IS REDUCED URINARY CALCIUM LOSS IN LONG-TERM PARENTERAL NUTRITION PATIENTS AN ADAPTIVE MECHANISM TO LIMIT BONE LOSS?

2009 ◽  
Vol 47 (6) ◽  
pp. 190-192
Keyword(s):  
Bone Loss ◽  
Parenteral Nutrition ◽  
Urinary Calcium ◽  
Adaptive Mechanism ◽  
Calcium Loss

scholarly journals Urinary calcium excretion in short bowel syndrome patients receiving cyclic parenteral nutrition: Case report

2012 ◽  
Vol 05 (03) ◽  
pp. 103-105
Author(s):  
Fernanda Rodella ◽  
Júlio Sérgio Marchini ◽  
Durval Ribas Filho ◽  
Gilberto João Padovan ◽  
Andressa Feijó da Silva Santos ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Short Bowel Syndrome ◽  
Metabolic Bone Disease ◽  
Case Reports ◽  
Urinary Calcium ◽  
Calcium Excretion ◽  
Short Bowel ◽  
Metabolic Bone ◽  
Calcium Loss

ABSTRACTTotal parenteral nutrition is essential for the survival of short bowel syndrome patients. However, in the long term it is associated with complications such as metabolic bone disease. This complication has been attributed, among other causes, to an increased urinary calcium loss, which might be related to the amount of aminoacids, glucose and calcium present in the parenteral nutrition solution. Two case reports are here presented showing normal calciuria in short bowel syndrome adults, receiving parenteral nutrition for up to 5 years after extensive bowel resection.

Progressive bone loss during long-term home total parenteral nutrition

1990 ◽  
Vol 14 (2) ◽  
pp. 139-142 ◽  
Author(s):  
J Foldes ◽  
B Rimon ◽  
M Muggia-Sullam ◽  
Z Gimmon ◽  
I Leichter ◽  
...  
Keyword(s):  
Bone Loss ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition

scholarly journals A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Typhaine Louazon ◽  
Pierre Poinsot ◽  
Lioara Restier ◽  
Abdelouahed Belmalih ◽  
Irène Loras-Duclaux ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Bone Microarchitecture ◽  
Imaging Techniques ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Case Control ◽  
Urinary Calcium ◽  
Biological Assessment ◽  
Cross Sectional

AbstractLong-term parenteral nutrition (PN) may induce bone complications. Tridimensional bone imaging techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) allow the assessment of both compartmental volumetric densities and microarchitecture. Our aim was to evaluate these parameters in children and teenagers receiving long-term PN. This cross-sectional, case–control study included children older than 9 years undergoing PN for at least 2 years. They were age-, gender- and puberty-matched with healthy controls (1:2). Evaluation included biological assessment of bone metabolism (serum calcium, phosphate, and albumin; urinary calcium and creatinine; 25-OH vitamin D, osteocalcin and PTH), dual X-ray absorptiometry (DXA) and HR-pQCT at the ultradistal tibia and radius. Results are presented as median [range]. Eleven patients (3 girls) with a median age of 16 [9–19] years were included. Bone parameters assessed by HR-pQCT at the ultradistal radius and tibia were similar in patients and controls. Parathyroid hormone (PTH) levels were higher (14 [7–115] vs 16 [12–27]) and osteocalcin levels were lower (44 [15–65] vs 65 [38–142]) in patients than in controls, although within the normal range. Conclusions: there were no differences for compartmental bone densities and microarchitecture in patients undergoing chronic PN. Further longitudinal studies are required to confirm these quite reassuring preliminary results.

scholarly journals Parenteral Nutrition and Oxidant Load in Neonates

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2631
Author(s):  
Kandeepan Karthigesu ◽  
Robert F. Bertolo ◽  
Robert J. Brown
Keyword(s):  
Parenteral Nutrition ◽  
Storage Temperature ◽  
Oral Feeding ◽  
Published Data ◽  
Short Term ◽  
Antioxidant Defences ◽  
Term Survival ◽  
Nutrient Sources ◽  
Short Term Survival

Neonates with preterm, gastrointestinal dysfunction and very low birth weights are often intolerant to oral feeding. In such infants, the provision of nutrients via parenteral nutrition (PN) becomes necessary for short-term survival, as well as long-term health. However, the elemental nutrients in PN can be a major source of oxidants due to interactions between nutrients, imbalances of anti- and pro-oxidants, and environmental conditions. Moreover, neonates fed PN are at greater risk of oxidative stress, not only from dietary sources, but also because of immature antioxidant defences. Various interventions can lower the oxidant load in PN, including the supplementation of PN with antioxidant vitamins, glutathione, additional arginine and additional cysteine; reduced levels of pro-oxidant nutrients such as iron; protection from light and oxygen; and proper storage temperature. This narrative review of published data provides insight to oxidant molecules generated in PN, nutrient sources of oxidants, and measures to minimize oxidant levels.

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