scholarly journals Preliminary computational modeling of nitric oxide synthase 3 interactions with caveolin-1: influence of exon 7 Glu298Asp polymorphism

2008 ◽  
Vol 40 (1) ◽  
pp. 47-54 ◽  
Author(s):  
M. S. Joshi ◽  
J. A. Bauer
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Computational Modeling ◽  
Caveolin 1 ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase ◽  
Glu298asp Polymorphism

The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case–control studies

2006 ◽  
Vol 121 (2) ◽  
pp. 169-178 ◽  
Author(s):  
Klaus Berger ◽  
Florian Stögbauer ◽  
Monika Stoll ◽  
Juergen Wellmann ◽  
Andreas Huge ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ischemic Stroke ◽  
Nitric Oxide Synthase ◽  
Case Control ◽  
Case Control Studies ◽  
Independent Case ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase ◽  
Glu298asp Polymorphism

Nitric oxide synthase 3

2009 ◽  
Author(s):  
Thomas Michel
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

scholarly journals Nitric Oxide Synthase 3-Mediated Neurodegeneration After Intracerebral Gene Delivery

2007 ◽  
Vol 66 (4) ◽  
pp. 272-283 ◽  
Author(s):  
Suzanne M. de la Monte ◽  
Ami Jhaveri ◽  
Bradley A. Maron ◽  
Jack R. Wands
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Gene Delivery ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

scholarly journals Altered Angiogenesis in Caveolin-1 Gene–Deficient Mice Is Restored by Ablation of Endothelial Nitric Oxide Synthase

2012 ◽  
Vol 180 (4) ◽  
pp. 1702-1714 ◽  
Author(s):  
Christudas Morais ◽  
Quteba Ebrahem ◽  
Bela Anand-Apte ◽  
Marie-Odile Parat
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Caveolin 1 ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Deficient Mice

scholarly journals Stimulatory Roles of Nitric-oxide Synthase 3 and Guanylyl Cyclase in Platelet Activation

2005 ◽  
Vol 280 (45) ◽  
pp. 37430-37438 ◽  
Author(s):  
Jasna A. Marjanovic ◽  
Zhenyu Li ◽  
Aleksandra Stojanovic ◽  
Xiaoping Du
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Platelet Activation ◽  
Guanylyl Cyclase ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

Effects of lipoproteins from pre-eclamptic women on umbilical endothelial cell 6-oxo-prostaglandin F1α and endothelin 1 synthesis, and nitric oxide synthase 3 mRNA expression

1999 ◽  
Vol 97 (6) ◽  
pp. 697-706 ◽  
Author(s):  
A. BARDEN ◽  
L. J. BEILIN ◽  
K. BOTH ◽  
J. RITCHIE ◽  
P. LEEDMAN ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cell ◽  
Nitric Oxide Synthase ◽  
Pregnant Women ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Endothelin 1 ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

In order to evaluate whether lipid abnormalities may contribute to endothelial dysfunction in pre-eclampsia, the present study examined the in vitro effects of very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), isolated from women with pre-eclampsia and matched controls, on the endothelial synthesis of 6-oxo-prostaglandin F1α (6-oxo-PGF1α; a metabolite of prostacyclin) and endothelin 1, and on the expression of nitric oxide synthase 3 (NOS3) mRNA. VLDL, LDL and HDL cholesterol were isolated from 20 pre-eclamptic and 20 age- and gestation-matched normal pregnant women. The lipoproteins (50 μg/ml) and lipoprotein-free control plasma were incubated for 1, 3 and 6 h at 37 °C with a human umbilical endothelial cell line. The synthesis of 6-oxo-PGF1α and endothelin 1, and NOS3 mRNA expression, were measured at each time point. VLDL from pre-eclamptic women stimulated endothelial cell 6-oxo-PGF1α synthesis to a lesser extent than that from normal pregnant women (P< 0.05). LDL from women with pre-eclampsia also stimulated 6-oxo-PGF1α synthesis to a lesser extent than LDL from normal pregnant women, but the effect was less sustained. The effect of HDL from women with pre-eclampsia on 6-oxo-PGF1α synthesis was similar to that of HDL from normal pregnant women. The pre-incubation levels of lipid peroxides in VLDL and LDL were not different between the normal pregnant and pre-eclamptic women, and cannot account for the decrease in 6-oxo-PGF1α synthesis. VLDL, LDL and HDL from women with pre-eclampsia did not affect endothelial cell synthesis of endothelin 1 or expression of NOS3 mRNA differently from lipoproteins from normal pregnant women. This study suggests that VLDL, and to a lesser extent LDL, from women with pre-eclampsia could potentially contribute to the reduced systemic 6-oxo-PGF1α synthesis observed in the pre-eclamptic syndrome.

OVER-EXPRESSION OF NITRIC OXIDE SYNTHASE-3 (NOS-3) AND FREE-RADICAL INJURY CAUSE APOPTOSIS AND PHOSPHO-TAU ACCUMULATION IN NEURONAL CELLS

1999 ◽  
Vol 58 (5) ◽  
pp. 512 ◽  
Author(s):  
S. M. de Monte ◽  
N. Ganiu ◽  
T. Luong ◽  
S. Janssens ◽  
K. D. Bloch ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Nitric Oxide Synthase ◽  
Neuronal Cells ◽  
Over Expression ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

scholarly journals Angiotensin II causes nitric oxide synthase 3 uncoupling in the thick ascending limb

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Katherine Massey ◽  
Jagannath J. Saikumar ◽  
Mark D. Faber ◽  
Jerry J. Yee ◽  
Jeffrey L. Garvin
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthase ◽  
Thick Ascending Limb ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms

2006 ◽  
Vol 101 (1) ◽  
pp. 348-353 ◽  
Author(s):  
Rhonda D. Prisby ◽  
M. Keith Wilkerson ◽  
Elke M. Sokoya ◽  
Robert M. Bryan ◽  
Emily Wilson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Methyl Ester ◽  
Nitric Oxide Synthase ◽  
Cerebral Perfusion ◽  
Simulated Microgravity ◽  
Cerebral Arteries ◽  
Caveolin 1 ◽  
Fluid Shifts ◽  
Oxide Synthase

Cephalic elevations in arterial pressure associated with microgravity and prolonged bed rest alter cerebrovascular autoregulation in humans. Using the head-down tail-suspended (HDT) rat to chronically induce headward fluid shifts and elevate cerebral artery pressure, previous work has likewise shown cerebral perfusion to be diminished. The purpose of this study was to test the hypothesis that 2 wk of HDT reduces cerebral artery vasodilation. To test this hypothesis, dose-response relations for endothelium-dependent (2-methylthioadenosine triphosphate and bradykinin) and endothelium-independent (nitroprusside) vasodilation were determined in vitro in middle cerebral arteries (MCAs) from HDT and control rats. All in vitro measurements were done in the presence and absence of the nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (10−5 M) and cyclooxygenase inhibitor indomethacin (10−5 M). MCA caveolin-1 protein content was measured by immunoblot analysis. Endothelium-dependent vasodilation to 2-methylthioadenosine triphosphate and bradykinin were both lower in MCAs from HDT rats. These lower vasodilator responses were abolished with NG-nitro-l-arginine methyl ester but were unaffected by indomethacin. In addition, HDT was associated with lower levels of MCA caveolin-1 protein. Endothelium-independent vasodilation was not altered by HDT. These results indicate that chronic cephalic fluid shifts diminish endothelium-dependent vasodilation through alterations in the endothelial nitric oxide synthase signaling mechanism. Such decrements in endothelium-dependent vasodilation of cerebral arteries could contribute to the elevations in cerebral vascular resistance and reductions in cerebral perfusion that occur after conditions of simulated microgravity in HDT rats.

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