9) ◽

pp. 685-689 ◽

Cited By ~ 6

Author(s):

M D Satpute ◽

P K Donohue ◽

L Vricella ◽

S W Aucott

Keyword(s):

Patent Ductus Arteriosus ◽

Preterm Infants ◽

Ductus Arteriosus ◽

Cardiovascular Instability ◽

Patent Ductus

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A High Ductal Flow Velocity Is Associated with Successful Pharmacological Closure of Patent Ductus Arteriosus in Infants 22–27 Weeks Gestational Age

Critical Care Research and Practice ◽

10.1155/2012/715265 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Karl Wilhelm Olsson ◽

Anders Jonzon ◽

Richard Sindelar

Keyword(s):

Patent Ductus Arteriosus ◽

Flow Velocity ◽

Gestational Age ◽

Pharmacological Treatment ◽

Ductus Arteriosus ◽

Newborn Infants ◽

Cyclooxygenase Inhibitors ◽

Antenatal Steroids ◽

Ductal Closure ◽

Patent Ductus

Objective. To identify factors affecting closure of patent ductus arteriosus (PDA) in newborn infants born at 22–27 weeks gestational age (GA) during pharmacological treatment with cyclooxygenase inhibitors.Method. Infants born at 22–27 weeks of GA between January 2006 and December 2009 who had been treated pharmacologically for PDA were identified retrospectively. Medical records were assessed for clinical, ventilatory, and outcome parameters. Echocardiographic examinations during treatment were reviewed.Results. Fifty-six infants were included in the study. Overall success rate of ductal closure with pharmacological treatment was 52%. Infants whose PDA was successfully closed had a higher GA (25+4weeks versus24+3weeks;P=0.047),and a higher pretreatment left to right maximal ductal flow velocity (1.6 m/s versus 1.1 m/s;P=0.023). Correcting for GA, preeclampsia, antenatal steroids, and age at start of treatment, a higher maximal ductal flow velocity was still associated with successful ductal closure (OR 3.04;P=0.049).Conclusion. Maximal ductal flow velocity was independently associated with success of PDA treatment.

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THE ROLE OF HIGH SENSITIVITY TROPONIN T IN HEMODYNAMICALLY SIGNIFICANT PATENT DUCTUS ARTERIOSUS IN PREMATURE INFANTS

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(16)30955-x ◽

2016 ◽

Vol 67 (13) ◽

pp. 954

Author(s):

Priyanka Asrani ◽

Ashraf Aly ◽

Amyn Jiwani ◽

Sunil Jain

Keyword(s):

Patent Ductus Arteriosus ◽

Premature Infants ◽

Troponin T ◽

Ductus Arteriosus ◽

High Sensitivity ◽

High Sensitivity Troponin ◽

High Sensitivity Troponin T ◽

Patent Ductus

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Unmasking of patent ductus arteriosus on cardiopulmonary bypass: Role of intraoperative trans-esophageal echocardiography in a patient with severe pulmonary hypertension due to pulmonary vein stenosis and cor triatriatum

Annals of Cardiac Anaesthesia ◽

10.4103/0971-9784.81573 ◽

2011 ◽

Vol 14 (2) ◽

pp. 152 ◽

Cited By ~ 1

Author(s):

Suman Kandachar ◽

Murali Chakravarthy ◽

Jayaprakash Krishnamoorthy ◽

Sharadaprasad Suryaprakash ◽

Geetha Muniappa ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Cardiopulmonary Bypass ◽

Patent Ductus Arteriosus ◽

Pulmonary Vein ◽

Ductus Arteriosus ◽

Pulmonary Vein Stenosis ◽

Severe Pulmonary Hypertension ◽

Vein Stenosis ◽

Patent Ductus

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The Patent Ductus Arteriosus in Adults with Special Focus on Role of CT

Diagnostics ◽

10.3390/diagnostics11122394 ◽

2021 ◽

Vol 11 (12) ◽

pp. 2394

Author(s):

Soo Jeong Lee ◽

Seung Min Yoo ◽

Min Ji Son ◽

Charles S. White

Keyword(s):

Patent Ductus Arteriosus ◽

Imaging Modality ◽

Ductus Arteriosus ◽

High Rate ◽

Special Focus ◽

Clinical Perspective ◽

Occluder Device ◽

Missed Diagnosis ◽

Patent Ductus

The primary imaging modality for the diagnosis of patent ductus arteriosus (PDA) is echocardiography. However, CT may be the technique on which an incidental PDA is first recognized because of the increasing number of chest CT scans performed for a variety of causes. Identification of PDA on CT may lead to earlier closure using a PDA occluder device. Immediate identification of incidental PDA is important, but a high rate of missed diagnosis of PDA has been reported due to its small size and anatomic location. In addition, echocardiography may overlook the presence of even a large PDA due to decrease in the amount of shunting through the PDA caused by high pulmonary artery pressures. This review provides the basic CT anatomy and clinical perspective of PDA, and discusses the role of CT in the evaluation of PDA as well as methods to avoid overlooking a small PDA on CT.

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