Caffeic Acid and Ferulic Acid Inhibit UVA-Induced Matrix Metalloproteinase-1 through Regulation of Antioxidant Defense System in Keratinocyte HaCaT Cells

2012 ◽  
Vol 88 (4) ◽  
pp. 961-968 ◽  
Author(s):  
Thanyawan Pluemsamran ◽  
Tasanee Onkoksoong ◽  
Uraiwan Panich
Keyword(s):  
Matrix Metalloproteinase ◽  
Ferulic Acid ◽  
Caffeic Acid ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Hacat Cells ◽  
Defense System ◽  
Matrix Metalloproteinase 1

scholarly journals Erratum to: Ferulic acid chronic treatment exerts antidepressant-like effect: role of antioxidant defense system

2015 ◽  
Vol 30 (6) ◽  
pp. 1465-1465 ◽  
Author(s):  
Juliana Lenzi ◽  
Andre Felipe Rodrigues ◽  
Adriana de Sousa Rós ◽  
Amanda Blanski de Castro ◽  
Daniela Delwing de Lima ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Chronic Treatment ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System

Ferulic acid chronic treatment exerts antidepressant-like effect: role of antioxidant defense system

2015 ◽  
Vol 30 (6) ◽  
pp. 1453-1463 ◽  
Author(s):  
Juliana Lenzi ◽  
Andre Felipe Rodrigues ◽  
Adriana de Sousa Rós ◽  
Bianca Blanski de Castro ◽  
Daniela Delwing de Lima ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Chronic Treatment ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System

Effect of Caffeic Acid Dietary Supplementation on the Antioxidant Defense System in Rat: Anin VivoStudy

1997 ◽  
Vol 342 (1) ◽  
pp. 157-160 ◽  
Author(s):  
Mirella Nardini ◽  
Fausta Natella ◽  
Vincenzo Gentili ◽  
Maurizio Di Felice ◽  
Cristina Scaccini
Keyword(s):  
Caffeic Acid ◽  
Antioxidant Defense ◽  
Dietary Supplementation ◽  
Antioxidant Defense System ◽  
Defense System

scholarly journals Protective effect of honokiol against LPS-induced lung injury via attenuation of matrix metalloproteinase-9 and oxidative stress

2016 ◽  
Vol 68 (4) ◽  
pp. 877-881 ◽  
Author(s):  
Hong-Bo Li ◽  
Lin Wang ◽  
Zheng-Tao Gu ◽  
Xuan He ◽  
Lei Su
Keyword(s):  
Oxidative Stress ◽  
Lung Injury ◽  
Matrix Metalloproteinase ◽  
Protective Effect ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Matrix Metalloproteinase 9 ◽  
Defense System ◽  
Endogenous Antioxidant ◽  
Metalloproteinase 9

Despite high morbidity and mortality, no effective options are available for the treatment of acute lung injury (ALI). Therefore, the present study investigated the protective effect of honokiol (HK) on ALI via determination of its effect on several key biomarkers. The results of the study showed that HK significantly inhibited the infiltration of neutrophils and protein leakage induced by lipopolysaccharide (LPS) (p<0.05). The pretreatment with HK considerably boosted the endogenous antioxidant defense system to counteract the oxidative stress in LPS-induced ALI by elevating the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH). Moreover, the activity of toxic mediators, such as myeloperoxidase (MPO), and lipid peroxidation were significantly inhibited upon treatment with HK. In order to examine the mechanism of action of HK, its effect was quantified using matrix metalloproteinase-9 (MMP-9) activity in bronchoalveolar lavage fluid (BALF) by gelatin zymography. Pretreatment with HK considerably suppressed the activation of MMP-9 in a concentration-dependent manner. These findings suggest that HK protects from lung injury via inhibition of MMP-9, and by enhancing the activity of the endogenous antioxidant defense system.

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