HEMATOLOGY OF THE NORMAL MONKEY*

2006 ◽  
Vol 85 (3) ◽  
pp. 803-810 ◽  
Author(s):  
George M. Krise
Keyword(s):  
Normal Monkey

Intracranial pressure in the normal monkey while awake and asleep

1979 ◽  
Vol 51 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Gündüz Gücer ◽  
Lawrence J. Viernstein
Keyword(s):  
Blood Pressure ◽  
Intracranial Pressure ◽  
Systemic Blood Pressure ◽  
Macaque Monkey ◽  
Short Term ◽  
Content Type ◽  
Plateau Waves ◽  
Normal Monkey ◽  
The Mean ◽  
Cervical Ganglia

✓ Intracranial pressure (ICP) was recorded continuously by telemetry in seven normal monkeys trained to eat, sleep, and live in a primate chair. Electroencephalography, electromyography, and blood pressure were also measured by conventional means. During wakefulness and all stages of sleep except desynchronized sleep, the ICP record showed small short-term variations in pressure. However, during desynchronized sleep, the mean ICP rose on the average to 170 ± 6 mm H2O above the ICP levels in the other states of sleep, and the pulsation pressure variation increased by a factor of three. The episodes occurred 10 ± 2 times during the night and lasted for 6.8 ± 1.4 minutes, during which the average systemic blood pressure decreased by 19 ± 1.6 mm Hg. These ICP waves occurring during desynchronized sleep resemble the plateau waves described by Lundberg, but are of smaller magnitude and they appear to be a normal characteristic of sleep in the macaque monkey. Bilateral sympathectomy of the superior cervical ganglia in four of the monkeys did not alter significantly the duration, amplitude, or frequency of occurrence of the ICP waves during desynchronized sleep.

scholarly journals STUDIES ON EXPERIMENTAL PNEUMONIA

1920 ◽  
Vol 32 (4) ◽  
pp. 401-426 ◽  
Author(s):  
Francis G. Blake ◽  
Russell L. Cecil
Keyword(s):  
Respiratory Tract ◽  
Interstitial Pneumonia ◽  
Interstitial Tissue ◽  
Upper Respiratory Tract ◽  
Pulmonary Tissue ◽  
Streptococcus Pneumonia ◽  
Normal Monkey ◽  
Considerable Resistance ◽  
Nose And Throat ◽  
Intratracheal Injection

1. Pneumonia has been consistently produced in normal monkeys by intratracheal injection of Streptococcus hæmolyticus. 2. The pneumonia produced has been shown to be comparable with hemolytic streptococcus pneumonia in man with respect to its clinical features, complications, and pathology. 3. Two pathologic types of the disease have occurred, interstitial pneumonia and confluent lobular pneumonia. Both types have been found in the same animal. 4. The type of pneumonia has appeared to be dependent upon the amount of streptococcus culture injected, interstitial pneumonia following the injection of small amounts and being an expression of considerable resistance, confluent lobular pneumonia following the injection of large amounts and being an expression of comparative lack of resistance. 5. Study of the distribution of streptococci in the lungs and of the character of the lesions in early stages of the disease has shown that streptococci may primarily invade the pulmonary tissue by penetration of the walls of the larger bronchial branches and that they are distributed from the points of invasion by way of the peribronchial, perivascular, and septal interstitial tissue and lymphatics. Infection of the alveoli is likewise primarily an interstitial invasion of the alveolar walls by streptococci. 6. In one experiment it was found that preliminary injury to the respiratory tract by gassing with chlorine and that lowering of resistance by a preceding intraperitoneal injection of Bacillus influenza without local injury to the respiratory tract greatly facilitated invasion of the lungs by Streptococcus hæmolyticus. 7. A normal monkey inoculated in the nose and throat with Streptococcus hæmolyticus failed to develop pneumonia and showed no evidence of infection of the upper respiratory tract.

Radioimmunoassay of inhibin in the serum of male monkeys

1989 ◽  
Vol 122 (2) ◽  
pp. 477-483 ◽  
Author(s):  
U. Fingscheidt ◽  
G. F. Weinbauer ◽  
D. M. Robertson ◽  
D. M. de Kretser ◽  
E. Nieschlag
Keyword(s):  
Coefficient Of Variation ◽  
Macaca Fascicularis ◽  
Serum Samples ◽  
Response Curves ◽  
Serum Pool ◽  
Normal Monkey ◽  
Interassay Coefficient ◽  
Gonadotrophin Releasing Hormone ◽  
Radioimmunoassay Method ◽  
Marked Suppression

ABSTRACT A heterologous inhibin radioimmunoassay method to measure inhibin in serum of male cynomolgus (Macaca fascicularis) and rhesus (Macaca mulatta) monkeys has been validated using a specific antibody against bovine 31 kDa inhibin and 125I-labelled 31 kDa inhibin as tracer. A serum pool from male monkeys was used as standard. Serial dilutions of normal monkey serum showed parallel logit–log dose–response curves to purified porcine and bovine inhibin as well as to a female human serum pool. The intra-assay coefficient of variation was 4·2% (n=10) and the interassay coefficient of variation 5·1% (n=10). No loss of inhibin immunoactivity was noted after storage at 23 °C for 5 days or repeated thawing and freezing of the serum samples. Serum from castrated monkeys showed undetectable levels of inhibin. Treatment with a gonadotrophin-releasing hormone agonist for 15 weeks led to a marked suppression of peripheral serum inhibin to concentrations similar to those after hypophysectomy or pituitary stalk section. Journal of Endocrinology (1989) 122, 477–483

scholarly journals Lamina Cribrosa Microarchitecture in Normal Monkey Eyes Part 1: Methods and Initial Results

2015 ◽  
Vol 56 (3) ◽  
pp. 1618-1637 ◽  
Author(s):  
H. Lockwood ◽  
J. Reynaud ◽  
S. Gardiner ◽  
J. Grimm ◽  
V. Libertiaux ◽  
...  
Keyword(s):  
Lamina Cribrosa ◽  
Normal Monkey ◽  
Initial Results

Total Luminous Flux: A Possible Response Determinant for the Normal Monkey

Science ◽  
1967 ◽  
Vol 158 (3802) ◽  
pp. 806-809 ◽  
Author(s):  
P. Schilder ◽  
P. Pasik ◽  
T. Pasik
Keyword(s):  
Luminous Flux ◽  
Normal Monkey

scholarly journals An intracellular simian malarial parasite (Plasmodium knowlesi) induces stage-dependent alterations in membrane phospholipid organization of its host erythrocyte

1987 ◽  
Vol 246 (1) ◽  
pp. 103-108 ◽  
Author(s):  
P Joshi ◽  
G P Dutta ◽  
C M Gupta
Keyword(s):  
Developmental Stages ◽  
Plasmodium Knowlesi ◽  
Membrane Phospholipid ◽  
Malarial Parasite ◽  
Merocyanine 540 ◽  
Parasite Plasmodium ◽  
Normal Monkey ◽  
Infected Cells ◽  
Membrane Isolation ◽  
Different Sources

The membrane phospholipid organization in monkey erythrocytes harbouring different developmental stages of the simian malarial parasite Plasmodium knowlesi was studied using phospholipase A2 from two different sources and Merocyanine 540 as the external-membrane probes. Experiments were done to confirm that the phospholipases did not penetrate into the infected cells or hydrolyse phospholipids during membrane isolation. The parasite-free erythrocyte membrane was isolated by differential centrifugation or by using the cationic beads Affi-Gel 731. The purity of the membranes was established by optical and electron microscopy, and by assaying the parasite-specific enzyme glutamate dehydrogenase. About 10% of the phosphatidylethanolamine and none of phosphatidylserine were hydrolysed by the phospholipases in intact normal monkey erythrocytes. However, accessibility of these aminophospholipids to the enzymes was significantly enhanced in the infected cells under identical conditions. The degree of this enhancement depended on the developmental stage of the intracellular parasite, but not on the parasitaemia levels in the infected monkeys, and increased with the parasite growth inside the cells. Analogously, Merocyanine 540 was found to label the trophozoite- or schizont-infected erythrocytes, but not the ring-infected or normal cells. These results demonstrate that the intracellular malarial parasite produces stage-dependent alterations in the membrane phospholipid organization of its host erythrocyte.

scholarly journals THE RELATION OF MOSQUITOES AND FLIES TO THE EPIDEMIOLOGY OF ACUTE POLIOMYELITIS

1917 ◽  
Vol 26 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Hideyo Noguchi ◽  
Rokusaburo Kudo
Keyword(s):  
Larval Stage ◽  
Culex Pipiens ◽  
Horse Serum ◽  
Intracerebral Injection ◽  
Monkey Brain ◽  
Large Numbers ◽  
Normal Monkey ◽  
The Common ◽  
Intrathecal Space ◽  
Acute Poliomyelitis

1. Culex pipiens raised from the larval stage in water experimentally contaminated with an abundance of poliomyelitic virus were found to be incapable of causing the infection when allowed in large numbers to bite normal Macacus monkeys. 2. Culex pipiens which were fed on infected poloimyelitic monkeys during different stages of the disease were found to be incapable of transmitting the infection when allowed in large numbers to bite normal Macacus monkeys. A previous disturbance of the meninges by an injection of horse serum into the intrathecal space did not alter the result, which was negative. 3. The offspring of the mosquitoes which were either reared in the infected tanks or fed on infected monkeys were found to be entirely harmless when allowed to feed in large numbers on a normal monkey. There was no hereditary transmission of the virus from one generation to another. 4. No trace of the virus of poliomyelitis was demonstrable in the filtrate of an emulsion of adult flies and pupae of the common housefly and bluebottle fly which were reared in the laboratory on slices, emulsion, or filtrate of monkey brain containing the poliomyelitic virus. The intracerebral injection of the filtrate produced no poliomyelitic infection in the normal monkey.

Spontaneous Rhythmic Synchronous Activity in Epileptic Human and Normal Monkey Temporal Lobe

Epilepsia ◽  
1986 ◽  
Vol 27 (5) ◽  
pp. 523-533 ◽  
Author(s):  
Philip A. Schwartzkroin ◽  
Michael M. Haglund
Keyword(s):  
Temporal Lobe ◽  
Synchronous Activity ◽  
Normal Monkey
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