The correlation between central corneal thickness and endothelial cells in healthy patients and in patients with cataract or primary open angle glaucoma

2012 ◽  
Vol 90 ◽  
pp. 0-0
Author(s):  
N JURKUTE ◽  
M PAJAUJIS ◽  
S GALGAUSKAS ◽  
D KRASAUSKAITE ◽  
R ASOKLIS
Keyword(s):  
Endothelial Cells ◽  
Central Corneal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Open Angle

Clinical Profile of Myopic Patients as a Risk Factor for Primary Open Angle Glaucoma - A Prospective Observational Study in Gorakhpur, Uttar Pradesh

2021 ◽  
Vol 8 (33) ◽  
pp. 3084-3089
Author(s):  
Ram Kumar Jaiswal ◽  
Ramyash Singh Yadav ◽  
Mridula Ranjan ◽  
Dipti Wahi ◽  
Chiranji Rai
Keyword(s):  
Risk Factor ◽  
Intraocular Pressure ◽  
Observational Study ◽  
High Myopia ◽  
Central Corneal Thickness ◽  
Prospective Observational Study ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Open Angle

BACKGROUND Myopia is a complex trait including both genetic and environmental factors as well as gene-environment interactions. It has been recognized as a risk factor for development of glaucoma. Both Myopia and raised IOP are known to increase mechanical stress at optic nerve head leading to glaucomatous nerve damage. This study intends to evaluate the clinical profile of myopic subjects and its correlation with Primary open angle glaucoma (POAG). METHODS A prospective observational study done from November 2019 to December 2020 after taking proper informed consent and ethical clearance. 164 eyes of 96 patients studied were divided into three groups, Group 1: low myopia (< -3.00D), Group 2: moderate myopia (-3.00 D to -5.75 D), Group 3: high myopia (≥ -6.00 D). A complete ocular examination was performed. Intraocular pressure was measured using Goldmann applanation tonometer. Visual field analysis using Humphrey automated perimetry was done in patients with suspected primary open angle glaucoma (POAG). Angle parameters and central corneal thickness (CCT) were measured using anterior segment optical coherence tomography (AS-OCT). RESULTS 164 eyes of 96 Myopic subjects were studied with no dropout during study period. Mean age was 46.05 yr. (range: 25-75 yr.). The refraction ranged from -0.50 DS to -17.00 DS. There was no statistically significant difference between Intraocular pressure (IOP), Central corneal thickness (CCT), corrected IOP and Nasal and Temporal Trabecular-iris Angle (TIA) between male and female of same age group. Mean IOP and mean CCT were found to vary significantly with age and with higher degree of myopia. Corrected IOP, Nasal and Temporal TIA increase significantly with higher degree of myopia. Cup-disc ratio (CDR) was found to be significantly higher in patients with moderate to high degree of Myopia. CONCLUSIONS Myopia is an important risk factor for development of primary open angle glaucoma, with its incidence increasing in patients with moderate to high myopia. KEYWORDS Myopia, Primary Open Angle Glaucoma, Intraocular Pressure, Central Corneal Thickness, Trabecular Iris Angle

scholarly journals Adjusting Intraocular Pressure for Central Corneal Thickness Does Not Improve Prediction Models for Primary Open-Angle Glaucoma

Ophthalmology ◽  
2012 ◽  
Vol 119 (3) ◽  
pp. 437-442 ◽  
Author(s):  
James D. Brandt ◽  
Mae O. Gordon ◽  
Feng Gao ◽  
Julia A. Beiser ◽  
J. Phillip Miller ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Central Corneal Thickness ◽  
Prediction Models ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Open Angle

Topical Ocular Hypotensive Medication to Delay or Prevent the Onset of Primary Open-Angle Glaucoma

2020 ◽  
pp. 85-90
Author(s):  
Alan D. Penman ◽  
Kimberly W. Crowder ◽  
William M. Watkins
Keyword(s):  
Ocular Hypertension ◽  
Central Corneal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Field Pattern ◽  
Controlled Clinical Trial ◽  
Glaucomatous Optic Neuropathy ◽  
Hypertension Treatment ◽  
Open Angle

The Ocular Hypertension Treatment Study (OHTS) was a randomized, open, placebo-controlled, clinical trial to determine whether reducing intraocular pressure (IOP) in eyes with ocular hypertension (OHTN) reduced the risk of developing primary open-angle glaucoma (POAG). The study found that topical ocular hypotensive medication was effective in delaying or preventing the development of glaucomatous optic neuropathy in eyes with OHTN. However, the authors recommended stratifying risk in patients with OHTN using variables such as baseline age, vertical and horizontal cup-to-disc ratio, visual field pattern standard deviation, IOP, and, especially, central corneal thickness.

scholarly journals Does the Central Corneal Thickness (CCT) retain its predictive value as a risk factor in Primary Open Angle Glaucoma patients with Diabetes Mellitus?

2019 ◽  
Vol 3 (2) ◽  
pp. 32-41
Author(s):  
Anadi Khatri ◽  
Bal Kumar Khatri ◽  
Madhu Thapa ◽  
Muna Kharel ◽  
Ashma K.C. ◽  
...  
Keyword(s):  
Risk Factor ◽  
Predictive Value ◽  
Central Corneal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Diabetic Patients ◽  
Open Angle ◽  
Cross Sectional ◽  
Patients With Diabetes

Background: Central Corneal thickness (CCT) is thicker in diabetic patients. This may cause the CCT to lose predictive power as a risk factor for primary open angle glaucoma (POAG) in patients with diabetes. Objective: To evaluate if CCT of POAG patients with diabetes retains its predictive value as a risk factor. Methods: A cross sectional analysis of sequential group of patients with POAG with and without diabetes were evaluated HbA1C in diabetic patients and CCT in both groups was measured and the severity of POAG was evaluated using visual field changes and optic disc changes. The correlation was evaluated using confidence interval and liner regression estimator analysis. Results: Five hundred and eighty-seven patients with POAG were evaluated. The mean CCT for the group combined was 540±34.9 μm. Three hundred and thirty-seven patients had no history of diabetes and had mean CCT of 531.1±19.6 μm. Two hundred and fifty of them had diabetes with mean corneal thickness of 549±20.2 μm. CCT retained its predictive value as a risk factor for severity in POAG patient without diabetes (p<0.05). CCT however was a less sensitive for evaluating risk/severity in POAG patients with diabetes (p>0.05). Conclusions: CCT values may not retain its predictive value of severity of POAG in patients with diabetes. Hence, CCT alone may not be a reliable marker and mislead treating physicians.

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