WATER SOLUBLE VEGETABLE OLIGOPEPTIDES: COMPARATIVE STUDY ON ALCOHOL METABOLISM AND PLASMA AMINO ACID CONCENTRATIONS IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

1998 ◽  
Vol 22 (3) ◽  
pp. 227-244 ◽  
Author(s):  
M. YAMAGUCHI ◽  
F. NISHIKORI ◽  
M. YOSHIDA ◽  
M. ITO ◽  
Y. FURUKAWA
Keyword(s):  
Amino Acid ◽  
Comparative Study ◽  
Spontaneously Hypertensive Rats ◽  
Water Soluble ◽  
Plasma Amino Acid ◽  
Alcohol Metabolism ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Amino Acid Concentrations

The Site of Involvement of Hypertension within the Cochlea:A Comparative Study of Normotensive and Spontaneously Hypertensive Rats

1984 ◽  
Vol 97 (3-4) ◽  
pp. 257-265 ◽  
Author(s):  
M. Tachibana ◽  
I. Yamamichi ◽  
S. Nakae ◽  
Y. Hirasugi ◽  
M. Machino And ◽  
...  
Keyword(s):  
Comparative Study ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Excitatory and inhibitory amino acid changes in ischemic brain regions in spontaneously hypertensive rats

1991 ◽  
Vol 16 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Hiroaki Ooboshi ◽  
Hiroshi Yao ◽  
Takashi Matsumoto ◽  
Makoto Hirano ◽  
Hideyuki Uchimura ◽  
...  
Keyword(s):  
Amino Acid ◽  
Spontaneously Hypertensive Rats ◽  
Brain Regions ◽  
Hypertensive Rats ◽  
Ischemic Brain ◽  
Spontaneously Hypertensive

scholarly journals Dissecting the Role of Folr1 and Folh1 Genes in the Pathogenesis of Metabolic Syndrome in Spontaneously Hypertensive Rats

2018 ◽  
pp. 657-662 ◽  
Author(s):  
J. ŠILHAVÝ ◽  
J. KRIJT ◽  
J. SOKOLOVÁ ◽  
V. ZÍDEK ◽  
P. MLEJNEK ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Amino Acid ◽  
Spontaneously Hypertensive Rats ◽  
Brown Norway ◽  
Sulfur Amino Acid ◽  
Hypertensive Rats ◽  
Metabolic Disturbances ◽  
Spontaneously Hypertensive ◽  
Glucose And Lipid Metabolism ◽  
Amino Acid Levels

Increased levels of plasma cysteine predispose to obesity and metabolic disturbances. Our recent genetic analyses in spontaneously hypertensive rats (SHR) revealed mutated Folr1 (folate receptor 1) on chromosome 1 as a quantitative trait gene associated with reduced folate levels, hypercysteinemia and metabolic disturbances. The Folr1 gene is closely linked to the Folh1 (folate hydrolase 1) gene which codes for an enzyme involved in the hydrolysis of dietary polyglutamyl folates in the intestine. In the current study, we obtained evidence that Folh1 mRNA of the BN (Brown Norway) origin is weakly but significantly expressed in the small intestine. Next we analyzed the effects of the Folh1 alleles on folate and sulfur amino acid levels and consecutively on glucose and lipid metabolism using SHR-1 congenic sublines harboring either Folr1 BN and Folh1 SHR alleles or Folr1 SHR and Folh1 BN alleles. Both congenic sublines when compared to SHR controls, exhibited significantly reduced folate clearance and lower plasma cysteine and homocysteine levels which was associated with significantly decreased serum glucose and insulin concentrations and reduced adiposity. These results strongly suggest that, in addition to Folr1, the Folh1 gene also plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat.

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