Expression of 12 cytokines in aqueous humour of uveal melanoma before and after combined Ruthenium-106 brachytherapy and transpupillary thermotherapy

AbstractIntraocular surgery is associated with increased ocular inflammation. If maintained for a prolonged period after surgery, this inflammation can cause various complications, including subconjunctival fibrosis and bleb scarring. This clinical trial was a prospective, randomised, single-blind, interventional study comparing the efficacy and safety of 0.1% bromfenac sodium ophthalmic solution and 0.02% fluorometholone ophthalmic suspension in the inhibition of multiple inflammatory cytokines in the aqueous humour of 26 patients with pseudophakic eyes who had undergone phacoemulsification and intraocular lens implantation. The patients were randomly assigned to one of the trial drugs, and aqueous humour samples were collected before and after drug administration. Platelet-derived growth factor-AA levels significantly decreased in both drug groups, but they were significantly higher in the fluorometholone group than in the bromfenac group (P = 0.034). Bromfenac also significantly decreased vascular endothelial growth factor level (P = 0.0077), as well as monocyte chemoattractant protein-1 level (P = 0.013), which was elevated for a prolonged period after phacoemulsification. These data suggest that bromfenac is useful to alleviate prolonged microenvironmental alterations in the aqueous humour of pseudophakic eyes.

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Cytokines in Aqueous Humour and Serum before and after Corneal Transplantation and during Rejection

Ophthalmic Research ◽

10.1159/000055607 ◽

2000 ◽

Vol 32 (4) ◽

pp. 157-164 ◽

Cited By ~ 13

Author(s):

B.E. van Gelderen ◽

A. Van der Lelij ◽

R. Peek ◽

L. Broersma ◽

W.F. Treffers ◽

...

Keyword(s):

Aqueous Humour ◽

Corneal Transplantation ◽

Before And After

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OCT changes in peri-tumour normal retina following ruthenium-106 and proton beam radiotherapy for uveal melanoma

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-314802 ◽

2020 ◽

pp. bjophthalmol-2019-314802

Author(s):

Rumana Hussain ◽

Florian Moritz Heussen ◽

Heinrich Heimann

Keyword(s):

Proton Beam ◽

Uveal Melanoma ◽

Choroidal Melanoma ◽

Retinal Layer ◽

Proton Beam Radiotherapy ◽

Retinal Layers ◽

Spectral Domain Oct ◽

Ruthenium 106 Brachytherapy ◽

Safety Margins ◽

Plaque Brachytherapy

IntroductionUveal melanoma is most commonly treated with radiotherapy, destroying the tumour cells with adequate safety margins and limiting collateral damage to surrounding structures to preserve maximal vision. We used optical coherence tomography (OCT) to study the effects of radiotherapy on the retina.MethodsPatients with posteriorly located choroidal melanoma treated with proton beam radiotherapy (PBR) and ruthenium-106 brachytherapy between January 2010 and June 2014 underwent spectral domain OCT.ResultsImages of 32 patients following ruthenium-106 brachytherapy and 44 patients following proton beam teletherapy were analysed. Following plaque brachytherapy, an early marked disruption of the outer retinal layers could be observed in 30 cases (94%) with retinal atrophy evident in 26 cases (81%). In contrast, the images from patients who underwent PBR showed subtle outer retinal layer change with 16 cases (36%) showing some inner-outer segment junction disruption by 6 months and 63% by 24 months with minimal atrophy. In cases with tumours <2 mm from the fovea, the visual loss was significantly less at 6 and 12 months in the proton beam group.ConclusionIn comparison to ruthenium-106 plaque brachytherapy, PBR leads to more subtle and slower changes in the outer retinal layers enabling retention of visual function for longer. The difference in dosing regime and dose distribution across the tumour is likely to be causative for this structural differential.

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Efficacy and complications of ruthenium-106 brachytherapy for uveal melanoma: a systematic review and meta-analysis

Journal of Contemporary Brachytherapy ◽

10.5114/jcb.2021.106191 ◽

2021 ◽

Vol 13 (3) ◽

pp. 358-364

Author(s):

Saeed Karimi ◽

Amir Arabi ◽

Zahra Siavashpour ◽

Toktam Shahraki ◽

Iman Ansari

Keyword(s):

Systematic Review ◽

Uveal Melanoma ◽

Meta Analysis ◽

Ruthenium 106 Brachytherapy

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The Role of Combined Therapy in the Treatment of Retinopathy and Optic Neuropathy Due to Radiotherapy in the Uveal Melanoma

Asian Journal of Oncology ◽

10.1055/s-0040-1701391 ◽

2020 ◽

Vol 6 (01) ◽

pp. 01-02

Author(s):

Yasemin Benderli Cihan

Keyword(s):

Uveal Melanoma ◽

Optic Neuropathy ◽

Combined Therapy ◽

Tumor Resection ◽

Transpupillary Thermotherapy ◽

Particle Radiation ◽

Radiation Retinopathy ◽

Low Incidence ◽

Plaque Brachytherapy

Abstract Introduction Uveal melanoma has a relatively low incidence. Transpupillary thermotherapy (TTT), hypofractioned stereotactic radiotherapy (RT), stereotactic radiosurgery, plaque brachytherapy, charged particle radiation therapy, local tumor resection, enucleation, and exantation are applied in the treatment. Methods The importance given to radiotherapy has increased to get more satisfactory results while treating the patient. However, it is the treatment of radiation retinopathy and optic neuropathy from complications. Results Radiation retinopathy and optic neuropathy are the most important complications related to radiotherapy in the treatment of uveal melanoma. In recent years, many studies have been performed on the treatment of radiation retinopathy and optic neuropathy. Conclusion The consecutive use of triamcinolone in combination with anti-VEGF supports that it may be a future therapeutic agent in the treatment of complications.

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